Publikationen
Publikationen AG Sticht
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- Berger E., Jauss RT., Ranells JD., Zonic E., von Wintzingerode L., Wilson A., Wagner J., Tuttle A., Thomas-Wilson A., Schulte B., Rabin R., Pappas J., Odgis JA., Muthaffar O., Mendez-Fadol A., Lynch M., Levy J., Lehalle D., Lake NJ., Krey I., Kozenko M., Knierim E., Jouret G., Jobanputra V., Isidor B., Hunt D., Hsieh TC., Holtz AM., Haack TB., Gold NB., Dunstheimer D., Donge M., Deb W., De La Rosa Poueriet KA., Danyel M., Christodoulou J., Chopra S., Callewaert B., Busche A., Brick L., Bigay BG., Arlt M., Anikar SS., Almohammal MN., Almanza D., Alhashem A., Bertoli-Avella A., Sticht H., Abou Jamra R.:
Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders
In: Genetics in Medicine (2025), Art.Nr.: 101326
ISSN: 1098-3600
DOI: 10.1016/j.gim.2024.101326
- Backert S., Tegtmeyer N., Horn A., Sticht H., Linz B.:
Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA
In: Cell Communication and Signaling 22 (2024), Art.Nr.: 250
ISSN: 1478-811X
DOI: 10.1186/s12964-024-01635-5 - Beierlein F., Horn A., Sticht H., Mokhir A., Imhof P.:
In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2
In: Biomolecules 14 (2024), Art.Nr.: 153
ISSN: 2218-273X
DOI: 10.3390/biom14020153 - Bergner CG., Breur M., Soto-Bernardini MC., Schäfer L., Lier J., Le Duc D., Bundalian L., Schubert S., Brenner D., Kreuz FR., Schulte B., Waisfisz Q., Bugiani M., Köhler W., Sticht H., Abou Jamra R., Van Der Knaap MS.:
Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy
In: Brain 147 (2024), S. 3562-3572
ISSN: 0006-8950
DOI: 10.1093/brain/awae085 - Boonsawat P., Asadollahi R., Niedrist D., Steindl K., Begemann A., Joset P., Bhoj EJ., Li D., Zackai E., Vetro A., Barba C., Guerrini R., Whalen S., Keren B., Khan A., Jing D., Palomares Bralo M., Rikeros Orozco E., Hao Q., Schlott Kristiansen B., Zheng B., Donnelly D., Clowes V., Zweier M., Papik M., Siegel G., Sabatino V., Mocera M., Horn AH., Sticht H., Rauch A.:
Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/β-catenin signaling
In: American Journal of Human Genetics (2024)
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2024.07.016 - Bosch E., Güse E., Kirchner P., Winterpacht A., Walther M., Alders M., Kerkhof J., Ekici AB., Sticht H., Sadikovic B., Reis A., Vasileiou G.:
The missing link: ARID1B non-truncating variants causing Coffin-Siris syndrome due to protein aggregation
In: Human genetics (2024)
ISSN: 0340-6717
DOI: 10.1007/s00439-024-02688-9 - Brand L., Scherer M., tom Dieck T., Lotter S., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Closed Loop Molecular Communication Testbed: Setup, Interference Analysis, and Experimental Results
ICC 2024 - IEEE International Conference on Communications (Denver, CO, 9. Juni 2024 - 13. Juni 2024)
In: ICC 2024 - IEEE International Conference on Communications 2024
DOI: 10.1109/ICC51166.2024.10622231 - Dehm V., Aberle T., Bladé LG., Aprato J., Weider M., Sticht H., Sock E., Wegner M.:
Molecular Analysis of the Differential Activity of Sox8 and Sox10 in Oligodendroglial Cells
In: International Journal of Molecular Sciences 25 (2024), Art.Nr.: 13395
ISSN: 1422-0067
DOI: 10.3390/ijms252413395 - Herbst C., Bothe V., Wegler M., Axer-Schaefer S., Audebert-Bellanger S., Gecz J., Cogne B., Feldman HB., Horn A., Hurst AC., Kelly MA., Kruer MC., Kurolap A., Laquerriere A., Li M., Mark PR., Morawski M., Nizon M., Pastinen T., Polster T., Saugier-Veber P., SeSong J., Sticht H., Stieler JT., Thifffault I., van Eyk CL., Marcorelles P., Vezain-Mouchard M., Abou Jamra R., Oppermann H.:
Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly
In: Human genetics 143 (2024), S. 455-469
ISSN: 0340-6717
DOI: 10.1007/s00439-024-02655-4 - Kohrt S., Baheerathan A., Prokscha J., Zwosta A., Sticht H., Thoma-Kreß A.:
Identification of a Nuclear Localization Signal (NLS) in Human Transcription Elongation Factor ELL2
In: Cell Biochemistry and Function 42 (2024), Art.Nr.: e70019
ISSN: 0263-6484
DOI: 10.1002/cbf.70019 - Krumbholz M., Dolnik A., Sträng E., Ghete T., Skambraks S., Hutter S., Simonis A., Stegelmann F., Suttorp M., Horn A., Sticht H., Haferlach T., Bullinger L., Metzler M.:
A high proportion of germline variants in pediatric chronic myeloid leukemia
In: Molecular Cancer 23 (2024), Art.Nr.: 206
ISSN: 1476-4598
DOI: 10.1186/s12943-024-02109-5 - Linz B., Sticht H., Tegtmeyer N., Backert S.:
Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori
In: Trends in Microbiology 32 (2024), S. 847-857
ISSN: 0966-842X
DOI: 10.1016/j.tim.2024.02.001 - Lux U., Meyer J., Jahn O., Davison A., Babai N., Gießl A., Wartenberg A., Sticht H., Brose N., Reim K., Brandstätter JH.:
Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex
In: Frontiers in Molecular Neuroscience 17 (2024), Art.Nr.: 1308466
ISSN: 1662-5099
DOI: 10.3389/fnmol.2024.1308466 - Marschall M., Schütz M., Wild M., Socher E., Wangen C., Dhotre K., Rawlinson WD., Sticht H.:
Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target
In: Cells 13 (2024), S. 1338
ISSN: 2073-4409
DOI: 10.3390/cells13161338 - Reuter N., Kropff B., CHEN X., Britt WJ., Sticht H., Mach M., Thomas M.:
The Autonomous Fusion Activity of Human Cytomegalovirus Glycoprotein B Is Regulated by Its Carboxy-Terminal Domain
In: Viruses 16 (2024), Art.Nr.: 1482
ISSN: 1999-4915
DOI: 10.3390/v16091482 - Schmid CM., Gregor A., Ruiz A., Manso Bazús C., Herman I., Ammouri F., Kotzaeridou U., McNiven V., Dupuis L., Steindl K., Begemann A., Rauch A., Suter AA., Isidor B., Mercier S., Nizon M., Cogné B., Deb W., Besnard T., Haack TB., Falb RJ., Müller AJ., Linden T., Haldeman-Englert CR., Ockeloen CW., Mattioli F., Reymond A., Ibrahim N., Naz S., Lacaze E., Bassetti JA., Hoefele J., Brunet T., Riedhammer KM., Elloumi HZ., Person R., Zou F., Kahle JJ., Cremer K., Schmidt A., Delrue MA., Almeida PM., Ramos F., Srivastava S., Quinlan A., Robertson S., Manka E., Kuechler A., Spranger S., Nowaczyk MJ., Elshafie RM., Alsharhan H., Hillman PR., Dunnington LA., Braakman HM., McKee S., Moresco A., Ignat AD., Newbury-Ecob R., Banneau G., Patat O., Kuerbitz J., Rzucidlo S., Sell SS., Gordon P., Schuhmann S., Reis A., Halleb Y., Stoeva R., Keren B., Al Masseri Z., Tümer Z., Hammer-Hansen S., Krüger Sølyst S., Steigerwald CG., Abreu NJ., Faust H., Müller-Nedebock A., Tran Mau-Them F., Sticht H., Zweier C.:
Further delineation of the SCAF4-associated neurodevelopmental disorder
In: European Journal of Human Genetics (2024), Art.Nr.: 103
ISSN: 1018-4813
DOI: 10.1038/s41431-024-01760-2 - Sharafutdinov I., Harrer A., Müsken M., Rottner K., Sticht H., Täger C., Naumann M., Tegtmeyer N., Backert S.:
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection
In: Cell Insight 3 (2024), Art.Nr.: 100161
ISSN: 2772-8927
DOI: 10.1016/j.cellin.2024.100161 - Yang F., Begemann A., Reichhart N., Haeckel A., Steindl K., Schellenberger E., Sturm RF., Barth M., Bassani S., Boonsawat P., Courtin T., Delobel B., Gunning B., Hardies K., Jennesson M., Legoff L., Linnankivi T., Prouteau C., Smal N., Spodenkiewicz M., Toelle SP., Van Gassen K., Van Paesschen W., Verbeek N., Ziegler A., Zweier M., Horn AH., Sticht H., Lerche H., Weckhuysen S., Strauß O., Rauch A.:
Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect
In: American Journal of Human Genetics 111 (2024), S. 1184-1205
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2024.04.014
- Ahmad N., Fazeli W., Schließke S., Lesca G., Gokce-Samar Z., Mekbib KY., Jin SC., Burton J., Hoganson G., Petersen A., Gracie S., Granger L., Bartels E., Oppermann H., Kundishora A., Till M., Milleret-Pignot C., Dangerfield S., Viskochil D., Anderson KJ., Palculict TB., Schnur RE., Wentzensen IM., Tiller GE., Kahle KT., Kunz WS., Burkart S., Simons M., Sticht H., Abou Jamra R., Neuser S.:
De Novo Variants in RAB11B Cause Various Degrees of Global Developmental Delay and Intellectual Disability in Children
In: Pediatric Neurology 148 (2023), S. 164-171
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2023.08.023 - Brand L., Scherer M., Lotter S., tom Dieck T., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Switchable Signaling Molecules for Media Modulation: Fundamentals, Applications, and Research Directions
In: IEEE Communications Magazine (2023), S. 1-7
ISSN: 0163-6804
DOI: 10.1109/MCOM.021.2300096 - Breitinger U., Sedky CA., Sticht H., Breitinger HG.:
Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2
In: Virology Journal 20 (2023), Art.Nr.: 142
ISSN: 1743-422X
DOI: 10.1186/s12985-023-02095-y - Conrad M., Horn A., Sticht H.:
Computational Analysis of Histamine Protonation Effects on H1R Binding
In: Molecules 28 (2023), Art.Nr.: 3774
ISSN: 1420-3049
DOI: 10.3390/molecules28093774 - Deubler M., Weißenborn L., Leukel S., Horn A., Eichler J., Sticht H.:
Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides
In: Biology 12 (2023), Art.Nr.: 824
ISSN: 2079-7737
DOI: 10.3390/biology12060824 - Langhammer F., Maroofian R., Badar R., Gregor A., Rochman M., Ratliff JB., Koopmans M., Herget T., Hempel M., Kortüm F., Heron D., Mignot C., Keren B., Brooks S., Botti C., Ben-Zeev B., Argilli E., Sherr EH., Gowda VK., Srinivasan VM., Bakhtiari S., Kruer MC., Salih MA., Kuechler A., Muller EA., Blocker K., Kuismin O., Park KL., Kochhar A., Brown K., Ramanathan S., Clark RD., Elgizouli M., Melikishvili G., Tabatadze N., Stark Z., Mirzaa GM., Ong J., Grasshoff U., Bevot A., von Wintzingerode L., Jamra RA., Hennig Y., Goldenberg P., Al Alam C., Charif M., Boulouiz R., Bellaoui M., Amrani R., Al Mutairi F., Tamim AM., Abdulwahab F., Alkuraya FS., Khouj EM., Alvi JR., Sultan T., Hashemi N., Karimiani EG., Ashrafzadeh F., Imannezhad S., Efthymiou S., Houlden H., Sticht H., Zweier C.:
Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders
In: Genetics in Medicine 25 (2023), Art.Nr.: 100885
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100885 - Reimann T., Müdsam C., Schachtler C., Ince S., Sticht H., Herrmann C., Stürzl M., Kost B.:
The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression
In: Nature Plants (2023)
ISSN: 2055-0278
DOI: 10.1038/s41477-023-01400-5 - Schmid CM., Gregor A., Costain G., Morel CF., Massingham L., Schwab J., Quélin C., Faoucher M., Kaplan J., Procopio R., Saunders CJ., Cohen AS., Lemire G., Sacharow S., O'Donnell-Luria A., Segal RJ., Kianmahd Shamshoni J., Schweitzer D., Ebrahimi-Fakhari D., Monaghan K., Palculict TB., Napier MP., Tao A., Isidor B., Moradkhani K., Reis A., Sticht H., Chung WK., Zweier C.:
LHX2 haploinsufficiency causes a variable neurodevelopmental disorder
In: Genetics in Medicine 25 (2023), Art.Nr.: 100839
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100839 - Schütz M., Cordsmeier A., Wangen C., Horn A., Wyler E., Enßer A., Sticht H., Marschall M.:
The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells.
In: International Journal of Molecular Sciences 24 (2023)
ISSN: 1422-0067
DOI: 10.3390/ijms242417421 - Schütz M., Wangen C., Sommerer M., Kögler M., Eickhoff J., Degenhart C., Klebl B., Naing Z., Egilmezer E., Hamilton ST., Rawlinson WD., Sticht H., Marschall M.:
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
In: Virus Research 335 (2023), Art.Nr.: 199200
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2023.199200 - Sharafutdinov I., Tegtmeyer-Backert N., Linz B., Rohde M., Vieth M., Tay ACY., Lamichhane B., Tuan VP., Fauzia KA., Sticht H., Yamaoka Y., Marshall BJ., Backert S.:
A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development
In: Cell Host & Microbe 31 (2023), S. 1345-1358.e6
ISSN: 1931-3128
DOI: 10.1016/j.chom.2023.06.016 - Zanoni P., Steindl K., Sticht H., Oneda B., Joset P., Ivanovski I., Horn AH., Cabello EM., Laube J., Zweier M., Baumer A., Rauch A., Khan N.:
The genetic landscape and clinical implication of pediatric Moyamoya angiopathy in an international cohort
In: European Journal of Human Genetics (2023)
ISSN: 1018-4813
DOI: 10.1038/s41431-023-01320-0 - Zarzecka U., Tegtmeyer N., Sticht H., Backert S.:
Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain
In: Medical Microbiology and Immunology (2023)
ISSN: 0300-8584
DOI: 10.1007/s00430-023-00766-9 - von Wintzingerode L., Ben-Zeev B., Cesario C., Chan KM., Depienne C., Elpeleg O., Iascone M., Kelley WV., Nassogne MC., Niceta M., Pezzani L., Rahner N., Revencu N., Bekheirnia MR., Santiago-Sim T., Tartaglia M., Thompson ML., Trivisano M., Hentschel J., Sticht H., Abou Jamra R., Oppermann H.:
De novo variants in CNOT9 cause a neurodevelopmental disorder with or without epilepsy.
In: Genetics in Medicine 25 (2023)
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100859
- Aillaud I., Kaniyappan S., Chandupatla RR., Ramirez LM., Alkhashrom S., Eichler J., Horn A., Zweckstetter M., Mandelkow E., Sticht H., Funke SA.:
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
In: Alzheimer's Research and Therapy 14 (2022)
ISSN: 1758-9193
DOI: 10.1186/s13195-022-00959-z - Beudert M., Hahn L., Horn A., Hauptstein N., Sticht H., Meinel L., Luxenhofer R., Gutmann M., Luehmann T.:
Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels
In: Journal of Controlled Release 347 (2022), S. 115-126
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2022.04.028 - Boonsawat P., Horn AHC., Steindl K., Baumer A., Joset P., Kraemer D., Bahr A., Ivanovski I., Cabello EM., Papik M., Zweier M., Oneda B., Sirleto P., Burkhardt T., Sticht H., Rauch A.:
Assessing clinical utility of preconception expanded carrier screening regarding residual risk for neurodevelopmental disorders
In: npj Genomic Medicine 7 (2022), Art.Nr.: 45
ISSN: 2056-7944
DOI: 10.1038/s41525-022-00316-x - Brand L., Garkisch M., Lotter S., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Media Modulation based Molecular Communication
In: IEEE Transactions on Communications (2022), S. 1-1
ISSN: 0090-6778
DOI: 10.1109/TCOMM.2022.3205949 - Breitinger U., Farag NS., Sticht H., Breitinger HG.:
Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2
In: International Journal of Biochemistry and Cell Biology 145 (2022), Art.Nr.: 106185
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2022.106185 - Conrad M., Söldner C., Sticht H.:
Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H1 Receptor
In: International Journal of Molecular Sciences 23 (2022), Art.Nr.: 1420
ISSN: 1422-0067
DOI: 10.3390/ijms23031420 - Gerber CB., Fliedner A., Bartsch O., Berland S., Dewenter M., Haug M., Hayes I., Marin-Reina P., Mark PR., Martinez-Castellano F., Maystadt I., Karadurmus D., Steindl K., Wiesener A., Zweier M., Sticht H., Zweier C.:
Further characterization of Borjeson-Forssman-Lehmann syndrome in females due to de novo variants in PHF6
In: Clinical Genetics (2022)
ISSN: 0009-9163
DOI: 10.1111/cge.14173 - Gregor A., Meerbrei T., Gerstner T., Toutain A., Lynch SA., Stals K., Maxton C., Lemke JR., Bernat JA., Bombei HM., Foulds N., Hunt D., Kuechler A., Beygo J., Stöbe P., Bouman A., Palomares-Bralo M., Santos-Simarro F., Garcia-Minaur S., Pacio-Miguez M., Popp B., Vasileiou G., Hebebrand M., Reis A., Schuhmann S., Krumbiegel M., Brown NJ., Sparber P., Melikyan L., Bessonova L., Cherevatova T., Sharkov A., Shcherbakova N., Dabir T., Kini U., Schwaibold EM., Haack TB., Bertoli M., Hoffjan S., Falb R., Shinawi M., Sticht H., Zweier C.:
De novo missense variants in FBXO11 alter its protein expression and subcellular localization
In: Human Molecular Genetics 31 (2022), S. 440-454
ISSN: 0964-6906
DOI: 10.1093/hmg/ddab265 - Kerker I., Löhr S., Uebe S., Popp B., Vasileiou G., Bowes J., Kirchner P., Becker I., Giardina E., Korendowych E., Ekici AB., Ho P., Behrens F., Kohm M., Schett G., Rech J., Assmann G., Nimeh A., Padyukov L., Alenius GM., Mchugh NJ., Sticht H., Frey B., Burkhardt H., Barton A., Wiesmann da Silva Reis A., Hüffmeier U.:
Common RUNX3 missense variant contributes to psoriatic arthritis by modifying differentiation of CD8(+) T-cells
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2022 - Kicuntod J., Häge S., Hahn F., Sticht H., Marschall M.:
The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors
In: Viruses 14 (2022), Art.Nr.: 1021
ISSN: 1999-4915
DOI: 10.3390/v14051021 - Kloeckner C., Murray JPF., Tavasoli M., Sticht H., Stoltenburg-Didinger G., Scholle LM., Bakhtiari S., Kruer MC., Darvish H., Firouzabadi SG., Pagnozzi A., Shukla A., Girisha KM., Narayanan DL., Kaur P., Maroofian R., Zaki MS., Noureldeen MM., Merkenschlager A., Gburek-Augustat J., Cali E., Banu S., Nahar K., Efthymiou S., Houlden H., Abou Jamra R., Williams J., Mcmaster CR., Platzer K.:
Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly
In: Brain (2022)
ISSN: 0006-8950
DOI: 10.1093/brain/awac074 - Linck-Paulus L., Horn A., Matthies AO., Fischer S., Meister G., Sticht H., Kappelmann-Fenzl M., Boßerhoff AK.:
A novel splice variant of Argonaut 2 affects microRNA target genes and cell viability of melanoma cells
In: JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, HOBOKEN: 2022 - Linck-Paulus L., Meißgeier T., Pieger K., Horn A., Matthies AO., Fischer S., Meister G., Sticht H., Kappelmann-Fenzl M., Boßerhoff AK.:
A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells
In: Cellular and Molecular Life Sciences 79 (2022), Art.Nr.: 475
ISSN: 1420-682X
DOI: 10.1007/s00018-022-04496-8 - Luppe J., Sticht H., Lecoquierre F., Goldenberg A., Gorman KM., Molloy B., Agolini E., Novelli A., Briuglia S., Kuismin O., Marcelis C., Vitobello A., Denomme-Pichon AS., Julia S., Lemke JR., Abou Jamra R., Platzer K.:
Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy
In: European Journal of Human Genetics (2022)
ISSN: 1018-4813
DOI: 10.1038/s41431-022-01269-6 - Lösing J., Haege S., Schütz M., Wagner S., Wardin J., Sticht H., Marschall M.:
'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis
In: Cells 11 (2022)
ISSN: 2073-4409
DOI: 10.3390/cells11244030 - Peter AS., Grüner E., Socher E., Fraedrich K., Richel E., Müller-Schmucker S., Cordsmeier A., Enßer A., Sticht H., Überla K.:
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
In: International Journal of Molecular Sciences 23 (2022)
ISSN: 1422-0067
DOI: 10.3390/ijms23158177 - Platzer K., Sticht H., Bupp C., Ganapathi M., Pereira EM., Le Guyader G., Bilan F., Henderson LB., Lemke JR., Taschenberger H., Brose N., Abou Jamra R., Wojcik SM.:
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission
In: Annals of Neurology (2022)
ISSN: 0364-5134
DOI: 10.1002/ana.26485 - Popp B., Bienvenu T., Giurgea I., Metreau J., Kraus C., Reis A., Fischer J., Bralo MP., Tenorio-Castano J., Lapunzina P., Almoguera B., Lopez-Grondona F., Sticht H., Zweier C.:
The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt-Hopkins syndrome
In: Clinical Genetics (2022)
ISSN: 0009-9163
DOI: 10.1111/cge.14206 - Rahimi MJ., Urban N., Wegler M., Sticht H., Schaefer M., Popp B., Gaunitz F., Morleo M., Nigro V., Maitz S., Mancini GM., Ruivenkamp C., Suk EK., Bartolomaeus T., Merkenschlager A., Koboldt D., Bartholomew D., Stegmann AP., Sinnema M., Duynisveld I., Salvarinova R., Race S., de Vries BB., Trimouille A., Naudion S., Marom D., Hamiel U., Henig N., Demurger F., Rahner N., Bartels E., Hamm JA., Putnam AM., Person R., Abou Jamra R., Oppermann H.:
De novo variants in ATP2B1 lead to neurodevelopmental delay
In: American Journal of Human Genetics 109 (2022), S. 944-952
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2022.03.009 - Rosenhahn E., O'Brien TJ., Zaki MS., Sorge I., Wieczorek D., Rostasy K., Vitobello A., Nambot S., Alkuraya FS., Hashem MO., Alhashem A., Tabarki B., Alamri AS., Al Safar AH., Bubshait DK., Alahmady NF., Gleeson JG., Abdel-Hamid MS., Lesko N., Ygberg S., Correia SP., Wredenberg A., Alavi S., Seyedhassani SM., Ebrahimi Nasab M., Hussien H., Omar TE., Harzallah I., Touraine R., Tajsharghi H., Morsy H., Houlden H., Shahrooei M., Ghavideldarestani M., Abdel-Salam GM., Torella A., Zanobio M., Terrone G., Brunetti-Pierri N., Omrani A., Hentschel J., Lemke JR., Sticht H., Abou Jamra R., Brown AE., Maroofian R., Platzer K.:
Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications
In: American Journal of Human Genetics 109 (2022), S. 1421-1435
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2022.06.008 - Schweininger J., Kriegel M., Häge S., Conrad M., Alkhashrom S., Lösing J., Weiler S., Tillmanns J., Egerer-Sieber C., Decker A., Rovis TL., Eichler J., Sticht H., Marschall M., Muller Y.:
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity
In: Journal of Biological Chemistry 298 (2022), Art.Nr.: 101625
ISSN: 0021-9258
DOI: 10.1016/j.jbc.2022.101625 - Schütz M., Müller R., Socher E., Wangen C., Full F., Wyler E., Wong DD., Scherer M., Stamminger T., Chou S., Rawlinson WD., Hamilton ST., Sticht H., Marschall M.:
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
In: International Journal of Molecular Sciences 23 (2022), S. 11814
ISSN: 1422-0067
DOI: 10.3390/ijms231911814 - Thuma N., Döhler D., Mielenz D., Sticht H., Radtke D., Reimann L., Warscheid B., Vöhringer D.:
A newly identified secreted larval antigen elicits basophil-dependent protective immunity against N. brasiliensis infection
In: Frontiers in Immunology 13 (2022), Art.Nr.: 979491
ISSN: 1664-3224
DOI: 10.3389/fimmu.2022.979491 - Vintschger E., Kraemer D., Joset P., Horn A., Rauch A., Sticht H., Bachmann-Gagescu R.:
Challenges for the implementation of next generation sequencing-based expanded carrier screening: Lessons learned from the ciliopathies
In: European Journal of Human Genetics (2022)
ISSN: 1018-4813
DOI: 10.1038/s41431-022-01267-8 - Wegler M., Jia X., Alders M., Bouman A., Chen J., Duan X., Lauzon JL., Mathijssen IB., Sticht H., Syrbe S., Tan S., Guo H., Abou Jamra R.:
De novo variants in the PABP domain of PABPC1 lead to developmental delay
In: Genetics in Medicine (2022)
ISSN: 1098-3600
DOI: 10.1016/j.gim.2022.04.013 - Weißenborn L., Richel E., Hueseman H., Welzer J., Beck S., Schäfer S., Sticht H., Überla K., Eichler J.:
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein
In: International Journal of Molecular Sciences 23 (2022)
ISSN: 1422-0067
DOI: 10.3390/ijms23116309
- Appelhof B., Wagner M., Hoefele J., Heinze A., Roser T., Koch-Hogrebe M., Roosendaal SD., Dehghani M., Mehrjardi MYV., Torti E., Houlden H., Maroofian R., Rajabi F., Sticht H., Baas F., Wieczorek D., Abou Jamra R.:
Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1
In: European Journal of Human Genetics 29 (2021), S. 411-421
ISSN: 1018-4813
DOI: 10.1038/s41431-020-00749-x - Averdunk L., Sticht H., Surowy H., Luedecke HJ., Koch-Hogrebe M., Alsaif HS., Kahrizi K., Alzaidan H., Alawam BS., Tohary M., Kraus C., Endele S., Wadman E., Kaplan JD., Efthymiou S., Najmabadi H., Reis A., Alkuraya FS., Wieczorek D.:
Correction to: The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype (Journal of Molecular Medicine, (2021), 10.1007/s00109-021-02124-9)
In: Journal of Molecular Medicine (2021)
ISSN: 0946-2716
DOI: 10.1007/s00109-021-02153-4 - Averdunk L., Sticht H., Surowy H., Luedecke HJ., Koch-Hogrebe M., Alsaif HS., Kahrizi K., Alzaidan H., Alawam BS., Tohary M., Kraus C., Endele S., Wadman E., Kaplan JD., Efthymiou S., Najmabadi H., Reis A., Alkuraya FS., Wieczorek D.:
The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype
In: Journal of Molecular Medicine (2021)
ISSN: 0946-2716
DOI: 10.1007/s00109-021-02124-9 - Bachert W., Klotz L., Sticht H., Enz R.:
Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179
In: Neurochemistry International 149 (2021), Art.Nr.: 105150
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2021.105150 - Breitinger U., Ali NK., Sticht H., Breitinger HG.:
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
In: Frontiers in Microbiology 12 (2021), Art.Nr.: 692423
ISSN: 1664-302X
DOI: 10.3389/fmicb.2021.692423 - Breitinger U., Sticht H., Breitinger HG.:
Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols
In: Biological Chemistry (2021)
ISSN: 1431-6730
DOI: 10.1515/hsz-2020-0360 - Durmus H., Mertoğlu E., Sticht H., Ceylaner S., Kulaksızoğlu IB., Hashemolhosseini S., Uçar EÖ., Parman Y.:
Episodic psychosis, ataxia, motor neuropathy with pyramidal signs (PAMP sydrome) caused by a novel mutation in ADPRHL2 (AHR3)
In: Neurological Sciences (2021)
ISSN: 1590-1874
DOI: 10.1007/s10072-021-05100-w - Höring C., Conrad M., Söldner C., Wang J., Sticht H., Strasser A., Miao Y.:
Specific engineered G protein coupling to histamine receptors revealed from cellular assay experiments and accelerated molecular dynamics simulations
In: International Journal of Molecular Sciences 22 (2021), Art.Nr.: 10047
ISSN: 1422-0067
DOI: 10.3390/ijms221810047 - Kicuntod J., Alkhashrom S., Häge S., Diewald B., Müller R., Hahn F., Lischka P., Sticht H., Eichler J., Marschall M.:
Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule
In: Viruses 13 (2021)
ISSN: 1999-4915
DOI: 10.3390/v13030462 - Klöckner C., Sticht H., Zacher P., Popp B., Babcock HE., Bakker DP., Barwick K., Bonfert MV., Bönnemann CG., Brilstra EH., Chung WK., Clarke AJ., Devine P., Donkervoort S., Fraser JL., Friedman J., Gates A., Ghoumid J., Hobson E., Horvath G., Keller-Ramey J., Keren B., Kurian MA., Lee V., Leppig KA., Lundgren J., McDonald MT., McLaughlin HM., McTague A., Mefford HC., Mignot C., Mikati MA., Nava C., Raymond FL., Sampson JR., Sanchis-Juan A., Shashi V., Shieh JT., Shinawi M., Slavotinek A., Stödberg T., Stong N., Sullivan JA., Taylor AC., Toler TL., van den Boogaard MJ., van der Crabben SN., van Gassen KL., van Jaarsveld RH., Van Ziffle J., Wadley AF., Wagner M., Wigby K., Wortmann SB., Zarate YA., Møller RS., Lemke JR., Platzer K.:
Correction to: De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy (Genetics in Medicine, (2020), 10.1038/s41436-020-01020-w)
In: Genetics in Medicine (2021)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01090-w - Kohrt S., Strobel S., Mann M., Sticht H., Fleckenstein B., Thoma-Kreß A.:
Characterizing the interaction between the htlv-1 transactivator tax-1 with transcription elongation factor ell2 and its impact on viral transactivation
In: International Journal of Molecular Sciences 22 (2021), Art.Nr.: 13597
ISSN: 1422-0067
DOI: 10.3390/ijms222413597 - Konieczny A., Conrad M., Ertl FJ., Gleixner J., Gattor AO., Grätz L., Schmidt MF., Neu E., Horn A., Wifling D., Gmeiner P., Clark T., Sticht H., Keller M.:
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide y Y4Receptor Ligands Results in Picomolar Binding Constants
In: Journal of Medicinal Chemistry 64 (2021), S. 16746-16769
ISSN: 0022-2623
DOI: 10.1021/acs.jmedchem.1c01574 - Malhis M., Kaniyappan S., Aillaud I., Chandupatla RR., Ramirez LM., Zweckstetter M., Horn A., Mandelkow E., Sticht H., Funke SA.:
Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display
In: ChemBioChem (2021)
ISSN: 1439-4227
DOI: 10.1002/cbic.202100287 - Peter AS., Roth E., Schulz S., Fraedrich K., Steinmetz T., Damm D., Hauke M., Richel E., Müller-Schmucker S., Habenicht K., Eberlein V., Issmail L., Uhlig N., Dolles S., Grüner E., Peterhoff D., Ciesek S., Hoffmann M., Pöhlmann S., McKay PF., Shattock RJ., Wölfel R., Socher E., Wagner R., Eichler J., Sticht H., Schuh W., Neipel F., Enßer A., Mielenz D., Tenbusch M., Winkler T., Grunwald T., Überla K., Jäck HM.:
A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model
In: European Journal of Immunology (2021), Art.Nr.: eji.202149374
ISSN: 0014-2980
DOI: 10.1002/eji.202149374 - Regensburger D., Tenkerian C., Pürzer V., Schmid B., Wohlfahrt T., Stolzer I., Lopez Posadas R., Günther C., Waldner M., Becker C., Sticht H., Petter K., Flierl C., Gass T., Thoenissen T., Geppert CI., Britzen-Laurent N., Meniel VS., Ramming A., Stürzl M., Naschberger E.:
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease
In: Inflammatory Bowel Diseases (2021)
ISSN: 1078-0998
DOI: 10.1093/ibd/izaa346 - Richard EM., Bakhtiari S., Marsh AP., Kaiyrzhanov R., Wagner M., Shetty S., Pagnozzi A., Nordlie SM., Guida BS., Cornejo P., Magee H., Liu J., Norton BY., Webster RI., Worgan L., Hakonarson H., Li J., Guo Y., Jain M., Blesson A., Rodan LH., Abbott MA., Comi A., Cohen JS., Alhaddad B., Meitinger T., Lenz D., Ziegler A., Kotzaeridou U., Brunet T., Chassevent A., Smith-Hicks C., Ekstein J., Weiden T., Hahn A., Zharkinbekova N., Turnpenny P., Tucci A., Yelton M., Horvath R., Gungor S., Hiz S., Oktay Y., Lochmuller H., Zollino M., Morleo M., Marangi G., Nigro V., Torella A., Pinelli M., Amenta S., Husain RA., Grossmann B., Rapp M., Steen C., Marquardt I., Grimmel M., Grasshoff U., Korenke GC., Owczarek-Lipska M., Neidhardt J., Radio FC., Mancini C., Claps Sepulveda DJ., McWalter K., Begtrup A., Crunk A., Guillen Sacoto MJ., Person R., Schnur RE., Mancardi MM., Kreuder F., Striano P., Zara F., Chung WK., Marks WA., van Eyk CL., Webber DL., Corbett MA., Harper K., Berry JG., MacLennan AH., Gecz J., Tartaglia M., Salpietro V., Christodoulou J., Kaslin J., Padilla-Lopez S., Bilguvar K., Munchau A., Ahmed ZM., Hufnagel RB., Fahey MC., Maroofian R., Houlden H., Sticht H., Mane SM., Rad A., Vona B., Jin SC., Haack TB., Makowski C., Hirsch Y., Riazuddin S., Kruer MC.:
Bi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss
In: American Journal of Human Genetics 108 (2021), S. 2006-2016
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2021.08.003 - Schuhmann S., Koller H., Sticht H., Kraus C., Krumbiegel M., Uebe S., Ekici AB., Reis A., Thiel C.:
Clinical and molecular delineation of spondylocostal dysostosis type 3
In: Clinical Genetics (2021)
ISSN: 0009-9163
DOI: 10.1111/cge.13952 - Schütz M., Steingruber M., Socher E., Müller R., Wagner S., Kögel M., Sticht H., Marschall M.:
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
In: Viruses 13 (2021), S. 1248
ISSN: 1999-4915
DOI: 10.3390/v13071248 - Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation
In: Journal of Cellular Biochemistry (2021)
ISSN: 0730-2312
DOI: 10.1002/jcb.30142 - Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
In: Biomedicines 9 (2021)
ISSN: 2227-9059
DOI: 10.3390/biomedicines9050525
URL: https://www.mdpi.com/2227-9059/9/5/525/xml - Söldner C., Sticht H., Horn A.:
Molecular Simulations and Alzheimer׳s Disease
In: Olaf Wolkenhauer (Hrsg.): Systems Medicine: Integrative, qualitative, and computational approaches, Amsterdam: Elsevier, 2021, S. 54-70
ISBN: 9780128160787
DOI: 10.1016/B978-0-12-801238-3.11541-7 - Thomas M., Kropff B., Schneider A., Winkler T., Görzer I., Sticht H., Britt WJ., Mach M., Reuter N.:
A novel strain-specific neutralizing epitope on glycoprotein H of human cytomegalovirus
In: Journal of Virology 95 (2021), Art.Nr.: e00657-21
ISSN: 0022-538X
DOI: 10.1128/JVI.00657-21 - Zanoni P., Steindl K., Sengupta D., Joset P., Bahr A., Sticht H., Lang-Muritano M., Van Ravenswaaij-Arts CMA., Shinawi M., Andrews M., Attie-Bitach T., Maystadt I., Belnap N., Benoit V., Delplancq G., De Vries BBA., Grotto S., Lacombe D., Larson A., Mourmans J., Ounap K., Petrilli G., Pfundt R., Ramsey K., Blok LS., Tsatsaris V., Vitobello A., Faivre L., Wheeler PG., Wevers MR., Wojcik M., Zweier M., Gozani O., Rauch A.:
Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype
In: Genetics in Medicine (2021)
ISSN: 1098-3600
DOI: 10.1038/s41436-021-01158-1
- Abdelfattah F., Kariminejad A., Kahlert AK., Morrison PJ., Gumus E., Mathews KD., Darbro BW., Amor DJ., Walsh M., Sznajer Y., Weiß L., Weidensee S., Chitayat D., Shannon P., Bermejo-Sánchez E., Riaño-Galán I., Hayes I., Poke G., Rooryck C., Pennamen P., Khung-Savatovsky S., Toutain A., Vuillaume ML., Ghaderi-Sohi S., Kariminejad MH., Weinert S., Sticht H., Zenker M., Schanze D.:
Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders
In: Human Mutation (2020)
ISSN: 1059-7794
DOI: 10.1002/humu.24067 - Begemann A., Sticht H., Begtrup A., Vitobello A., Faivre L., Banka S., Alhaddad B., Asadollahi R., Becker J., Bierhals T., Brown KE., Bruel AL., Brunet T., Carneiro M., Cremer K., Day R., Denommé-Pichon AS., Dyment DA., Engels H., Fisher R., Goh ES., Hajianpour MJ., Haertel LRM., Hauer N., Hempel M., Herget T., Johannsen J., Kraus C., Le Guyader G., Lesca G., Mau-Them FT., McDermott JH., McWalter K., Meyer P., Õunap K., Popp B., Reimand T., Riedhammer KM., Russo M., Sadleir LG., Saenz M., Schiff M., Schuler E., Syrbe S., Van der Ven AT., Verloes A., Willems M., Zweier C., Steindl K., Zweier M., Rauch A.:
New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics
In: Genetics in Medicine (2020)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01011-x - Begemann A., Sticht H., Mcwalter K., Vitobello A., Faivre L., Alhaddad B., Banka S., Becker J., Bierhals T., Brown K., Bruel A., Brunet T., Carneiro M., Cremer K., Day R., Denomme-Pichon A., Dyment DA., Engels H., Fisher R., Glassford M., Goh ES., Hajianpour M., Haertel LRM., Hauer N., Hempel M., Herget T., Kraus C., Le Guyader G., Lesca G., Mau-Them FT., Mcdermott JH., Meyer P., Ounap K., Popp B., Reimand T., Riedhammer KM., Russo M., Sadleir L., Schuler E., Siegel G., Syrbe S., Van Der Ven AT., Verloes A., Willems M., Zweier C., Steindl K., Zweier M., Rauch A.:
Expanding the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and functional proof of aberrant WRC-mediated actin dynamics
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020 - Breitinger U., Weinländer K., Pechmann Y., Langlhofer G., Enz R., Becker CM., Sticht H., Kneussel M., Villmann C., Breitinger HG.:
A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin
In: Journal of Advanced Research (2020)
ISSN: 2090-1232
DOI: 10.1016/j.jare.2020.09.009 - Conrad M., Söldner C., Miao Y., Sticht H.:
Agonist binding and g protein coupling in histamine h2 receptor: A molecular dynamics study
In: International Journal of Molecular Sciences 21 (2020), S. 1-18
ISSN: 1422-0067
DOI: 10.3390/ijms21186693 - Donhauser N., Socher E., Millen S., Heym S., Sticht H., Thoma-Kreß A.:
Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8
In: PLoS Pathogens 16 (2020), Art.Nr.: e1008879
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1008879 - Durmus H., Sticht H., Ceylaner S., Hashemolhosseini S., Deymeer F.:
Rare slow channel congenital myasthenic syndromes without repetitive compound muscle action potential and dramatic response to low dose fluoxetine
In: Acta Neurologica Belgica (2020)
ISSN: 0300-9009
DOI: 10.1007/s13760-020-01505-0 - Durmus H., Sticht H., Ceylaner S., Hashemolhosseini S., Parmn Y.:
EPISODIC PSYCHOSIS, ATAXIA, MOTOR NEUROPATHY CAUSED BY A NOVEL MUTATION IN ADPRHL2
Annual Meeting of the American-Academy-of-Neurology (Toronto, CANADA, 25. April 2020 - 1. Mai 2020)
In: NEUROLOGY, PHILADELPHIA: 2020 - Fliedner A., Gregor A., Ferrazzi F., Ekici AB., Sticht H., Zweier C.:
Loss of PHF6 leads to aberrant development of human neuron-like cells
In: Scientific Reports 10 (2020), Art.Nr.: 19030
ISSN: 2045-2322
DOI: 10.1038/s41598-020-75999-2 - Frey S., Sticht H., Wilsmann-Theis D., Gerschütz A., Wolf K., Löhr S., Haskamp S., Frey B., Hahn M., Ekici AB., Uebe S., Thiel C., Reis A., Burkhardt H., Behrens F., Köhm M., Rech J., Schett G., Assmann G., Kingo K., Kõks S., Mössner R., Prinz JC., Oji V., Schulz P., Munoz LE., Kremer A., Wenzel J., Hüffmeier U.:
Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis
In: Journal of Investigative Dermatology (2020)
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.11.024 - Grosche L., Knippertz I., König C., Royzman D., Wild A., Zinser E., Sticht H., Muller Y., Steinkasserer A., Lechmann M.:
The CD83 Molecule – An Important Immune Checkpoint
In: Frontiers in Immunology 11 (2020), Art.Nr.: 721
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00721 - Haskamp S., Bruns H., Hahn M., Hoffmann M., Gregor A., Löhr S., Hahn J., Ringer M., Flamann C., Frey B., Lesner A., Thiel C., Ekici AB., von Hörsten S., Aßmann G., Riepe C., Euler M., Schäkel K., Philipp S., Prinz JC., Mößner R., Kersting F., Sticherling M., Sefiani A., Lyahyai J., Sondermann W., Oji V., Schulz P., Wilsmann-Theis D., Sticht H., Schett G., Reis A., Uebe S., Frey S., Hüffmeier U., Schauer C.:
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
In: American Journal of Human Genetics 107 (2020), S. 527-538
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2020.07.001 - Hussein RA., Ahmed M., Sticht H., Breitinger HG., Breitinger U.:
Fine-Tuning of Neuronal Ion Channels-Mapping of Residues Involved in Glucose Sensitivity of Recombinant Human Glycine Receptors
In: Acs Chemical Neuroscience (2020)
ISSN: 1948-7193
DOI: 10.1021/acschemneuro.0c00566 - Hüffmeier U., Löhr S., Uebe S., Popp B., Bowes J., Kirchner P., Giardina E., Korendowych E., Ekici AB., Ho P., Behrens F., Koehm M., Schett G., Rech J., Assmann G., Nimeh A., Padyukov L., Alenius G., Mchugh NJ., Sticht H., Burkhardt H., Barton A., Reis A.:
Common RUNX3 missense variant contributes to psoriatic arthritis by affecting splicing and modifying signaling, activation and differentiation of T-cells
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020 - Kloeckner C., Sticht H., Zacher P., Popp B., Babcock HE., Bakker DP., Barwick K., Bonfert M., Bonnemann CG., Brilstra EH., Chung WK., Clarke AJ., Devine P., Donkervoort S., Fraser JL., Friedman J., Gates A., Ghoumid J., Hobson E., Horvath G., Keller-Ramey J., Keren B., Kurian MA., Lee V., Leppig KA., Lundgren J., Mcdonald MT., Mctague A., Mefford HC., Mignot C., Mikati MA., Nava C., Raymond FL., Sampson JR., Sanchis-Juan A., Shashi V., Shieh JTC., Shinawi M., Slavotinek A., Stodberg T., Stong N., Sullivan JA., Taylor AC., Toler TL., Van Den Boogaard MJ., Van Der Crabben SN., Van Gassen KL., Van Jaarsveld RH., Van Ziffle J., Wadley AF., Wagner M., Wigby K., Wortmann SB., Zarate YA., Moller RS., Lemke JR., Platzer K.:
De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy
In: Genetics in Medicine (2020)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01020-w - Marschall M., Häge S., Conrad M., Alkhashrom S., Kicuntod J., Schweininger J., Kriegel M., Loesing J., Tillmanns J., Neipel F., Eichler J., Muller Y., Sticht H.:
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties
In: Viruses 12 (2020)
ISSN: 1999-4915
DOI: 10.3390/v12060683 - Muller Y., Häge S., Alkhashrom S., Höllriegl T., Weigert S., Dolles S., Hof K., Walzer S., Egerer-Sieber C., Conrad M., Holst S., Lösing J., Sonntag E., Sticht H., Eichler J., Marschall M., Marschall M.:
High-resolution crystal structures of two prototypical β- And γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity
In: Journal of Biological Chemistry 295 (2020), S. 3189-3201
ISSN: 0021-9258
DOI: 10.1074/jbc.RA119.011546 - Schuhmann S., Koller H., Sticht H., Kraus C., Krumbiegel M., Uebe S., Ekici AB., Reis A., Thiel CT.:
Further clinical and molecular delineation of spondylocostal dysostosis type 3
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020 - Schütz M., Thomas M., Wangen C., Wagner S., Rauschert L., Errerd T., Kießling M., Sticht H., Milbradt J., Marschall M.:
The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus
In: Virus Research 285 (2020), Art.Nr.: 198023
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2020.198023 - Sharafutdinov I., Soltan Esmaeili D., Harrer A., Tegtmeyer N., Sticht H., Backert S.:
Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8
In: Frontiers in Cellular and Infection Microbiology 10 (2020)
ISSN: 2235-2988
DOI: 10.3389/fcimb.2020.590186 - Söldner C., Socher E., Jamali V., Wicke W., Ahmadzadeh A., Breitinger HG., Burkovski A., Castiglione K., Schober R., Sticht H.:
A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems
In: IEEE Communications Surveys & Tutorials 22 (2020), S. 2765-2800
ISSN: 1553-877X
DOI: 10.1109/COMST.2020.3008819 - Tegtmeyer N., Neddermann M., Lind J., Suneesh Kumar P., Sharafutdinov I., Gutiérrez-Escobar AJ., Brönstrup M., Tegge W., Hong M., Rohde M., Delahay RM., Sticht H., Backert S., Vieth M.:
Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori
In: Cell Reports 32 (2020), Art.Nr.: 108159
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.108159 - Thiel CT., Hauer N., Vogl C., Uebe S., Sticht H., Ekici AB., Kraus C., Dörr HG., Reis A.:
Mono-allelic deleterious variants in autosomal recessive skeletal dysplasia genes are strongly associated with idiopathic short stature
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020 - Zanoni P., Steindl K., Sengupta D., Sticht H., Joset P., Baar A., Van Ravenswaaij-Arts CMA., Shinawi M., Maystadt I., Belnap N., Benoit V., De Vries BBA., Lacombe D., Larson A., Pfundt R., Ramsey K., Blok LS., Wheeler PG., Wevers MR., Gozani O., Rauch A.:
Loss-of-function truncating and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct neurodevelopmental phenotype
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020
- Begemann A., Acuna M., Zweier M., Sticht H., Steindl K., Besnard M., Hackenberg A., Abela L., Plecko B., Yamakawa K., Inoue Y., Baumer A., Joset P., Asadollahi R., Zeilhofer H., Rauch A.:
The functional consequences of SCN2A mutations determine the phenotype
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Begemann A., Acuna MA., Zweier M., Vincent M., Steindl K., Bachmann-Gagescu R., Hackenberg A., Abela L., Plecko B., Kroell-Seger J., Baumer A., Yamakawa K., Inoue Y., Asadollahi R., Sticht H., Zeilhofer HU., Rauch A.:
Further corroboration of distinct functional features in SCN2A variants causing intellectual disability or epileptic phenotypes
In: Molecular Medicine 25 (2019)
ISSN: 1076-1551
DOI: 10.1186/s10020-019-0073-6 - Boonsawat P., Asadollahi R., Niedrist D., Joset P., Wisser J., Budka H., Bode PK., Sticht H., Steindl K., Rauch A.:
Whole-exome sequencing identifies novel causative variants and expands the phenotypic spectrum of PLK4-related primary microcephaly
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Boonsawat P., Joset P., Steindl K., Oneda B., Gogoll L., Azzarello-Burri S., Sheth F., Datar C., Verma I., Puri RD., Zollino M., Bachmann-Gagescu R., Niedrist D., Papik M., Figueiro-Silva J., Masood R., Zweier M., Kraemer D., Lincoln S., Rodan L., Passemard S., Drunat S., Verloes A., Horn A., Sticht H., Steinfeld R., Plecko B., Latal B., Jenni O., Asadollahi R., Rauch A.:
Elucidation of the phenotypic spectrum and genetic landscape in primary and secondary microcephaly
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1038/s41436-019-0464-7 - Boonsawat P., Joset P., Steindl K., Oneda B., Gogoll L., Azzarello-Burri S., Sheth F., Datar C., Verma IC., Puri RD., Zollino M., Bachmann-Gagescu R., Niedrist D., Papik M., Figueiro-Silva J., Masood R., Zweier M., Kraemer D., Lincoln S., Rodan L., Passemard S., Drunat S., Verloes A., Horn A., Sticht H., Steinfeld R., Plecko B., Latal B., Jenni O., Asadollahi R., Rauch A.:
Elucidation of the phenotypic spectrum and genetic landscape in primary and secondary microcephaly
In: Genetics in Medicine 21 (2019), S. 2043-2058
ISSN: 1098-3600
DOI: 10.1038/s41436-019-0464-7 - Harrer A., Buecker R., Böhm M., Zarzecka U., Tegtmeyer N., Sticht H., Schulzke JD., Backert S.:
Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
In: Gut Pathogens 11 (2019)
ISSN: 1757-4749
DOI: 10.1186/s13099-019-0283-z - Hauer N., Popp B., Taher L., Vogl C., Dhandapany PS., Büttner C., Uebe S., Sticht H., Ferrazzi F., Ekici AB., De Luca A., Klinger P., Kraus C., Zweier C., Wiesener A., Jamra RA., Kunstmann E., Rauch A., Wieczorek D., Jung AM., Rohrer TR., Zenker M., Dörr HG., Reis A., Thiel C.:
Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature
In: European journal of human genetics (2019)
ISSN: 1018-4813
DOI: 10.1038/s41431-019-0362-0 - Hauer N., Vogl C., Popp B., Buettner C., Uebe S., Sticht H., Ekici AB., Klinger P., Kraus C., Krumbiegel M., Wiesener A., Dörr HG., Wiesmann da Silva Reis A., Thiel C.:
Exploring the phenotypical spectrum of BRD4 defects
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Horn S., Au M., Basel-Salmon L., Bayrak-Toydemir P., Chapin A., Cohen L., Elting MW., Graham JM., Gonzaga-Jauregui C., Konen O., Holzer M., Lemke J., Miller CE., Rey LK., Wolf NI., Weiss MM., Waisfisz Q., Mirzaa GM., Wieczorek D., Sticht H., Abou Jamra R.:
De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures
In: Brain 142 (2019), S. 3351-3359
ISSN: 0006-8950
DOI: 10.1093/brain/awz264 - Hüffmeier U., Sticht H., Wenzel J., Wilsmann-Theis D., Wolff K., Löhr S., Frey B., Hahn M., Ekici AB., Uebe S., Thiel C., Wiesmann da Silva Reis A., Prinz J., Oji V., Schulz P., Kingo K., Koks S., Moessner R., Munoz LE., Kremer A., Frey S.:
Rare frameshift mutation in SERPINA3 contributes to generalized pustular psoriasis
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Iqbal Z., Tawamie H., Ba W., Reis A., Halak BA., Sticht H., Uebe S., Kasri NN., Riazuddin S., van Bokhoven H., Abou Jamra R.:
Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia
In: Genetics in Medicine (2019)
ISSN: 1098-3600
DOI: 10.1038/s41436-018-0415-8 - Konrad E., Nardini N., Caliebe A., Nagel I., Young D., Horvath G., Santoro SL., Shuss C., Ziegler A., Bonneau D., Kempers M., Pfundt R., Legius E., Bouman A., Stuurman KE., Õunap K., Pajusalu S., Wojcik MH., Vasileiou G., Le Guyader G., Schnelle HM., Berland S., Zonneveld-Huijssoon E., Kersten S., Gupta A., Blackburn PR., Ellingson MS., Ferber MJ., Dhamija R., Klee EW., McEntagart M., Lichtenbelt KD., Kenney A., Vergano SA., Abou Jamra R., Platzer K., Ella Pierpont M., Khattar D., Hopkin RJ., Martin RJ., Jongmans MC., Chang VY., Martinez-Agosto JA., Kuismin O., Kurki MI., Pietiläinen O., Palotie A., Maarup TJ., Johnson DS., Venborg Pedersen K., Laulund LW., Lynch SA., Blyth M., Prescott K., Canham N., Ibitoye R., Brilstra EH., Shinawi M., Fassi E., Sticht H., Gregor A., Van Esch H., Zweier C.:
CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum
In: Genetics in Medicine 21 (2019), S. 2723-2733
ISSN: 1098-3600
DOI: 10.1038/s41436-019-0585-z - Krichel C., Möckel C., Schillinger O., Huesgen PF., Sticht H., Strodel B., Weiergräber OH., Willbold D., Neudecker P.:
Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
In: Scientific Reports 9 (2019), S. 14167-
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48155-8 - Le Duc D., Giulivi C., Hiatt SM., Napoli E., Panoutsopoulos A., De Crescenzo A., Kotzaeridou U., Syrbe S., Anagnostou E., Azage M., Bend R., Begtrup A., Brown NJ., Buettner B., Cho MT., Cooper GM., Doering JH., Dubourg C., Everman DB., Hildebrand MS., Santos FJR., Kellam B., Keller-Ramey J., Lemke JR., Liu S., Niyazov D., Payne K., Person R., Quelin C., Schnur RE., Smith BT., Strober J., Walker S., Wallis M., Walsh L., Yang S., Yuen R., Ziegler A., Sticht H., Pride MC., Martinez-Cerdeno V., Silverman J., Scherer SW., Zarbalis KS., Abou Jamra R.:
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1093/brain/awz198 - Le Duc D., Giulivi C., Hiatt SM., Napoli E., Panoutsopoulos A., Harlan De Crescenzo A., Kotzaeridou U., Syrbe S., Anagnostou E., Azage M., Bend R., Begtrup A., Brown NJ., Büttner B., Cho MT., Cooper GM., Doering JH., Dubourg C., Everman DB., Hildebrand MS., Santos FJR., Kellam B., Keller-Ramey J., Lemke JR., Liu S., Niyazov D., Payne K., Person R., Quélin C., Schnur RE., Smith BT., Strober J., Walker S., Wallis M., Walsh L., Yang S., Yuen RK., Ziegler A., Sticht H., Pride MC., Orosco L., Martínez-Cerdeño V., Silverman JL., Crawley JN., Scherer SW., Zarbalis KS., Jamra R.:
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size
In: Brain 142 (2019), S. 2617-2630
ISSN: 0006-8950
DOI: 10.1093/brain/awz198 - Müller T., Gierke K., Joachimsthaler A., Sticht H., Izsvak Z., Hamra FK., Fejtová A., Ackermann F., Garner CC., Kremers J., Brandstätter JH., Regus-Leidig H.:
A Multiple Piccolino-RIBEYE Interaction Supports Plate-Shaped Synaptic Ribbons in Retinal Neurons
In: Journal of Neuroscience 39 (2019), S. 2606-2619
ISSN: 0270-6474
DOI: 10.1523/JNEUROSCI.2038-18.2019 - Papuc S., Abela L., Steindl K., Begemann A., Simmons T., Schmitt B., Zweier M., Oneda B., Socher E., Crowther L., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor M., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and high-resolution copy number study
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Papuc SM., Abela L., Steindl K., Begemann A., Simmons TL., Schmitt B., Zweier M., Oneda B., Socher E., Crowther LM., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor MC., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study
In: European journal of human genetics 27 (2019), S. 408-421
ISSN: 1018-4813
DOI: 10.1038/s41431-018-0299-8 - Platzer K., Sticht H., Edwards SL., Allen W., Angione KM., Bonati MT., Brasington C., Cho MT., Demmer LA., Falik-Zaccai T., Gamble CN., Hellenbroich Y., Iascone M., Kok F., Mahida S., Mandel H., Marquardt T., Mcwalter K., Panis B., Pepler A., Pinz H., Ramos L., Shinde DN., Smith-Hicks C., Stegmann APA., Stoebe P., Stumpel CTRM., Wilson C., Lemke JR., Di Donato N., Miller KG., Abou Jamra R.:
De novo variants in MAPK8IP3 cause intellectual disability with variable brain anomalies
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1016/j.ajhg.2018.12.008 - Platzer K., Sticht H., Edwards SL., Allen W., Angione KM., Bonati MT., Brasington C., Cho MT., Demmer LA., Falik-Zaccai T., Gamble CN., Hellenbroich Y., Iascone M., Kok F., Mahida S., Mandel H., Marquardt T., Mcwalter K., Panis B., Pepler A., Pinz H., Ramos L., Shinde DN., Smith-Hicks C., Stegmann APA., Stoebe P., Stumpel CTRM., Wilson C., Lemke JR., Di Donato N., Miller KG., Jamra R.:
De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies
In: American Journal of Human Genetics 104 (2019), S. 203-212
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2018.12.008 - Reuter MS., Jobling R., Chaturvedi RR., Manshaei R., Costain G., Heung T., Curtis M., Hosseini SM., Liston E., Lowther C., Oechslin E., Sticht H., Thiruvahindrapuram B., Van Mil S., Wald RM., Walker S., Marshall CR., Silversides CK., Scherer SW., Kim RH., Bassett AS.:
Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot
In: Genetics in Medicine 21 (2019), S. 1001-1007
ISSN: 1098-3600
DOI: 10.1038/s41436-018-0260-9 - Steindl K., Kraemer D., Gogoll L., Zanoni P., Sticht H., Rauch A.:
Phenotype of the first patient harboring a de novo in-frame deletion in the LisH (LIS1 homology) domain of the WDR26 gene
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Steingruber M., Keller L., Socher E., Ferre S., Hesse AM., Coute Y., Hahn F., Buescher N., Plachter B., Sticht H., Marschall M.:
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
In: Journal of Biological Chemistry 294 (2019), S. 6188-6203
ISSN: 0021-9258
DOI: 10.1074/jbc.RA118.007049 - Straub J., Konrad E., Grüner J., Toutain A., Bok LA., Cho MT., Crawford HP., Dubbs H., Douglas G., Jobling R., Johnson D., Krock B., Mikati MA., Nesbitt A., Nicolai J., Phillips M., Poduri A., Ortiz-Gonzales XR., Powis Z., Santani A., Smith L., Stegmann APA., Stumpel C., Vreeburg M., Study DDD., Fliedner A., Gregor A., Sticht H., Zweier C.:
De novo missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Suneesh Kumar P., Tegtmeyer N., Arnold IC., Lind J., Neddermann M., Falkeis-Veits C., Chattopadhyay S., Brönstrup M., Tegge W., Hong M., Sticht H., Müller A., Backert S., Vieth M.:
T4SS-dependent TLR5 activation by Helicobacter pylori infection
In: Nature Communications 10 (2019), Art.Nr.: 5717
ISSN: 2041-1723
DOI: 10.1038/s41467-019-13506-6 - Söldner C., Horn A., Sticht H.:
A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes
In: International Journal of Molecular Sciences 20 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20081970 - Tenkerian C., Regensburger D., Langer V., Klingler A., Borau A., Sticht H., Ramming A., Wohlfahrt T., Schmid B., Meniel V., Grützmann R., Britzen-Laurent N., Schellerer V., Stürzl M., Naschberger E.:
SPARCL1 is an angiocrine inhibitor of tumorigenesis in colorectal carcinoma
AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology (Atlanta, GA, 29. März 2019 - 3. April 2019)
In: CANCER RESEARCH, PHILADELPHIA: 2019
DOI: 10.1158/1538-7445.AM2019-195 - Thiel C., Hauer N., Vogl C., Ahmadian R., Dhandapany PS., Popp B., Buettner C., Ube S., Sticht H., Ferrazzi F., Ekici AB., De Luca A., Schoeller E., Schuhmann S., Heath KE., Hisado-Oliva A., Klinger P., Boppudi S., Kelkel J., Jung AM., Kraus C., Trautmann U., Wiesener A., Kutsche K., Rauch A., Wieczorek D., Rohrer T., Zenker M., Dörr HG., Wiesmann da Silva Reis A.:
Identification of novel candidate genes for idiopathic short stature using whole exome sequencing
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019 - Zweier M., Begemann A., Mcwalter K., Cho MT., Abela L., Banka S., Behring B., Berger A., Brown CW., Carneiro M., Chen J., Cooper GM., Finnila CR., Sacoto MJG., Henderson A., Hüffmeier U., Joset P., Kerr B., Lesca G., Leszinski GS., Mcdermott JH., Meltzer MR., Monaghan KG., Mostafavi R., Ounap K., Plecko B., Powis Z., Purcarin G., Reimand T., Riedhammer KM., Schreiber JM., Sirsi D., Wierenga KJ., Wojcik MH., Papuc SM., Steindl K., Sticht H., Rauch A.:
Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1038/s41431-018-0331-z - Zweier M., Begemann A., Mcwalter K., Cho MT., Abela L., Banka S., Behring B., Berger A., Brown CW., Carneiro M., Chen J., Cooper GM., Finnila CR., Sacoto MJG., Henderson A., Hüffmeier U., Joset P., Kerr B., Lesca G., Leszinski GS., Mcdermott JH., Meltzer MR., Monaghan KG., Mostafavi R., Ounap K., Plecko B., Powis Z., Purcarin G., Reimand T., Riedhammer KM., Schreiber JM., Sirsi D., Wierenga KJ., Wojcik MH., Papuc SM., Steindl K., Sticht H., Rauch A.:
Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures
In: European journal of human genetics 27 (2019), S. 747-759
ISSN: 1018-4813
DOI: 10.1038/s41431-018-0331-z
- Albrecht N., Tegtmeyer N., Sticht H., Skorko-Glonek J., Backert S.:
Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation
In: Frontiers in Microbiology 9 (2018)
ISSN: 1664-302X
DOI: 10.3389/fmicb.2018.00642 - Diewald B., Socher E., Söldner C., Sticht H.:
Conformational Dynamics of Herpesviral NEC Proteins in Different Oligomerization States
In: International Journal of Molecular Sciences 19 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19102908 - Gregor A., Sadleir LG., Asadollahi R., Azzarello-Burri S., Battaglia A., Ousager LB., Boonsawat P., Bruel AL., Buchert R., Calpena E., Cogne B., Dallapiccola B., Distelmaier F., Elmslie F., Faivre L., Haack TB., Harrison V., Henderson A., Hunt D., Isidor B., Joset P., Kumada S., Lachmeijer AMA., Lees M., Lynch SA., Martinez F., Matsumoto N., Mcdougall C., Mefford HC., Miyake N., Myers CT., Moutton S., Nesbitt A., Novelli A., Orellana C., Rauch A., Rosello M., Saida K., Santani AB., Sarkar A., Scheffer IE., Shinawi M., Steindl K., Symonds JD., Zackai EH., Univ WCMGDDD., Reis A., Sticht H., Zweier C.:
De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder
In: American Journal of Human Genetics 103 (2018), S. 305-316
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2018.07.003 - Hauer N., Popp B., Schoeller E., Schuhmann S., Heath KE., Hisado-Oliva A., Klinger P., Kraus C., Trautmann U., Zenker M., Zweier C., Wiesener A., Abou Jamra R., Kunstmann E., Wieczorek D., Uebe S., Ferrazzi F., Büttner C., Ekici AB., Rauch A., Sticht H., Dörr HG., Reis A., Thiel C.:
Clinical relevance of systematic phenotyping and exome sequencing in patients with short stature
In: Genetics in Medicine 20 (2018), S. 630-638
ISSN: 1098-3600
DOI: 10.1038/gim.2017.159 - Ilyaskin A., Kirsch S., Böckmann R., Sticht H., Korbmacher C., Härteis S., Diakov A.:
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids.
In: Pflügers Archiv: European Journal of Physiology (2018)
ISSN: 0031-6768
DOI: 10.1007/s00424-018-2142-z - Leal A., Bogantes-Ledezma S., Ekici AB., Uebe S., Thiel C., Sticht H., Berghoff M., Berghoff C., Morera B., Meisterernst M., Reis A.:
The polynucleotide kinase 3'-phosphatase gene (PNKP) is involved in Charcot-Marie-Tooth disease (CMT2B2) previously related to MED25
In: Neurogenetics 19 (2018), S. 215-225
ISSN: 1364-6745
DOI: 10.1007/s10048-018-0555-7 - Milbradt J., Sonntag E., Wagner S., Strojan H., Wangen C., Rovis TL., Lisnic B., Jonjic S., Sticht H., Britt WJ., Schlötzer-Schrehardt U., Marschall M.:
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
In: Viruses 10 (2018)
ISSN: 1999-4915
DOI: 10.3390/v10010035 - Namakchian M., Kaßler K., Sticht H., Hensel M., Deiwick J.:
Structure-based functional analysis of effector protein SifA in living cells reveals motifs important for Salmonella intracellular proliferation
In: International Journal of Medical Microbiology 308 (2018), S. 84-96
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2017.09.004 - Sandmann A., Sticht H.:
Probing the role of intercalating protein sidechains for kink formation in DNA
In: PLoS ONE 13 (2018)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0192605 - Selch S., Chafai A., Sticht H., Birkenfeld AL., Fromm M., König J.:
Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-29547-8 - Straub J., Konrad E., Grüner J., Toutain A., Bok LA., Cho MT., Crawford HP., Dubbs H., Douglas G., Jobling R., Johnson D., Krock B., Mikati MA., Nesbitt A., Nicolai J., Phillips M., Poduri A., Ortiz-Gonzalez XR., Powis Z., Santani A., Smith L., Stegmann APA., Stumpel C., Vreeburg M., Fliedner A., Gregor A., Sticht H., Zweier C.:
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila
In: American Journal of Human Genetics 102 (2018), S. 44-57
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2017.11.008 - Söldner C., Horn A., Sticht H.:
Binding of histamine to the H1 receptora molecular dynamics study
In: Journal of Molecular Modeling 24 (2018)
ISSN: 1610-2940
DOI: 10.1007/s00894-018-3873-7 - Söldner C., Horn A., Sticht H.:
Interaction of Glycolipids with the Macrophage Surface Receptor Mincle - a Systematic Molecular Dynamics Study
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-23624-8 - Unterer B., Wiesmann V., Gunasekaran M., Sticht H., Tenkerian C., Behrens J., Leone M., Engel F., Britzen-Laurent N., Naschberger E., Wittenberg T., Stürzl M.:
IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD
In: Biochemical Journal 475 (2018), S. 2955-2967
ISSN: 0264-6021
DOI: 10.1042/BCJ20180123 - Weerasekera D., Stengel F., Sticht H., De Mattos Guaraldi AL., Burkovski A., Azevedo Antunes de Oliveira C.:
The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems
In: BMC Microbiology 18 (2018), S. 106
ISSN: 1471-2180
DOI: 10.1186/s12866-018-1247-z
- Asadollahi R., Zweier M., Gogoll L., Schiffmann R., Sticht H., Steindl K., Rauch A.:
Genotype-phenotype evaluation of MED13L defects in the light of a novel truncating and a recurrent missense mutation
In: European Journal of Medical Genetics 60 (2017), S. 451-464
ISSN: 1769-7212
DOI: 10.1016/j.ejmg.2017.06.004 - Bootz A., Karbach A., Spindler J., Kropff B., Reuter N., Sticht H., Winkler T., Britt WJ., Mach M.:
Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus
In: PLoS Pathogens 13 (2017)
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1006601 - Brechet A., Buchert R., Schwenk J., Boudkkazi S., Zolles G., Siquier-Pernet K., Schaber I., Bildl W., Saadi A., Bole-Feysot C., Nitschke P., Reis A., Sticht H., Al-Sanna'A N., Rolfs A., Kulik A., Schulte U., Colleaux L., Abou Jamra R., Fakler B.:
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
In: Nature Communications 8 (2017), S. 15910
ISSN: 2041-1723
DOI: 10.1038/ncomms15910 - Hauer N., Sticht H., Boppudi S., Büttner C., Kraus C., Trautmann U., Zenker M., Zweier C., Wiesener A., Abou Jamra R., Wieczorek D., Kelkel J., Jung AM., Uebe S., Ekici AB., Rohrer T., Reis A., Dörr HG., Thiel C.:
Genetic screening confirms heterozygous mutations in ACAN as a major cause of idiopathic short stature
In: Scientific Reports 7 (2017), S. 12225
ISSN: 2045-2322
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Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83
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Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions
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A Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica
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The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids
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The genetic basis for most patients with pustular skin disease remains elusive
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Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
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Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
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Confirmation of mutations inPROSCas a novel cause of vitamin B 6 -dependent epilepsy
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Probing the potential of CnaB-type domains for the design of tag/catcher systems
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Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID
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Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders
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Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry
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Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly
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N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics
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Modulation of Recombinant Human ?1 Glycine Receptors by Mono- and Disaccharides: A Kinetic Study
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Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly
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Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease
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Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1)
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The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors
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Channel Estimation for Diffusive Molecular Communications
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Channel estimation techniques for diffusion-based molecular communications
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Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains
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CHARACTERIZATION OF THE SPYTAG - SPY-CATCHER INTERACTION
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Expanding the clinical spectrum of COL1A1 mutations in different forms of glaucoma
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The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress
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Amyloid-? dimers in the absence of plaque pathology impair learning and synaptic plasticity
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The pH-dependent client release from the collagen-specific chaperone HSP47 is triggered by a tandem histidine pair
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Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
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Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations
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Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states
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A severe congenital myasthenic syndrome with "dropped head" caused by novel MUSK mutations
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Synthetic Peptides as Protein Mimics
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Binding properties of SUMO-interacting motifs (SIMs) in yeast
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DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects
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Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European Patients
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De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females
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Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations
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A Peroxisomal Disorder of Severe Intellectual Disability, Epilepsy, and Cataracts Due to Fatty Acyl-CoA Reductase 1 Deficiency
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Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity
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Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior
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Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms
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Thymosin ?4 and tissue transglutaminase. Molecular characterization of cyclic thymosin ?4
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Characterization of a single-chain variable fragment recognizing a linear epitope of a?: a biotechnical tool for studies on Alzheimer's disease?
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HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop
In: PLoS ONE 8 (2013), S. e54452
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0054452 - Graf L., Webel R., Wagner S., Hamilton ST., Rawlinson WD., Sticht H., Marschall M.:
The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins
In: Viruses 5 (2013), S. 3213-30
ISSN: 1999-4915
DOI: 10.3390/v5123213 - Gregor A., Oti M., Kouwenhoven EN., Hoyer J., Sticht H., Ekici AB., Kjaergaard S., Rauch A., Stunnenberg HG., Uebe S., Vasileiou G., Reis A., Zhou H., Zweier C.:
De novo mutations in the genome organizer CTCF cause intellectual disability
In: American Journal of Human Genetics 93 (2013), S. 124-31
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2013.05.007 - Grießl M., Schmid B., Kaßler K., Braunsmann C., Ritter R., Barlag B., Stierhof YD., Sturm KU., Danzer CA., Wagner C., Schaeffer TE., Sticht H., Hensel M., Muller Y.:
Structural insight into the giant Ca²?-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells
In: Structure 21 (2013), S. 741-52
ISSN: 0969-2126
DOI: 10.1016/j.str.2013.02.020 - Grosch M., Gruener B., Spranger S., Stuetz AM., Rausch T., Korbel JO., Seelow D., Nuernberg P., Sticht H., Lausch E., Zabel B., Winterpacht A., Tagariello A.:
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype
In: Matrix Biology 32 (2013), S. 387-92
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2013.05.001 - Hofmann K., Zweier M., Sticht H., Zweier C., Wittmann W., Hoyer J., Uebe S., Van Haeringen A., Thiel C., Ekici AB., Reis A., Rauch A.:
Biallelic SEMA3A defects cause a novel type of syndromic short stature
In: American Journal of Medical Genetics Part A 161A (2013), S. 2880-9
ISSN: 1552-4825
DOI: 10.1002/ajmg.a.36250 - Husar-Memmer E., Ekici AB., Al Kaissi A., Sticht H., Manger B., Schett G., Zwerina J.:
Premature Osteoarthritis as Presenting Sign of Type II Collagenopathy: A Case Report and Literature Review
In: Seminars in Arthritis and Rheumatism 42 (2013), S. 355-60
ISSN: 0049-0172
DOI: 10.1016/j.semarthrit.2012.05.002 - Jardin C., Stefani A., Eberhardt M., Huber J., Sticht H.:
An information-theoretic classification of amino acids for the assessment of interfaces in protein-protein docking
In: Journal of Molecular Modeling 19 (2013), S. 3901-10
ISSN: 1610-2940
DOI: 10.1007/s00894-013-1916-7 - Kahler A., Sticht H., Horn A.:
Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study
In: PLoS ONE 8 (2013), S. e70521
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0070521 - Koerber A., Moessner R., Renner R., Sticht H., Wilsmann-Theis D., Schulz P., Sticherling M., Traupe H., Hüffmeier U.:
Mutations in IL36RN in patients with generalized pustular psoriasis
In: Journal of Investigative Dermatology 133 (2013), S. 2634-7
ISSN: 0022-202X
DOI: 10.1038/jid.2013.214 - Rauh R., Söll D., Härteis S., Diakov A., Nesterov V., Krüger B., Sticht H., Korbmacher C.:
A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect
In: American Journal of Physiology-Lung Cellular and Molecular Physiology 304 (2013), S. L43-55
ISSN: 1040-0605
DOI: 10.1152/ajplung.00093.2012 - Scherer M., Reuter N., Wagenknecht N., Otto V., Sticht H., Stamminger T.:
Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments
In: Journal of General Virology 94 (2013), S. 1373-84
ISSN: 0022-1317
DOI: 10.1099/vir.0.051078-0 - Schmeiser C., Borst E., Sticht H., Marschall M., Milbradt J.:
The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import
In: Journal of General Virology 94 (2013), S. 2056-69
ISSN: 0022-1317
DOI: 10.1099/vir.0.052571-0 - Seebahn A., Sticht H., Enz R.:
Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors
In: Methods in Enzymology 520 (2013), S. 257-79
ISSN: 0076-6879
DOI: 10.1016/B978-0-12-391861-1.00012-5 - Spindler N., Ruecker P., Pötzsch S., Diestel U., Sticht H., Martin-Parras L., Winkler T., Mach M.:
Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus
In: Journal of Virology 87 (2013), S. 8927-39
ISSN: 0022-538X
DOI: 10.1128/JVI.00434-13 - Xiang W., Weisbach VG., Sticht H., Seebahn A., Bussmann J., Zimmermann R., Becker CM.:
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes
In: Archives of Biochemistry and Biophysics 529 (2013), S. 34-44
ISSN: 0003-9861
DOI: 10.1016/j.abb.2012.11.002 - de Jong SJ., Albrecht JC., Giehler F., Kieser A., Sticht H., Biesinger B.:
Noncanonical NF-?B activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif
In: Science Signaling 6 (2013), S. ra27
ISSN: 1937-9145
DOI: 10.1126/scisignal.2003309
- Härteis S., Schaal D., Brauer F., Brueschke S., Schweimer K., Rauh R., Sticht H., Roesch P., Schwarzinger S., Korbmacher C.:
An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation
In: Cellular Physiology and Biochemistry 29 (2012), S. 761-74
ISSN: 1015-8987
DOI: 10.1159/000312590 - Jardin C., Sticht H.:
Identification of the structural features that mediate binding specificity in the recognition of STAT proteins by dual-specificity phosphatases
In: Journal of Biomolecular Structure & Dynamics 29 (2012), S. 777-92
ISSN: 0739-1102
DOI: 10.1080/07391102.2012.10507413 - Mazumder ED., Jardin C., Vogel B., Heck E., Scholz B., Lengenfelder D., Sticht H., Enßer A.:
A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip
In: PLoS ONE 7 (2012), S. e34306
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034306 - Meier J., Kaßler K., Sticht H., Eichler J.:
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
In: Beilstein Journal of Organic Chemistry 8 (2012), S. 1858-66
ISSN: 1860-5397
DOI: 10.3762/bjoc.8.214 - Milbradt J., Auerochs S., Sevvana M., Muller Y., Sticht H., Marschall M.:
Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53
In: Journal of Biological Chemistry 287 (2012), S. 24004-16
ISSN: 0021-9258
DOI: 10.1074/jbc.M111.331207 - Mueller-Schiffmann A., Sticht H., Korth C.:
Hybrid compounds: from simple combinations to nanomachines
In: Biodrugs 26 (2012), S. 21-31
ISSN: 1173-8804
DOI: 10.2165/11597630-000000000-00000 - Othersen O., Stefani A., Huber J., Sticht H.:
Application of information theory to feature selection in protein docking
In: Journal of Molecular Modeling 18 (2012), S. 1285-97
ISSN: 1610-2940
DOI: 10.1007/s00894-011-1157-6 - Pasutto F., Keller KE., Weisschuh N., Sticht H., Samples JR., Yang YF., Zenkel M., Schlötzer-Schrehardt U., Mardin CY., Frezzotti P., Edmunds B., Kramer PL., Gramer E., Reis A., Acott TS., Wirtz MK.:
Variants in ASB10 are associated with open-angle glaucoma
In: Human Molecular Genetics 21 (2012), S. 1336-49
ISSN: 0964-6906
DOI: 10.1093/hmg/ddr572 - Tagariello A., Breuer C., Birkner Y., Schmidt S., Koch AM., Cesnjevar R., Rueffer A., Dittrich S., Schneider H., Winterpacht A., Sticht H., Doetsch J., Toka O.:
Functional null mutations in the gonosomal homologue gene TBL1Y are associated with non-syndromic coarctation of the aorta
In: Current Molecular Medicine 12 (2012), S. 199-205
ISSN: 1566-5240
DOI: 10.2174/156652412798889027 - Webel R., Solbak SMO., Held C., Milbradt J., Groß A., Eichler J., Wittenberg T., Jardin C., Sticht H., Fossen T., Marschall M.:
Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-? binding
In: Journal of General Virology 93 (2012), S. 1756-68
ISSN: 0022-1317
DOI: 10.1099/vir.0.040592-0
- Duetting E., Schroeder-Kress N., Sticht H., Enz R.:
Sumo E3 ligases are expressed in the retina and regulate sumoylation of the metabotropic glutamate receptor 8b.
In: Biochemical Journal (2011), S. 365-371
ISSN: 0264-6021
DOI: 10.1042/BJ20101854 - Haberlova J., Mazanec R., Ridzon P., Barankova L., Nuernberg G., Nuernberg P., Sticht H., Hühne K., Seeman P., Rautenstrauss B.:
Phenotypic variability in a large Czech family with a Dynamin 2-associated Charcot-Marie-Tooth neuropathy
In: Journal of Neurogenetics 25 (2011), S. 182-8
ISSN: 0167-7063
DOI: 10.3109/01677063.2011.627484 - Hochdoerffer K., Maerz-Berberich J., Nage-Steger L., Epple M., Meyer-Zaika W., Horn A., Sticht H., Sinha S., Bitan G., Schrader T.:
Rational design of ?-sheet ligands against A?42-induced toxicity
In: Journal of the American Chemical Society 133 (2011), S. 4348-58
ISSN: 0002-7863
DOI: 10.1021/ja107675n - Kaßler K., Meier J., Eichler J., Sticht H.:
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides
In: Advances in Bioinformatics 2011 (2011), S. 736593
ISSN: 1687-8027
DOI: 10.1155/2011/736593 - Mandery K., Sticht H., Bujok K., Schmidt I., Fahrmayr C., Balk B., Fromm M., Gläser H.:
Functional and Structural Relevance of Conserved Positively Charged Lysine Residues in Organic Anion Transporting Polypeptide 1B3
In: Molecular Pharmacology 80 (2011), S. 400-6
ISSN: 0026-895X
DOI: 10.1124/mol.111.071282 - Meiselbach H., Sticht H.:
Effect of the SH3-SH2 domain linker sequence on the structure of Hck kinase
In: Journal of Molecular Modeling 17 (2011), S. 1927-34
ISSN: 1610-2940
DOI: 10.1007/s00894-010-0897-z - Pötzsch S., Spindler N., Wiegers AK., Fisch T., Ruecker P., Sticht H., Grieb N., Baroti T., Weisel F., Stamminger T., Martin-Parras L., Mach M., Winkler T.:
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies
In: PLoS Pathogens 7 (2011), Art.Nr.: e1002172
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1002172 - Rotthier A., Penno A., Rautenstrauss B., Auer-Grumbach M., Stettner GM., Asselbergh B., Van Hoof K., Sticht H., Levy N., Timmerman V., Hornemann T., Janssens K.:
Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I
In: Human Mutation 32 (2011), S. E2211-25
ISSN: 1059-7794
DOI: 10.1002/humu.21481 - Ruecker P., Horn A., Meiselbach H., Sticht H.:
A comparative study of HIV-1 and HTLV-I protease structure and dynamics reveals a conserved residue interaction network
In: Journal of Molecular Modeling 17 (2011), S. 2693-705
ISSN: 1610-2940
DOI: 10.1007/s00894-011-0971-1 - Schulze C., Sticht H., Meyerhoff P., Dietrich P.:
Differential contribution of EF-hands to the Ca²?-dependent activation in the plant two-pore channel TPC1
In: Plant Journal 68 (2011), S. 424-32
ISSN: 0960-7412
DOI: 10.1111/j.1365-313X.2011.04697.x - Seebahn A., Dinkel H., Mohrlüder J., Hartmann R., Vogel N., Becker CM., Sticht H., Enz R.:
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors.
In: Febs Letters (2011), S. 511-516
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.12.042 - Templin C., Ghadri JR., Rougier JS., Baumer A., Kaplan V., Albesa M., Sticht H., Rauch A., Puleo C., Hu D., Barajas-Martinez H., Antzelevitch C., Luescher TF., Abriel H., Duru F.:
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)
In: European Heart Journal 32 (2011), S. 1077-88
ISSN: 0195-668X
DOI: 10.1093/eurheartj/ehr076
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A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition
In: The Journal of Physiology 588 (2010), S. 1211-1225
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2009.180224
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DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR
In: Bmc Molecular Biology 10 (2009), S. 73
ISSN: 1471-2199
DOI: 10.1186/1471-2199-10-73
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PNUTS forms a trimeric protein complex with GABAC receptors and protein phosphatase 1.
In: Molecular and Cellular Neuroscience (2008), S. 808-819
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2008.01.004
- Cheusova T., Khan MA., Schubert S., Gavin AC., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner HR., Hashemolhosseini S.:
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.
In: Genes & Development (2006), S. 1800-1816
ISSN: 0890-9369
DOI: 10.1101/gad.375206 - Homeyer N., Horn A., Lanig H., Sticht H.:
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine.
In: Journal of Molecular Modeling 12 (2006), S. 281-9
ISSN: 0948-5023
DOI: 10.1007/s00894-005-0028-4 - Meiselbach H., Sticht H., Enz R.:
Structural analysis of the protein phosphatase 1 docking motif: Molecular description of the binding specificity identifies new ligands.
In: Chemistry & Biology (2006), S. 49-59
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2005.10.009
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Group I metabotropic glutamate receptors bind to protein phosphatase 1C: Mapping and modeling of interacting sequences.
In: Journal of Biological Chemistry (2003), S. 50682-50690
ISSN: 0021-9258
DOI: 10.1074/jbc.M305764200