Publikationen
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2023 2023
Ortiz C. , Klein S. , Reul WH. , Magdaleno F. , Groeschl S. , Dietrich P. , Schierwagen R. , Uschner FE. , Torres S. , Hieber C. , Meier C. , Kraus N. , Tyc O. , Brol M. , Zeuzem S. , Welsch C. , Poglitsch M. , Hellerbrand C. , Alfonso-Prieto M. , Mira F. , Keller UAD. , Tetzner A. , Moore A. , Walther T. , Trebicka J. :Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1 Cell Reports 42 2023 )ISSN: 2211-1247 10.1016/j.celrep.2023.112059
2022 2022
Düll M. , Karlen V. , Vetter M. , Dietrich P. , Kupfer J. , Neurath M. , Kremer A. :Chronic pruritus represents a major burden in non-cholestatic hepatobiliary disorders In: JOURNAL OF HEPATOLOGY , AMSTERDAM 2022 Seitz T. , John N. , Sommer J. , Dietrich P. , Thasler WE. , Hartmann A. , Evert K. , Lang SA. , Boßerhoff AK. , Hellerbrand C. :Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche International Journal of Molecular Sciences 23 2022 ), Art.Nr.: 11524 ISSN: 1422-0067 10.3390/ijms231911524 Simon D. , Tascilar K. , Fagni F. , Kleyer A. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Mößner J. , Taubmann J. , Mutlu MY. , Knitza J. , Kemenes S. , Liphardt AM. , Schönau V. , Bohr D. , Schuster L. , Minopoulou I. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. , Hartmann F. :Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study. The Lancet Rheumatology 4 2022 ), S. e614-e625 ISSN: 2665-9913 10.1016/S2665-9913(22)00191-6 Simon D. , Tascilar K. , Kleyer A. , Fagni F. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Kliem T. , Moessner J. , Liphardt AM. , Schoenau V. , Bohr D. , Schuster L. , Hartmann F. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. :Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort Arthritis and Rheumatology 2022 )ISSN: 2326-5191 10.1002/art.42035 Tascilar K. , Simon D. , Kleyer A. , Fagni F. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Kliem T. , Moessner J. , Liphardt AM. , Schönau V. , Bohr D. , Schuster L. , Hartmann F. , Taubmann J. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. :LONG-TERM HUMORAL RESPONSE TO SARS-COV-2 VACCINATION IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE In: ANNALS OF THE RHEUMATIC DISEASES , LONDON 2022 10.1136/annrheumdis-2022-eular.5079
2021 2021
Düll M. , Wolf K. , Vetter M. , Dietrich P. , Neurath M. , Kremer A. :Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus Frontiers in Medicine 8 2021 ), Art.Nr.: 641163 ISSN: 2296-858X 10.3389/fmed.2021.641163 Fritz V. , Malek L. , Gaza A. , Wormser L. , Appel M. , Kremer A. , Thasler WE. , Neurath M. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. , Siebler J. :Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma Cancers 13 2021 ), S. 1-14 ISSN: 2072-6694 10.3390/cancers13051183 Gaza A. , Fritz V. , Malek L. , Wormser L. , Treiber N. , Danner J. , Kremer AE. , Thasler WE. , Siebler J. , Meister G. , Neurath MF. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. :Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 Neoplasia 23 2021 ), S. 502-514 ISSN: 1522-8002 10.1016/j.neo.2021.04.001 Seitz T. , Hackl C. , Freese K. , Dietrich P. , Mahli A. , Thasler RM. , Thasler WE. , Lang SA. , Boßerhoff AK. , Hellerbrand C. :Xanthohumol, a prenylated chalcone derived from hops, inhibits growth and metastasis of melanoma cells Cancers 13 2021 ), S. 1-12 ISSN: 2072-6694 10.3390/cancers13030511 Vetter M. , Dietrich P. , Kremer A. :Therapy adaption by dose titration of obeticholic acid in a 57-year-old female patient with PBC and advanced liver fibrosis In: SWISS MEDICAL WEEKLY , MUTTENZ 2021 Weindl L. , Atreya I. , Dietrich P. , Neubeck S. , Neurath M. , Pavel ME. :Targeted inhibition of the WEE1 kinase as a novel therapeutic strategy in neuroendocrine neoplasms Endocrine-Related Cancer 28 2021 ), S. 605-620 ISSN: 1351-0088 10.1530/ERC-20-0500
2020 2020
Dietrich P. , Wormser L. , Fritz V. , Seitz T. , de Maria M. , Schambony A. , Kremer A. , Günther C. , Itzel T. , Thasler WE. , Teufel A. , Trebicka J. , Hartmann A. , Neurath M. , von Hörsten S. , Boßerhoff AK. , Hellerbrand C. :Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer Journal of Clinical Investigation 130 2020 ), S. 2509-2526 ISSN: 0021-9738 10.1172/JCI131919 Jefremow A. , Wiesmüller M. , Rouse RA. , Dietrich P. , Kremer A. , Waldner M. , Neurath M. , Siebler J. :Beyond the border: The use of lenvatinib in advanced hepatocellular carcinoma after different treatment lines: A retrospective analysis Journal of Physiology and Pharmacology 71 2020 ), S. 717-728 ISSN: 0867-5910 10.26402/jpp.2020.5.11 Jefremow A. , Wiesmüller M. , Rouse RA. , Dietrich P. , Kremer A. , Waldner M. , Neurath M. , Siebler J. :Efficiency and Toxicity of Lenvatinib in Advanced HCC in Later Treatment Lines In: ONCOLOGY RESEARCH AND TREATMENT , BASEL 2020 Koch A. , Ebert EV. , Seitz T. , Dietrich P. , Berneburg M. , Boßerhoff AK. , Hellerbrand C. :Characterization of glycolysis-related gene expression in malignant melanoma Pathology Research and Practice 216 2020 ), Art.Nr.: 152752 ISSN: 0344-0338 10.1016/j.prp.2019.152752 Linck-Paulus L. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. :Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma Cells 9 2020 )ISSN: 2073-4409 10.3390/cells9010114 Schierwagen R. , Dietrich P. , Klein S. , Uschner FE. , Ortiz C. , Tyc O. , Torres S. , Hellerbrand C. , Sauerbruch T. , Trebicka J. :β-Arrestin2 is increased in liver fibrosis in humans and rodents Proceedings of the National Academy of Sciences of the United States of America 117 2020 ), S. 27082-27084 ISSN: 0027-8424 10.1073/pnas.2014337117 Seitz T. , Freese K. , Dietrich P. , Thasler WE. , Boßerhoff AK. , Hellerbrand C. :Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma Scientific Reports 10 2020 ), Art.Nr.: 4546 ISSN: 2045-2322 10.1038/s41598-020-61510-4 Simon D. , Tascilar K. , Krönke G. , Kleyer A. , Zaiss M. , Heppt F. , Meder C. , Atreya R. , Klenske E. , Dietrich P. , Abdullah A. , Kliem T. , Corte G. , Morf H. , Leppkes M. , Kremer A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Meier C. , Hueber A. , Manger K. , Manger B. , Berking C. , Tenbusch M. , Überla K. , Sticherling M. , Neurath M. , Schett G. , Ramming A. :Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion Nature Communications 11 2020 ), Art.Nr.: 3774 ISSN: 2041-1723 10.1038/s41467-020-17703-6 Simon D. , Tascilar K. , Krönke G. , Kleyer A. , Zaiss M. , Heppt F. , Meder C. , Atreya R. , Klenske E. , Dietrich P. , Abdullah A. , Kliem T. , Corte G. , Morf H. , Leppkes M. , Kremer A. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Maier C. , Hueber A. , Manger K. , Manger B. , Berking C. , Tenbusch M. , Überla K. , Sticherling M. , Neurath M. , Schett G. :Patients Receiving Cytokine Inhibitors Have Low Prevalence of SARS-CoV-2 Infection In: ARTHRITIS & RHEUMATOLOGY , HOBOKEN 2020
2019 2019
Dietrich P. , Gaza A. , Wormser L. , Fritz V. , Hellerbrand C. , Boßerhoff AK. :Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Neoplasia 21 2019 ), S. 257-268 ISSN: 1522-8002 10.1016/j.neo.2018.11.011 Dietrich P. , Hellerbrand C. , Boßerhoff AK. :The delta subunit of rod-specific photoreceptor cgmp phosphodiesterase (Pde6d) contributes to hepatocellular carcinoma progression Cancers 11 2019 ), Art.Nr.: 398 ISSN: 2072-6694 10.3390/cancers11030398 Freese K. , Dietrich P. , Boßerhoff AK. , Hellerbrand C. :Variation of different histone deacetylases and the functional effects of HDAC inhibitors in hepatocellular carcinoma International Liver Congress (Vienna 10. April 2019 - 14. April 2019 )In: JOURNAL OF HEPATOLOGY , AMSTERDAM 2019 Freese K. , Seitz T. , Dietrich P. , Lee SM. , Thasler WE. , Boßerhoff AK. , Hellerbrand C. :Histone deacetylase expressions in hepatocellular carcinoma and functional effects of histone deacetylase inhibitors on liver cancer cells in vitro Cancers 11 2019 ), Art.Nr.: 1587 ISSN: 2072-6694 10.3390/cancers11101587 Goeppert B. , Truckenmueller F. , Ori A. , Fritz V. , Albrecht T. , Fraas A. , Scherer D. , Silos RG. , Sticht C. , Gretz N. , Mehrabi A. , Bewerunge-Hudler M. , Pusch S. , Bermejo JL. , Dietrich P. , Schirmacher P. , Renner M. , Roessler S. :Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p Scientific Reports 9 2019 )ISSN: 2045-2322 10.1038/s41598-019-40857-3 Mahli A. , Seitz T. , Beckroege T. , Freese K. , Thasler WE. , Benkert M. , Dietrich P. , Weiskirchen R. , Boßerhoff AK. , Hellerbrand C. :Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro Cells 8 2019 )ISSN: 2073-4409 10.3390/cells8050457 Stieglitz D. , Lamm S. , Braig S. , Feuerer L. , Kuphal S. , Dietrich P. , Arndt S. , Echtenacher B. , Hellerbrand C. , Karrer S. , Boßerhoff AK. :BMP6-induced modulation of the tumor micro-milieu Oncogene 38 2019 ), S. 609-621 ISSN: 0950-9232 10.1038/s41388-018-0475-x
2018 2018
Dietrich P. , Freese K. , Mahli A. , Thasler WE. , Hellerbrand C. , Boßerhoff AK. :Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option Oncotarget 9 2018 ), S. 3605-3618 ISSN: 1949-2553 10.18632/oncotarget.23188 Dietrich P. , Kuphal S. , Spruss T. , Hellerbrand C. , Boßerhoff AK. :MicroRNA-622 is a novel mediator of tumorigenicity in melanoma by targeting Kirsten rat sarcoma Pigment Cell & Melanoma Research 2018 )ISSN: 1755-1471 10.1111/pcmr.12698 Schmidt KM. , Dietrich P. , Hackl C. , Guenzle J. , Bronsert P. , Wagner C. , Fichtner-Feigl S. , Schlitt HJ. , Geissler EK. , Hellerbrand C. , Lang SA. :Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis Neoplasia 20 2018 ), S. 1198-1208 ISSN: 1522-8002 10.1016/j.neo.2018.10.001
2017 2017
Dietrich P. , Boßerhoff AK. :Melanoma sponge on pigmentation gene to reduce tumour-suppressive microRNAs Pigment Cell & Melanoma Research 2017 )ISSN: 1755-1471 10.1111/pcmr.12660 Dietrich P. , Koch A. , Fritz V. , Hartmann A. , Boßerhoff AK. , Hellerbrand C. :Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance Gut 2017 )ISSN: 0017-5749 10.1136/gutjnl-2017-315402 Dietrich P. , Kuphal S. , Spruss T. , Hellerbrand C. , Boßerhoff AK. :Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition Oncogene 2017 )ISSN: 0950-9232 10.1038/onc.2017.391 Mahli A. , Saugspier M. , Koch A. , Sommer J. , Dietrich P. , Lee S. , Thasler R. , Schulze-Luehrmann J. , Lührmann A. , Thasler WE. , Müller M. , Boßerhoff AK. , Hellerbrand C. :ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis Gut 2017 )ISSN: 0017-5749 10.1136/gutjnl-2016-312485
2015 2015
Delic S. , Thuy A. , Schulze M. , Proescholdt MA. , Dietrich P. , Boßerhoff AK. , Riemenschneider MJ. :Systematic Investigation of CMTM Family Genes Suggests Relevance to Glioblastoma Pathogenesis and CMTM1 and CMTM3 as Priority Targets Genes Chromosomes & Cancer 54 2015 ), S. 433-443 ISSN: 1045-2257 10.1002/gcc.22255 Dietrich P. , Boßerhoff AK. :Modifying microRNAs--another piece of the melanoma puzzle Pigment Cell & Melanoma Research 28 2015 ), S. 488-9 ISSN: 1755-1471 10.1111/pcmr.12389 Hartl J. , Dietrich P. , Moleda L. , Mueller-Schilling M. , Wiest R. :Neuropeptide Y restores non-receptor-mediated vasoconstrictive action in superior mesenteric arteries in portal hypertension Liver International 35 2015 ), S. 2556-63 ISSN: 1478-3223 10.1111/liv.12874 Ruedel A. , Dietrich P. , Schubert T. , Hofmeister S. , Hellerbrand C. , Boßerhoff AK. :Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts International Journal of Clinical and Experimental Pathology 8 2015 ), S. 4953-62 ISSN: 1936-2625
