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Forschung

Publikationen

Publikationen AG Sticht

2016

Breitinger U, Sticht H, Breitinger HG
Modulation of Recombinant Human ?1 Glycine Receptors by Mono- and Disaccharides: A Kinetic Study.
ACS Chem Neurosci. 2016;7(8): 1077-87

Breuss MW, Sultan T, James KN, Rosti RO, Scott E, Musaev D, Furia B, Reis A, Sticht H, Al-Owain M, Alkuraya FS, Reuter MS, Abou Jamra R, Trotta CR, Gleeson JG
Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly.
Am J Hum Genet. 2016;99(1): 228-35

Hutterer C, Hamilton S, Steingruber M, Zeitträger I, Bahsi H, Thuma N, Naing Z, Örfi Z, Örfi L, Socher E, Sticht H, Rawlinson W, Chou S, Haupt VJ, Marschall M
The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors.
Antiviral Res. 2016;134: 130-143

Gruetz M, Sticht H, Glaeser H, Fromm MF, König J
Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1).
Biochim Biophys Acta. 2016;1858(11): 2894-2902

Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.
BMC Microbiol. 2016;16(1): 201

Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C
Amyloid-? dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Brain. 2016;139(Pt 2): 509-25

Jamali V, Ahmadzadeh A, Jardin C, Sticht H, Schober R
Channel Estimation for Diffusive Molecular Communications
IEEE TRANSACTIONS ON COMMUNICATIONS. 2016;64(10): 4238-4252

Oecal S, Socher E, Uthoff M, Ernst C, Zaucke F, Sticht H, Baumann U, Gebauer JM
The pH-dependent Client Release from the Collagen-specific Chaperone HSP47 Is Triggered by a Tandem Histidine Pair.
J Biol Chem. 2016;291(24): 12612-26

Stump JD, Sticht H
Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states.
J Biomol Struct Dyn. 2016;34(5): 1029-41

Abela L, Simmons L, Steindl K, Schmitt B, Mastrangelo M, Joset P, Papuc M, Sticht H, Baumer A, Crowther LM, Mathis D, Rauch A, Plecko B
N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics.
J Inherit Metab Dis. 2016;39(1): 131-7

Socher E, Sticht H
Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations.
J Phys Chem B Condens Matter Mater Surf Interfaces
Biophys. 2016;120(46): 11845-11855

Mauri L, Uebe S, Sticht H, Vossmerbaeumer U, Weisschuh N, Manfredini E, Maselli E, Patrosso M, Weinreb RN, Penco S, Reis A, Pasutto F
Expanding the clinical spectrum of COL1A1 mutations in different forms of glaucoma.
Orphanet J Rare Dis. 2016;11(1): 108

Buchert R, Nesbitt AI, Tawamie H, Krantz ID, Medne L, Helbig I, Matalon DR, Reis A, Santani A, Sticht H, Abou Jamra R
SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss.
Orphanet J Rare Dis. 2016;11(1): 130

Milbradt J, Hutterer C, Bahsi H, Wagner S, Sonntag E, Horn AH, Kaufer BB, Mori Y, Sticht H, Fossen T, Marschall M
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.
PLoS Pathog. 2016;12(8): e1005825

Socher E, Sticht H
Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins.
Sci Rep. 2016;6: 22523

Steingruber M, Kraut A, Socher E, Sticht H, Reichel A, Stamminger T, Amin B, Coute Y, Hutterer C, Marschall M
Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins
Viruses. 2016;8(8): 219

2015

Ilyaskin A, Haerteis S, Sticht H, Korbmacher C, Diakov A
Bile acids activate the human epithelial sodium channel probably by interacting with its degenerin site
Acta Physiol Scand. 2015;213 699: 41-41

Stein MF, Blume K, Heilingloh CS, Kummer M, Biesinger B, Sticht H, Steinkasserer A
CD83 and GRASP55 interact in human dendritic cells.
Biochem Biophys Res Commun. 2015;459(1): 42-8

Popp B, Støve SI, Endele S, Myklebust LM, Hoyer J, Sticht H, Azzarello-Burri S, Rauch A, Arnesen T, Reis A
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females.
Eur J Hum Genet. 2015;23(5): 602-9

Groß A, Hashimoto C, Sticht H, Eichler J
Synthetic Peptides as Protein Mimics.
Front Bioeng Biotechnol. 2015;3: 211

Atak S, Langlhofer G, Schaefer N, Kessler D, Meiselbach H, Delto C, Schindelin H, Villmann C
Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia.
Front Mol Neurosci. 2015;8: 79

Pasutto F, Mauri L, Popp B, Sticht H, Ekici A, Piozzi E, Bonfante A, Penco S, Schlötzer-Schrehardt U, Reis A
Whole exome sequencing reveals a novel de novo FOXC1 mutation in a patient with unrecognized Axenfeld-Rieger syndrome and glaucoma.
Gene. 2015;568(1): 76-80

Ahmed I, Buchert R, Zhou M, Jiao X, Mittal K, Sheikh TI, Scheller U, Vasli N, Rafiq MA, Brohi MQ, Mikhailov A, Ayaz M, Bhatti A, Sticht H, Nasr T, Carter MT, Uebe S, Reis A, Ayub M, John P, Kiledjian M, Vincent JB, Jamra RA
Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.
Hum Mol Genet. 2015;24(11): 3172-80

Zahnleiter D, Hauer NN, Kessler K, Uebe S, Sugano Y, Neuhauss SC, Giessl A, Ekici AB, Blessing H, Sticht H, Dörr HG, Reis A, Thiel CT
MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation.
Hum Mutat. 2015;36(1): 87-97

Riecken LB, Tawamie H, Dornblut C, Buchert R, Ismayel A, Schulz A, Schumacher J, Sticht H, Pohl KJ, Cui Y, Reis A, Morrison H, Abou Jamra R
Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability.
Hum Mutat. 2015;36(2): 270-8

Walzer SA, Egerer-Sieber C, Sticht H, Sevvana M, Hohl K, Milbradt J, Muller YA, Marschall M
Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions.
J Biol Chem. 2015;290(46): 27452-8

Mössner R, Frambach Y, Wilsmann-Theis D, Löhr S, Jacobi A, Weyergraf A, Müller M, Philipp S, Renner R, Traupe H, Burkhardt H, Kingo K, Kõks S, Uebe S, Sticherling M, Sticht H, Oji V, Hüffmeier U
Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European Patients.
J Invest Dermatol. 2015;135(10): 2538-41

Jardin C, Horn AH, Sticht H
Binding properties of SUMO-interacting motifs (SIMs) in yeast.
J Mol Model (Online). 2015;21(3): 50

Schaefer N, Kluck CJ, Price KL, Meiselbach H, Vornberger N, Schwarzinger S, Hartmann S, Langlhofer G, Schulz S, Schlegel N, Brockmann K, Lynch B, Becker CM, Lummis SC, Villmann C
Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia.
J Neurosci. 2015;35(1): 422-37

Wiegers AK, Sticht H, Winkler TH, Britt WJ, Mach M
Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus.
J Virol. 2015;89(1): 361-72

Scherer M, Otto V, Stump JD, Klingl S, Müller R, Reuter N, Muller YA, Sticht H, Stamminger T
Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses.
J Virol. 2015;90(3): 1190-205

Giarrana ML, Joset P, Sticht H, Robb S, Steindl K, Rauch A, Klein A
A severe congenital myasthenic syndrome with „dropped head“ caused by novel MUSK mutations.
Muscle Nerve. 2015;52(4): 668-73

Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H
Responsiveness of B cells is regulated by the hinge region of IgD.
Nat Immunol. 2015;16(5): 534-43

Langlhofer G, Janzen D, Meiselbach H, Villmann C
Length of the TM3-4 loop of the glycine receptor modulates receptor desensitization.
Neurosci Lett. 2015;600: 176-81

Zhang XS, Tegtmeyer N, Traube L, Jindal S, Perez-Perez G, Sticht H, Backert S, Blaser MJ
A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.
PLoS Pathog. 2015;11(2): e1004621

Kessler K, Wunderlich I, Uebe S, Falk NS, Gießl A, Brandstätter JH, Popp B, Klinger P, Ekici AB, Sticht H, Dörr HG, Reis A, Roepman R, Seemanová E, Thiel CT
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Sci Rep. 2015;5: 11649

Steingruber M, Socher E, Hutterer C, Webel R, Bergbrede T, Lenac T, Sticht H, Marschall M
The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.
Viruses. 2015;7(8): 4582-601

2014

Socher E, Sticht H, Horn AH
The conformational stability of nonfibrillar amyloid-? peptide oligomers critically depends on the C-terminal peptide length.
ACS Chem Neurosci. 2014;5(3): 161-7

Buchert R, Tawamie H, Smith C, Uebe S, Innes AM, Al Hallak B, Ekici AB, Sticht H, Schwarze B, Lamont RE, Parboosingh JS, Bernier FP, Abou Jamra R
A Peroxisomal Disorder of Severe Intellectual Disability, Epilepsy, and Cataracts Due to Fatty Acyl-CoA Reductase 1 Deficiency.
Am J Hum Genet. 2014;95(5): 602-10

Reuter MiriamS, Musante Luciana, Hu Hao, Diederich Stefan, Sticht Heinrich, Ekici ArifB, Uebe Steffen, Wienker ThomasF, Bartsch Oliver, Zechner Ulrich, Oppitz Cornelia, Keleman Krystyna, Abou Jamra Rami, Najmabadi Hossein, Schweiger Susann, Reis Andre, Kahrizi Kimia
NDST1 Missense Mutations in Autosomal Recessive Intellectual Disability
Am J Med Genet A. 2014;164A(11): 2753-2763

Jochmann R, Holz P, Sticht H, Stürzl M
Validation of the reliability of computational O-GlcNAc prediction.
BBA – PROTEINS PROTEOM. 2014;1844(2): 416-21

Lüneburg N, Lieb W, Zeller T, Chen MH, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT, Fornage M, König IR, Loley C, Ojeda FM, Schillert A, Wang TJ, Sticht H, Kittel A, König J, Benjamin EJ, Sullivan LM, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann HE, Wild PS, Schunkert H, Psaty BM, Wiggins KL, Heckbert SR, Smith N, Lackner K, Lunetta KL, Blankenberg S, Erdmann J, Munzel T, Grant PJ, Vasan RS, Böger RH
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
Circ Cardiovasc Genet. 2014;7(6): 864-72

Basel-Vanagaite L, Yilmaz R, Tang S, Reuter MS, Rahner N, Grange DK, Mortenson M, Koty P, Feenstra H, Farwell Gonzalez KD, Sticht H, Boddaert N, Désir J, Anyane-Yeboa K, Zweier C, Reis A, Kubisch C, Jewett T, Zeng W, Borck G
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations.
Hum Genet. 2014;133(7): 939-49

Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients‘ neurons.
Hum Mol Genet. 2014;23(10): 2527-41

Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, Sticht H, Breitinger HG, Becker CM, Villmann C
Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior.
J Biol Chem. 2014;289(42): 29135-47

Kassler K, Sticht H
Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity.
J Biomol Struct Dyn. 2014;32(1): 52-64

Benderska N, Ivanovska J, Rau TT, Schulze-Luehrmann J, Mohan S, Chakilam S, Gandesiri M, Ziesché E, Fischer T, Söder S, Agaimy A, Distel L, Sticht H, Mahadevan V, Schneider-Stock R
DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells.
J Cell Sci. 2014;127(24): 5273-87

Asadollahi R, Oneda B, Joset P, Azzarello-Burri S, Bartholdi D, Steindl K, Vincent M, Cobilanschi J, Sticht H, Baldinger R, Reissmann R, Sudholt I, Thiel CT, Ekici AB, Reis A, Bijlsma EK, Andrieux J, Dieux A, FitzPatrick D, Ritter S, Baumer A, Latal B, Plecko B, Jenni OG, Rauch A
The clinical significance of small copy number variants in neurodevelopmental disorders.
J Med Genet. 2014;51(10): 677-88

Horn AH
A consistent force field parameter set for zwitterionic amino acid residues.
J Mol Model (Online). 2014;20(11): 2478

Stump JD, Sticht H
Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms.
J Mol Model (Online). 2014;20(4): 2192

Milbradt J, Kraut A, Hutterer C, Sonntag E, Schmeiser C, Ferro M, Wagner S, Lenac T, Claus C, Pinkert S, Hamilton ST, Rawlinson WD, Sticht H, Couté Y, Marschall M
Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus.
Mol Cell Proteomics. 2014;13(8): 2132-46

Hackenberg A, Baumer A, Sticht H, Schmitt B, Kroell-Seger J, Wille D, Joset P, Papuc S, Rauch A, Plecko B
Infantile epileptic encephalopathy, transient choreoathetotic movements, and hypersomnia due to a De Novo missense mutation in the SCN2A gene.
Neuropediatrics. 2014;45(4): 261-4

Murakami Y, Tawamie H, Maeda Y, Büttner C, Buchert R, Radwan F, Schaffer S, Sticht H, Aigner M, Reis A, Kinoshita T, Jamra RA
Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy.
PLoS Genet. 2014;10(5): e1004320

Kittel A, Müller F, König J, Mieth M, Sticht H, Zolk O, Kralj A, Heinrich MR, Fromm MF, Maas R
Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and ?-aminoisobutyrate metabolism in healthy volunteers.
PLoS ONE. 2014;9(2): e88544

Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains.
PLoS ONE. 2014;9(5): e96488

Spindler N, Diestel U, Stump JD, Wiegers AK, Winkler TH, Sticht H, Mach M, Muller YA
Structural basis for the recognition of human cytomegalovirus glycoprotein B by a neutralizing human antibody.
PLoS Pathog. 2014;10(10): e1004377

Scherer M, Klingl S, Sevvana M, Otto V, Schilling EM, Stump JD, Müller R, Reuter N, Sticht H, Muller YA, Stamminger T
Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.
PLoS Pathog. 2014;10(11): e1004512

Mueller-Schiffmann Andreas, Herring Arne, Abdel-Hafiz Laila, Schaebel Sandra, Wedel Diana, van Stegen Bernd, Horn AnselmHC, Sticht Heinrich, Gottmann Kurt, Silva MariaAngel, Keyvani Kathy, Korth Carsten
Abeta dimers are sufficient to cause cognitive impairments in the absence of plaques
Prion. 2014;8 S: 46-46

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