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Forschung

Publikationen

Publikationen AG Hannappel

2015

Knop J, App C, Huff T, Iavarone F, Castagnola M, Hannappel E
Identification of PDGF-BB binding to thymosin ?4 by chemical cross-linking.
Expert Opin Biol Ther. 2015;15 Suppl 1: S147-54

Cabras T, Iavarone F, Martelli C, Delfino D, Rossetti DV, Inserra I, Manconi B, Desiderio C, Messana I, Hannappel E, Faa G, Castagnola M
High-resolution mass spectrometry for thymosins detection and characterization.
Expert Opin Biol Ther. 2015;15 Suppl 1: S191-201

2014

App C, Knop J, Huff T, Seebahn A, Becker CM, Iavarone F, Castagnola M, Hannappel E
Peptide labeling with photoactivatable trifunctional cadaverine derivative and identification of interacting partners by biotin transfer.
Anal Biochem. 2014;456: 14-21

Al Haj A, Mazur AJ, Buchmeier S, App C, Theiss C, Silvan U, Schoenenberger CA, Jockusch BM, Hannappel E, Weeds AG, Mannherz HG
Thymosin beta4 inhibits ADF/cofilin stimulated F-actin cycling and hela cell migration: Reversal by active Arp2/3 complex.
Cytoskeleton (Hoboken). 2014;71(2): 95-107

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, M¸ller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Nat Commun. 2014;5: 3970

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, App C, M¸nster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dˆrje F, Rau TT, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease.
Nat Med. 2014;20(3): 313-8

2013

Knop J, App C, Horn AH, Iavarone F, Castagnola M, Hannappel E
High-resolution HPLC-ESI-MS characterization of the contact sites of the actin-thymosin ?(4) complex by chemical and enzymatic cross-linking.
Biochemistry. 2013;52(33): 5553-62

App C, Knop J, Huff T, Sticht H, Hannappel E
Thymosin ?4 and tissue transglutaminase. Molecular characterization of cyclic thymosin ?4.
Protein J. 2013;32(6): 484-92

2012

Knop J, App C, Hannappel E
Antibodies in research of thymosin ?4: investigation of cross-reactivity and influence of fixatives.
Ann N Y Acad Sci. 2012;1270: 105-11

App C, Knop J, Mannherz HG, Hannappel E
Identification of interaction partners of ?-thymosins: application of thymosin ?4 labeled by transglutaminase.
Ann N Y Acad Sci. 2012;1270: 98-104

Goldstein AL, Hannappel E, Sosne G, Kleinman HK
Thymosin ?4: a multi-functional regenerative peptide. Basic properties and clinical applications.
Expert Opin Biol Ther. 2012;12(1): 37-51

2011

Trenkwalder T, Hinkel R, Di Q, Sultana S, Lebherz C, Hannappel E, Bock-Marquette I, Deindl E, Kupatt C
rAAV 2.9 transmitted overexpression of thymosin beta 4 enhances neovascularisation in chronic ischemia via isoform specific PI3-Kinase activity
J Vasc Res. 2011;48 1: 284-284

2010

Hannappel E
Thymosin beta4 and its posttranslational modifications.
Ann N Y Acad Sci. 2010;1194: 27-35

Roeder B, App C, Hannappel E, Mannherz HG
Nuclear translocation of Thymosin ss 4 in He La-cell based in-vitro import assays
Eur J Cell Biol. 2010;89 Suppl. : 41-41

2009

Mannherz HG, Hannappel E
The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family.
Cell Motil Cytoskeleton. 2009;66(10): 839-51

2008

Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, M¸ller S, Willhauck M, Spitzweg C, Gildehaus FJ, M¸nzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.
Circulation. 2008;117(17): 2232-40

Mannherz HG, Dansranjavin T, Gremm D, Mazur A, Sokoll A, Hannappel E, Jockusch B
Thymosin beta 4 inhibits ADF/cofilin stimulated F-actin cycling and cell migration: reversal by the FH2-domain of mDia1
Eur J Cell Biol. 2008;87 Suppl. : 23-23

2007

Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M
Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells.
Ann N Y Acad Sci. 2007;1112: 154-60

Hannappel E
beta-Thymosins.
Ann N Y Acad Sci. 2007;1112: 21-37

Bodendorf S, Born G, Hannappel E
Determination of Thymosin beta4 and Protein in Human Wound Fluid after Abdominal Surgery.
Ann N Y Acad Sci. 2007;1112: 418-24

Zoubek RE, Hannappel E
Influence of the N terminus and the actin-binding motif of thymosin beta4 on its interaction with G-actin.
Ann N Y Acad Sci. 2007;1112: 435-41

Zoubek RE, Hannappel E
Subcellular distribution of thymosin beta4.
Ann N Y Acad Sci. 2007;1112: 442-50

Huff T, M¸ller CS, Hannappel E
Thymosin beta4 is not always the main beta-thymosin in mammalian platelets.
Ann N Y Acad Sci. 2007;1112: 451-7

Villmann C, Sandmeier B, Seeber S, Hannappel E, Pischetsrieder M, Becker CM
Myelin proteolipid protein (PLP) as a marker antigen of central nervous system contaminations for routine food control.
J Agric Food Chem. 2007;55(17): 7114-23

2005

Huff T, Philp D, Gho YS, Hannappel E, Kleinman HK
Beta-thymosins stimulate directional migration of human umbilical vein endothelial cells and promote angiogenesis.
Eur J Cell Biol. 2005;84 Suppl.: 55-55

Goldstein AL, Hannappel E, Kleinman HK
Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues.
Trends Mol Med. 2005;11(9): 421-9

2004

Leeanansaksiri W, DeSimone SK, Huff T, Hannappel E, Huff TF
Thymosin beta4 and its N-terminal tetrapeptide, AcSDKP, inhibit proliferation, and induce dysplastic, non-apoptotic nuclei and degranulation of mast cells.
Chem Biodivers. 2004;1(7): 1091-100

Huff T, Rosorius O, Otto AM, Muller CSG, Hannappel E, Ballweber E, Mannherz HG
Nuclear localization of the G-actin sequestering peptide thymosin beta4
Eur J Cell Biol. 2004;83 Suppl.: 41-41

Huff T, Rosorius O, Otto AM, M¸ller CS, Ballweber E, Hannappel E, Mannherz HG
Nuclear localisation of the G-actin sequestering peptide thymosin beta4.
J Cell Sci. 2004;117(Pt 22): 5333-41