Publikationen

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Kulosik L., Schanze I., Zacher P., Al-Awam BS., Srinivasan VM., Gowda VK., Krey I., Fuchs A., Goldenberg A., Saugier-Veber P., Hashemi-Gorji F., Yassaee VR., Zenker M., Sticht H., Jamra RA., Neuser S.:
Truncating Variants in KIF5C Cause a Milder Disorder Distinct From KIF5C-Associated Cortical Dysplasia
In: Pediatric Neurology 179 (2026), p. 37-44
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2026.03.004
Tillmanns J., Wangen C., Geiger P., Häge S., Lenac Roviš T., Arnold P., Sticht H., Marschall M.:
The phospho-dynamics of cytomegalovirus capsid interaction, with its protein kinase and nuclear egress complex, provide an antiviral targeting concept
In: Antiviral Research 246 (2026), Article No.: 106335
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2025.106335

Asadollahi R., Ahmad A., Boonsawat P., Shahanoor Hinzen J., Lohse M., Bouazza-Arostegui B., Sun S., Utesch T., Sommer JD., Ilic D., Padmanarayana M., Fischermanns K., Ranjan M., Boll M., Ka C., Piton A., Mattioli F., Isidor B., Õunap K., Reinson K., Wojcik MH., Marshall CR., Mercimek-Andrews S., Matsumoto N., Miyake N., Stephan BdO., Honjo RS., Bertola DR., Kim CA., Yusupov R., Mefford HC., Christodoulou J., Lee J., Heath O., Brown NJ., Baker N., Stark Z., Delatycki M., Lake NJ., Zeidler S., Zuurbier L., Maas SM., de Kruiff CC., Rajabi F., Rodan LH., Coury SA., Platzer K., Oppermann H., Abou Jamra R., Beblo S., Maxton C., Śmigiel R., Underhill H., Dubbs H., Rosen A., Helbig KL., Helbig I., Ruggiero SMK., Fitzgerald MP., Kraemer D., Prada CE., Tenney J., Jayakar P., Redon S., Lefranc J., Uguen K., Race S., Efthymiou S., Maroofian R., Houlden H., Coppens S., Deconinck N., Ashokkumar B., Varalakshmi P., Gowda K VR., Eghbal F., Ghayoor Karimiani E., Heidari M., Neidhardt J., Owczarek-Lipska M., Korenke GC., Bamshad MJ., Campeau PM., Lehman A., Hendon LG., Wentzensen IM., Monaghan KG., Chen Y., Szuto A., Cohn RD., Au PYB., Hübner C., Boschann F., Manickam K., Koboldt DC., Rad A., Oprea G., Bachman KK., Seeley AH., Agolini E., Terracciano A., Carmelo P., Bupp C., Grysko B., Rein-Rothschild A., Ben Zeev B., Margolin A., Morrison J., Dagli A., Stolerman E., Louie RJ., Washington C., Stevens SJ., Heijligers M., Alkuraya FS., Lisfeld J., Neu A., Paoli Monteiro F., Santos Pessoa AL., Camelo-Filho AE., Kok F., Koeberl D., Riley K., Burglen L., Doummar D., Héron B., Mignot C., Keren B., Charles P., Nava C., Bernhard FP., Kühn AA., Thoms S., Morrie RD., Mekhoubad S., Green EM., Barmada SJ., Gitler AD., Jahn O., Rhee JS., Rosenmund C., Mitkovski M., Sticht H., Sun H., Le Gac G., Taschenberger H., Brose N., Dittman JS., Rauch A., Lipstein N.:
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
In: Nature Genetics 57 (2025), p. 2691-2704
ISSN: 1061-4036
DOI: 10.1038/s41588-025-02361-5
Berger E., Jauss RT., Ranells JD., Zonic E., von Wintzingerode L., Wilson A., Wagner J., Tuttle A., Thomas-Wilson A., Schulte B., Rabin R., Pappas J., Odgis JA., Muthaffar O., Mendez-Fadol A., Lynch M., Levy J., Lehalle D., Lake NJ., Krey I., Kozenko M., Knierim E., Jouret G., Jobanputra V., Isidor B., Hunt D., Hsieh TC., Holtz AM., Haack TB., Gold NB., Dunstheimer D., Donge M., Deb W., De La Rosa Poueriet KA., Danyel M., Christodoulou J., Chopra S., Callewaert B., Busche A., Brick L., Bigay BG., Arlt M., Anikar SS., Almohammal MN., Almanza D., Alhashem A., Bertoli-Avella A., Sticht H., Abou Jamra R.:
Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders
In: Genetics in Medicine (2025), Article No.: 101326
ISSN: 1098-3600
DOI: 10.1016/j.gim.2024.101326
Denysenko O., Horn A., Sticht H.:
Comparative Molecular Dynamics Study of 19 Bovine Antibodies with Ultralong CDR H3
In: Antibodies 14 (2025), Article No.: 70
ISSN: 2073-4468
DOI: 10.3390/antib14030070
Dhotre K., Schütz M., von Essen S., Fortelny L., Wangen C., Hahn F., Sticht H., Marschall M.:
Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and cis/trans isomerase Pin1 activity
In: Journal of General Virology 106 (2025), Article No.: 002160
ISSN: 0022-1317
DOI: 10.1099/jgv.0.002160
Linz B., Tegtmeyer N., Afroz S., Müsken M., Fox JG., Haesebrouck F., Kao MC., Sticht H., Backert S.:
Molecular characterization of four Helicobacter cetorum strains from dolphins compared to human Helicobacter pylori
In: Gut Microbes 17 (2025), Article No.: 2557982
ISSN: 1949-0976
DOI: 10.1080/19490976.2025.2557982
Scherer M., Brand L., Wolf L., tom Dieck T., Schäfer M., Lotter S., Burkovski A., Sticht H., Schober R., Castiglione K.:
Closed-Loop Long-Term Experimental Molecular Communication System
In: IEEE Transactions on Molecular, Biological and Multi-Scale Communications (2025)
ISSN: 2372-2061
DOI: 10.1109/TMBMC.2025.3615924
Simon F., Donhauser N., Kemeter L., Wittdorf F., Millen S., Sticht H., Thoma-Kreß A.:
HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission
In: PLoS Pathogens 21 (2025), Article No.: e1013570
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1013570
Tillmanns J., Battisti V., Kicuntod J., Hahn F., Obergfäll D., Geiger P., Wagner S., Buschmann H., Lesch B., Lischka P., Sticht H., Langer T., Marschall M.:
The conserved core nuclear egress complex (NEC) as an antiherpesviral drug target: Pharmacophore-based identification of NEC-specific inhibitors
In: Antiviral Research 239 (2025), Article No.: 106168
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2025.106168

Backert S., Tegtmeyer N., Horn A., Sticht H., Linz B.:
Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA
In: Cell Communication and Signaling 22 (2024), Article No.: 250
ISSN: 1478-811X
DOI: 10.1186/s12964-024-01635-5
Beierlein F., Horn A., Sticht H., Mokhir A., Imhof P.:
In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2
In: Biomolecules 14 (2024), Article No.: 153
ISSN: 2218-273X
DOI: 10.3390/biom14020153
Bergner CG., Breur M., Soto-Bernardini MC., Schäfer L., Lier J., Le Duc D., Bundalian L., Schubert S., Brenner D., Kreuz FR., Schulte B., Waisfisz Q., Bugiani M., Köhler W., Sticht H., Abou Jamra R., Van Der Knaap MS.:
Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy
In: Brain 147 (2024), p. 3562-3572
ISSN: 0006-8950
DOI: 10.1093/brain/awae085
Boonsawat P., Asadollahi R., Niedrist D., Steindl K., Begemann A., Joset P., Bhoj EJ., Li D., Zackai E., Vetro A., Barba C., Guerrini R., Whalen S., Keren B., Khan A., Jing D., Palomares Bralo M., Rikeros Orozco E., Hao Q., Schlott Kristiansen B., Zheng B., Donnelly D., Clowes V., Zweier M., Papik M., Siegel G., Sabatino V., Mocera M., Horn AH., Sticht H., Rauch A.:
Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/β-catenin signaling
In: American Journal of Human Genetics (2024)
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2024.07.016
Bosch E., Güse E., Kirchner P., Winterpacht A., Walther M., Alders M., Kerkhof J., Ekici AB., Sticht H., Sadikovic B., Reis A., Vasileiou G.:
The missing link: ARID1B non-truncating variants causing Coffin-Siris syndrome due to protein aggregation
In: Human genetics (2024)
ISSN: 0340-6717
DOI: 10.1007/s00439-024-02688-9
Brand L., Scherer M., tom Dieck T., Lotter S., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Closed Loop Molecular Communication Testbed: Setup, Interference Analysis, and Experimental Results
ICC 2024 - IEEE International Conference on Communications (Denver, CO, 9. Juni 2024 - 13. Juni 2024)
In: ICC 2024 - IEEE International Conference on Communications 2024
DOI: 10.1109/ICC51166.2024.10622231
Dehm V., Aberle T., Bladé LG., Aprato J., Weider M., Sticht H., Sock E., Wegner M.:
Molecular Analysis of the Differential Activity of Sox8 and Sox10 in Oligodendroglial Cells
In: International Journal of Molecular Sciences 25 (2024), Article No.: 13395
ISSN: 1422-0067
DOI: 10.3390/ijms252413395
Herbst C., Bothe V., Wegler M., Axer-Schaefer S., Audebert-Bellanger S., Gecz J., Cogne B., Feldman HB., Horn A., Hurst AC., Kelly MA., Kruer MC., Kurolap A., Laquerriere A., Li M., Mark PR., Morawski M., Nizon M., Pastinen T., Polster T., Saugier-Veber P., SeSong J., Sticht H., Stieler JT., Thifffault I., van Eyk CL., Marcorelles P., Vezain-Mouchard M., Abou Jamra R., Oppermann H.:
Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly
In: Human genetics 143 (2024), p. 455-469
ISSN: 0340-6717
DOI: 10.1007/s00439-024-02655-4
Kohrt S., Baheerathan A., Prokscha J., Zwosta A., Sticht H., Thoma-Kreß A.:
Identification of a Nuclear Localization Signal (NLS) in Human Transcription Elongation Factor ELL2
In: Cell Biochemistry and Function 42 (2024), Article No.: e70019
ISSN: 0263-6484
DOI: 10.1002/cbf.70019
Krumbholz M., Dolnik A., Sträng E., Ghete T., Skambraks S., Hutter S., Simonis A., Stegelmann F., Suttorp M., Horn A., Sticht H., Haferlach T., Bullinger L., Metzler M.:
A high proportion of germline variants in pediatric chronic myeloid leukemia
In: Molecular Cancer 23 (2024), Article No.: 206
ISSN: 1476-4598
DOI: 10.1186/s12943-024-02109-5
Linz B., Sticht H., Tegtmeyer N., Backert S.:
Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori
In: Trends in Microbiology 32 (2024), p. 847-857
ISSN: 0966-842X
DOI: 10.1016/j.tim.2024.02.001
Lux U., Meyer J., Jahn O., Davison A., Babai N., Gießl A., Wartenberg A., Sticht H., Brose N., Reim K., Brandstätter JH.:
Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex
In: Frontiers in Molecular Neuroscience 17 (2024), Article No.: 1308466
ISSN: 1662-5099
DOI: 10.3389/fnmol.2024.1308466
Marschall M., Schütz M., Wild M., Socher E., Wangen C., Dhotre K., Rawlinson WD., Sticht H.:
Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target
In: Cells 13 (2024), p. 1338
ISSN: 2073-4409
DOI: 10.3390/cells13161338
Reuter N., Kropff B., Chen X., Britt WJ., Sticht H., Mach M., Thomas M.:
The Autonomous Fusion Activity of Human Cytomegalovirus Glycoprotein B Is Regulated by Its Carboxy-Terminal Domain
In: Viruses 16 (2024), Article No.: 1482
ISSN: 1999-4915
DOI: 10.3390/v16091482
Schmid CM., Gregor A., Ruiz A., Manso Bazús C., Herman I., Ammouri F., Kotzaeridou U., McNiven V., Dupuis L., Steindl K., Begemann A., Rauch A., Suter AA., Isidor B., Mercier S., Nizon M., Cogné B., Deb W., Besnard T., Haack TB., Falb RJ., Müller AJ., Linden T., Haldeman-Englert CR., Ockeloen CW., Mattioli F., Reymond A., Ibrahim N., Naz S., Lacaze E., Bassetti JA., Hoefele J., Brunet T., Riedhammer KM., Elloumi HZ., Person R., Zou F., Kahle JJ., Cremer K., Schmidt A., Delrue MA., Almeida PM., Ramos F., Srivastava S., Quinlan A., Robertson S., Manka E., Kuechler A., Spranger S., Nowaczyk MJ., Elshafie RM., Alsharhan H., Hillman PR., Dunnington LA., Braakman HM., McKee S., Moresco A., Ignat AD., Newbury-Ecob R., Banneau G., Patat O., Kuerbitz J., Rzucidlo S., Sell SS., Gordon P., Schuhmann S., Reis A., Halleb Y., Stoeva R., Keren B., Al Masseri Z., Tümer Z., Hammer-Hansen S., Krüger Sølyst S., Steigerwald CG., Abreu NJ., Faust H., Müller-Nedebock A., Tran Mau-Them F., Sticht H., Zweier C.:
Further delineation of the SCAF4-associated neurodevelopmental disorder
In: European Journal of Human Genetics (2024), Article No.: 103
ISSN: 1018-4813
DOI: 10.1038/s41431-024-01760-2
Sharafutdinov I., Harrer A., Müsken M., Rottner K., Sticht H., Täger C., Naumann M., Tegtmeyer N., Backert S.:
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection
In: Cell Insight 3 (2024), Article No.: 100161
ISSN: 2772-8927
DOI: 10.1016/j.cellin.2024.100161
Yang F., Begemann A., Reichhart N., Haeckel A., Steindl K., Schellenberger E., Sturm RF., Barth M., Bassani S., Boonsawat P., Courtin T., Delobel B., Gunning B., Hardies K., Jennesson M., Legoff L., Linnankivi T., Prouteau C., Smal N., Spodenkiewicz M., Toelle SP., Van Gassen K., Van Paesschen W., Verbeek N., Ziegler A., Zweier M., Horn AH., Sticht H., Lerche H., Weckhuysen S., Strauß O., Rauch A.:
Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect
In: American Journal of Human Genetics 111 (2024), p. 1184-1205
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2024.04.014

Ahmad N., Fazeli W., Schließke S., Lesca G., Gokce-Samar Z., Mekbib KY., Jin SC., Burton J., Hoganson G., Petersen A., Gracie S., Granger L., Bartels E., Oppermann H., Kundishora A., Till M., Milleret-Pignot C., Dangerfield S., Viskochil D., Anderson KJ., Palculict TB., Schnur RE., Wentzensen IM., Tiller GE., Kahle KT., Kunz WS., Burkart S., Simons M., Sticht H., Abou Jamra R., Neuser S.:
De Novo Variants in RAB11B Cause Various Degrees of Global Developmental Delay and Intellectual Disability in Children
In: Pediatric Neurology 148 (2023), p. 164-171
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2023.08.023
Brand L., Scherer M., Lotter S., tom Dieck T., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Switchable Signaling Molecules for Media Modulation: Fundamentals, Applications, and Research Directions
In: IEEE Communications Magazine (2023), p. 1-7
ISSN: 0163-6804
DOI: 10.1109/MCOM.021.2300096
Breitinger U., Sedky CA., Sticht H., Breitinger HG.:
Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2
In: Virology Journal 20 (2023), Article No.: 142
ISSN: 1743-422X
DOI: 10.1186/s12985-023-02095-y
Conrad M., Horn A., Sticht H.:
Computational Analysis of Histamine Protonation Effects on H1R Binding
In: Molecules 28 (2023), Article No.: 3774
ISSN: 1420-3049
DOI: 10.3390/molecules28093774
Deubler M., Weißenborn L., Leukel S., Horn A., Eichler J., Sticht H.:
Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides
In: Biology 12 (2023), Article No.: 824
ISSN: 2079-7737
DOI: 10.3390/biology12060824
Langhammer F., Maroofian R., Badar R., Gregor A., Rochman M., Ratliff JB., Koopmans M., Herget T., Hempel M., Kortüm F., Heron D., Mignot C., Keren B., Brooks S., Botti C., Ben-Zeev B., Argilli E., Sherr EH., Gowda VK., Srinivasan VM., Bakhtiari S., Kruer MC., Salih MA., Kuechler A., Muller EA., Blocker K., Kuismin O., Park KL., Kochhar A., Brown K., Ramanathan S., Clark RD., Elgizouli M., Melikishvili G., Tabatadze N., Stark Z., Mirzaa GM., Ong J., Grasshoff U., Bevot A., von Wintzingerode L., Jamra RA., Hennig Y., Goldenberg P., Al Alam C., Charif M., Boulouiz R., Bellaoui M., Amrani R., Al Mutairi F., Tamim AM., Abdulwahab F., Alkuraya FS., Khouj EM., Alvi JR., Sultan T., Hashemi N., Karimiani EG., Ashrafzadeh F., Imannezhad S., Efthymiou S., Houlden H., Sticht H., Zweier C.:
Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders
In: Genetics in Medicine 25 (2023), Article No.: 100885
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100885
Reimann T., Müdsam C., Schachtler C., Ince S., Sticht H., Herrmann C., Stürzl M., Kost B.:
The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression
In: Nature Plants (2023)
ISSN: 2055-0278
DOI: 10.1038/s41477-023-01400-5
Schmid CM., Gregor A., Costain G., Morel CF., Massingham L., Schwab J., Quélin C., Faoucher M., Kaplan J., Procopio R., Saunders CJ., Cohen AS., Lemire G., Sacharow S., O'Donnell-Luria A., Segal RJ., Kianmahd Shamshoni J., Schweitzer D., Ebrahimi-Fakhari D., Monaghan K., Palculict TB., Napier MP., Tao A., Isidor B., Moradkhani K., Reis A., Sticht H., Chung WK., Zweier C.:
LHX2 haploinsufficiency causes a variable neurodevelopmental disorder
In: Genetics in Medicine 25 (2023), Article No.: 100839
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100839
Schütz M., Cordsmeier A., Wangen C., Horn A., Wyler E., Enßer A., Sticht H., Marschall M.:
The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells.
In: International Journal of Molecular Sciences 24 (2023)
ISSN: 1422-0067
DOI: 10.3390/ijms242417421
Schütz M., Wangen C., Sommerer M., Kögler M., Eickhoff J., Degenhart C., Klebl B., Naing Z., Egilmezer E., Hamilton ST., Rawlinson WD., Sticht H., Marschall M.:
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
In: Virus Research 335 (2023), Article No.: 199200
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2023.199200
Sharafutdinov I., Tegtmeyer-Backert N., Linz B., Rohde M., Vieth M., Tay ACY., Lamichhane B., Tuan VP., Fauzia KA., Sticht H., Yamaoka Y., Marshall BJ., Backert S.:
A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development
In: Cell Host & Microbe 31 (2023), p. 1345-1358.e6
ISSN: 1931-3128
DOI: 10.1016/j.chom.2023.06.016
Zanoni P., Steindl K., Sticht H., Oneda B., Joset P., Ivanovski I., Horn AH., Cabello EM., Laube J., Zweier M., Baumer A., Rauch A., Khan N.:
The genetic landscape and clinical implication of pediatric Moyamoya angiopathy in an international cohort
In: European Journal of Human Genetics (2023)
ISSN: 1018-4813
DOI: 10.1038/s41431-023-01320-0
Zarzecka U., Tegtmeyer N., Sticht H., Backert S.:
Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain
In: Medical Microbiology and Immunology (2023)
ISSN: 0300-8584
DOI: 10.1007/s00430-023-00766-9
von Wintzingerode L., Ben-Zeev B., Cesario C., Chan KM., Depienne C., Elpeleg O., Iascone M., Kelley WV., Nassogne MC., Niceta M., Pezzani L., Rahner N., Revencu N., Bekheirnia MR., Santiago-Sim T., Tartaglia M., Thompson ML., Trivisano M., Hentschel J., Sticht H., Abou Jamra R., Oppermann H.:
De novo variants in CNOT9 cause a neurodevelopmental disorder with or without epilepsy.
In: Genetics in Medicine 25 (2023)
ISSN: 1098-3600
DOI: 10.1016/j.gim.2023.100859

Aillaud I., Kaniyappan S., Chandupatla RR., Ramirez LM., Alkhashrom S., Eichler J., Horn A., Zweckstetter M., Mandelkow E., Sticht H., Funke SA.:
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
In: Alzheimer's Research and Therapy 14 (2022)
ISSN: 1758-9193
DOI: 10.1186/s13195-022-00959-z
Beudert M., Hahn L., Horn A., Hauptstein N., Sticht H., Meinel L., Luxenhofer R., Gutmann M., Luehmann T.:
Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels
In: Journal of Controlled Release 347 (2022), p. 115-126
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2022.04.028
Boonsawat P., Horn AHC., Steindl K., Baumer A., Joset P., Kraemer D., Bahr A., Ivanovski I., Cabello EM., Papik M., Zweier M., Oneda B., Sirleto P., Burkhardt T., Sticht H., Rauch A.:
Assessing clinical utility of preconception expanded carrier screening regarding residual risk for neurodevelopmental disorders
In: npj Genomic Medicine 7 (2022), Article No.: 45
ISSN: 2056-7944
DOI: 10.1038/s41525-022-00316-x
Brand L., Garkisch M., Lotter S., Schäfer M., Burkovski A., Sticht H., Castiglione K., Schober R.:
Media Modulation based Molecular Communication
In: IEEE Transactions on Communications (2022), p. 1-1
ISSN: 0090-6778
DOI: 10.1109/TCOMM.2022.3205949
Breitinger U., Farag NS., Sticht H., Breitinger HG.:
Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2
In: International Journal of Biochemistry and Cell Biology 145 (2022), Article No.: 106185
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2022.106185
Conrad M., Söldner C., Sticht H.:
Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H1 Receptor
In: International Journal of Molecular Sciences 23 (2022), Article No.: 1420
ISSN: 1422-0067
DOI: 10.3390/ijms23031420
Gerber CB., Fliedner A., Bartsch O., Berland S., Dewenter M., Haug M., Hayes I., Marin-Reina P., Mark PR., Martinez-Castellano F., Maystadt I., Karadurmus D., Steindl K., Wiesener A., Zweier M., Sticht H., Zweier C.:
Further characterization of Borjeson-Forssman-Lehmann syndrome in females due to de novo variants in PHF6
In: Clinical Genetics (2022)
ISSN: 0009-9163
DOI: 10.1111/cge.14173
Gregor A., Meerbrei T., Gerstner T., Toutain A., Lynch SA., Stals K., Maxton C., Lemke JR., Bernat JA., Bombei HM., Foulds N., Hunt D., Kuechler A., Beygo J., Stöbe P., Bouman A., Palomares-Bralo M., Santos-Simarro F., Garcia-Minaur S., Pacio-Miguez M., Popp B., Vasileiou G., Hebebrand M., Reis A., Schuhmann S., Krumbiegel M., Brown NJ., Sparber P., Melikyan L., Bessonova L., Cherevatova T., Sharkov A., Shcherbakova N., Dabir T., Kini U., Schwaibold EM., Haack TB., Bertoli M., Hoffjan S., Falb R., Shinawi M., Sticht H., Zweier C.:
De novo missense variants in FBXO11 alter its protein expression and subcellular localization
In: Human Molecular Genetics 31 (2022), p. 440-454
ISSN: 0964-6906
DOI: 10.1093/hmg/ddab265
Kerker I., Löhr S., Uebe S., Popp B., Vasileiou G., Bowes J., Kirchner P., Becker I., Giardina E., Korendowych E., Ekici AB., Ho P., Behrens F., Kohm M., Schett G., Rech J., Assmann G., Nimeh A., Padyukov L., Alenius GM., Mchugh NJ., Sticht H., Frey B., Burkhardt H., Barton A., Wiesmann da Silva Reis A., Hüffmeier U.:
Common RUNX3 missense variant contributes to psoriatic arthritis by modifying differentiation of CD8(+) T-cells
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2022
Kicuntod J., Häge S., Hahn F., Sticht H., Marschall M.:
The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors
In: Viruses 14 (2022), Article No.: 1021
ISSN: 1999-4915
DOI: 10.3390/v14051021
Kloeckner C., Murray JPF., Tavasoli M., Sticht H., Stoltenburg-Didinger G., Scholle LM., Bakhtiari S., Kruer MC., Darvish H., Firouzabadi SG., Pagnozzi A., Shukla A., Girisha KM., Narayanan DL., Kaur P., Maroofian R., Zaki MS., Noureldeen MM., Merkenschlager A., Gburek-Augustat J., Cali E., Banu S., Nahar K., Efthymiou S., Houlden H., Abou Jamra R., Williams J., Mcmaster CR., Platzer K.:
Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly
In: Brain (2022)
ISSN: 0006-8950
DOI: 10.1093/brain/awac074
Linck-Paulus L., Horn A., Matthies AO., Fischer S., Meister G., Sticht H., Kappelmann-Fenzl M., Boßerhoff AK.:
A novel splice variant of Argonaut 2 affects microRNA target genes and cell viability of melanoma cells
In: JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, HOBOKEN: 2022
Linck-Paulus L., Meißgeier T., Pieger K., Horn A., Matthies AO., Fischer S., Meister G., Sticht H., Kappelmann-Fenzl M., Boßerhoff AK.:
A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells
In: Cellular and Molecular Life Sciences 79 (2022), Article No.: 475
ISSN: 1420-682X
DOI: 10.1007/s00018-022-04496-8
Luppe J., Sticht H., Lecoquierre F., Goldenberg A., Gorman KM., Molloy B., Agolini E., Novelli A., Briuglia S., Kuismin O., Marcelis C., Vitobello A., Denomme-Pichon AS., Julia S., Lemke JR., Abou Jamra R., Platzer K.:
Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy
In: European Journal of Human Genetics (2022)
ISSN: 1018-4813
DOI: 10.1038/s41431-022-01269-6
Lösing J., Haege S., Schütz M., Wagner S., Wardin J., Sticht H., Marschall M.:
'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis
In: Cells 11 (2022)
ISSN: 2073-4409
DOI: 10.3390/cells11244030
Peter AS., Grüner E., Socher E., Fraedrich K., Richel E., Müller-Schmucker S., Cordsmeier A., Enßer A., Sticht H., Überla K.:
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
In: International Journal of Molecular Sciences 23 (2022)
ISSN: 1422-0067
DOI: 10.3390/ijms23158177
Platzer K., Sticht H., Bupp C., Ganapathi M., Pereira EM., Le Guyader G., Bilan F., Henderson LB., Lemke JR., Taschenberger H., Brose N., Abou Jamra R., Wojcik SM.:
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission
In: Annals of Neurology (2022)
ISSN: 0364-5134
DOI: 10.1002/ana.26485
Popp B., Bienvenu T., Giurgea I., Metreau J., Kraus C., Reis A., Fischer J., Bralo MP., Tenorio-Castano J., Lapunzina P., Almoguera B., Lopez-Grondona F., Sticht H., Zweier C.:
The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt-Hopkins syndrome
In: Clinical Genetics (2022)
ISSN: 0009-9163
DOI: 10.1111/cge.14206
Rahimi MJ., Urban N., Wegler M., Sticht H., Schaefer M., Popp B., Gaunitz F., Morleo M., Nigro V., Maitz S., Mancini GM., Ruivenkamp C., Suk EK., Bartolomaeus T., Merkenschlager A., Koboldt D., Bartholomew D., Stegmann AP., Sinnema M., Duynisveld I., Salvarinova R., Race S., de Vries BB., Trimouille A., Naudion S., Marom D., Hamiel U., Henig N., Demurger F., Rahner N., Bartels E., Hamm JA., Putnam AM., Person R., Abou Jamra R., Oppermann H.:
De novo variants in ATP2B1 lead to neurodevelopmental delay
In: American Journal of Human Genetics 109 (2022), p. 944-952
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2022.03.009
Rosenhahn E., O'Brien TJ., Zaki MS., Sorge I., Wieczorek D., Rostasy K., Vitobello A., Nambot S., Alkuraya FS., Hashem MO., Alhashem A., Tabarki B., Alamri AS., Al Safar AH., Bubshait DK., Alahmady NF., Gleeson JG., Abdel-Hamid MS., Lesko N., Ygberg S., Correia SP., Wredenberg A., Alavi S., Seyedhassani SM., Ebrahimi Nasab M., Hussien H., Omar TE., Harzallah I., Touraine R., Tajsharghi H., Morsy H., Houlden H., Shahrooei M., Ghavideldarestani M., Abdel-Salam GM., Torella A., Zanobio M., Terrone G., Brunetti-Pierri N., Omrani A., Hentschel J., Lemke JR., Sticht H., Abou Jamra R., Brown AE., Maroofian R., Platzer K.:
Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications
In: American Journal of Human Genetics 109 (2022), p. 1421-1435
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2022.06.008
Schweininger J., Kriegel M., Häge S., Conrad M., Alkhashrom S., Lösing J., Weiler S., Tillmanns J., Egerer-Sieber C., Decker A., Rovis TL., Eichler J., Sticht H., Marschall M., Muller Y.:
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity
In: Journal of Biological Chemistry 298 (2022), Article No.: 101625
ISSN: 0021-9258
DOI: 10.1016/j.jbc.2022.101625
Schütz M., Müller R., Socher E., Wangen C., Full F., Wyler E., Wong DD., Scherer M., Stamminger T., Chou S., Rawlinson WD., Hamilton ST., Sticht H., Marschall M.:
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
In: International Journal of Molecular Sciences 23 (2022), p. 11814
ISSN: 1422-0067
DOI: 10.3390/ijms231911814
Thuma N., Döhler D., Mielenz D., Sticht H., Radtke D., Reimann L., Warscheid B., Vöhringer D.:
A newly identified secreted larval antigen elicits basophil-dependent protective immunity against N. brasiliensis infection
In: Frontiers in Immunology 13 (2022), Article No.: 979491
ISSN: 1664-3224
DOI: 10.3389/fimmu.2022.979491
Vintschger E., Kraemer D., Joset P., Horn A., Rauch A., Sticht H., Bachmann-Gagescu R.:
Challenges for the implementation of next generation sequencing-based expanded carrier screening: Lessons learned from the ciliopathies
In: European Journal of Human Genetics (2022)
ISSN: 1018-4813
DOI: 10.1038/s41431-022-01267-8
Wegler M., Jia X., Alders M., Bouman A., Chen J., Duan X., Lauzon JL., Mathijssen IB., Sticht H., Syrbe S., Tan S., Guo H., Abou Jamra R.:
De novo variants in the PABP domain of PABPC1 lead to developmental delay
In: Genetics in Medicine (2022)
ISSN: 1098-3600
DOI: 10.1016/j.gim.2022.04.013
Weißenborn L., Richel E., Hueseman H., Welzer J., Beck S., Schäfer S., Sticht H., Überla K., Eichler J.:
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein
In: International Journal of Molecular Sciences 23 (2022)
ISSN: 1422-0067
DOI: 10.3390/ijms23116309

Appelhof B., Wagner M., Hoefele J., Heinze A., Roser T., Koch-Hogrebe M., Roosendaal SD., Dehghani M., Mehrjardi MYV., Torti E., Houlden H., Maroofian R., Rajabi F., Sticht H., Baas F., Wieczorek D., Abou Jamra R.:
Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1
In: European Journal of Human Genetics 29 (2021), p. 411-421
ISSN: 1018-4813
DOI: 10.1038/s41431-020-00749-x
Averdunk L., Sticht H., Surowy H., Luedecke HJ., Koch-Hogrebe M., Alsaif HS., Kahrizi K., Alzaidan H., Alawam BS., Tohary M., Kraus C., Endele S., Wadman E., Kaplan JD., Efthymiou S., Najmabadi H., Reis A., Alkuraya FS., Wieczorek D.:
Correction to: The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype (Journal of Molecular Medicine, (2021), 10.1007/s00109-021-02124-9)
In: Journal of Molecular Medicine (2021)
ISSN: 0946-2716
DOI: 10.1007/s00109-021-02153-4
Averdunk L., Sticht H., Surowy H., Luedecke HJ., Koch-Hogrebe M., Alsaif HS., Kahrizi K., Alzaidan H., Alawam BS., Tohary M., Kraus C., Endele S., Wadman E., Kaplan JD., Efthymiou S., Najmabadi H., Reis A., Alkuraya FS., Wieczorek D.:
The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype
In: Journal of Molecular Medicine (2021)
ISSN: 0946-2716
DOI: 10.1007/s00109-021-02124-9
Bachert W., Klotz L., Sticht H., Enz R.:
Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179
In: Neurochemistry International 149 (2021), Article No.: 105150
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2021.105150
Breitinger U., Ali NK., Sticht H., Breitinger HG.:
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
In: Frontiers in Microbiology 12 (2021), Article No.: 692423
ISSN: 1664-302X
DOI: 10.3389/fmicb.2021.692423
Breitinger U., Sticht H., Breitinger HG.:
Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols
In: Biological Chemistry (2021)
ISSN: 1431-6730
DOI: 10.1515/hsz-2020-0360
Durmus H., Mertoğlu E., Sticht H., Ceylaner S., Kulaksızoğlu IB., Hashemolhosseini S., Uçar EÖ., Parman Y.:
Episodic psychosis, ataxia, motor neuropathy with pyramidal signs (PAMP sydrome) caused by a novel mutation in ADPRHL2 (AHR3)
In: Neurological Sciences (2021)
ISSN: 1590-1874
DOI: 10.1007/s10072-021-05100-w
Höring C., Conrad M., Söldner C., Wang J., Sticht H., Strasser A., Miao Y.:
Specific engineered G protein coupling to histamine receptors revealed from cellular assay experiments and accelerated molecular dynamics simulations
In: International Journal of Molecular Sciences 22 (2021), Article No.: 10047
ISSN: 1422-0067
DOI: 10.3390/ijms221810047
Kicuntod J., Alkhashrom S., Häge S., Diewald B., Müller R., Hahn F., Lischka P., Sticht H., Eichler J., Marschall M.:
Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule
In: Viruses 13 (2021)
ISSN: 1999-4915
DOI: 10.3390/v13030462
Klöckner C., Sticht H., Zacher P., Popp B., Babcock HE., Bakker DP., Barwick K., Bonfert MV., Bönnemann CG., Brilstra EH., Chung WK., Clarke AJ., Devine P., Donkervoort S., Fraser JL., Friedman J., Gates A., Ghoumid J., Hobson E., Horvath G., Keller-Ramey J., Keren B., Kurian MA., Lee V., Leppig KA., Lundgren J., McDonald MT., McLaughlin HM., McTague A., Mefford HC., Mignot C., Mikati MA., Nava C., Raymond FL., Sampson JR., Sanchis-Juan A., Shashi V., Shieh JT., Shinawi M., Slavotinek A., Stödberg T., Stong N., Sullivan JA., Taylor AC., Toler TL., van den Boogaard MJ., van der Crabben SN., van Gassen KL., van Jaarsveld RH., Van Ziffle J., Wadley AF., Wagner M., Wigby K., Wortmann SB., Zarate YA., Møller RS., Lemke JR., Platzer K.:
Correction to: De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy (Genetics in Medicine, (2020), 10.1038/s41436-020-01020-w)
In: Genetics in Medicine (2021)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01090-w
Kohrt S., Strobel S., Mann M., Sticht H., Fleckenstein B., Thoma-Kreß A.:
Characterizing the interaction between the htlv-1 transactivator tax-1 with transcription elongation factor ell2 and its impact on viral transactivation
In: International Journal of Molecular Sciences 22 (2021), Article No.: 13597
ISSN: 1422-0067
DOI: 10.3390/ijms222413597
Konieczny A., Conrad M., Ertl FJ., Gleixner J., Gattor AO., Grätz L., Schmidt MF., Neu E., Horn A., Wifling D., Gmeiner P., Clark T., Sticht H., Keller M.:
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide y Y4Receptor Ligands Results in Picomolar Binding Constants
In: Journal of Medicinal Chemistry 64 (2021), p. 16746-16769
ISSN: 0022-2623
DOI: 10.1021/acs.jmedchem.1c01574
Malhis M., Kaniyappan S., Aillaud I., Chandupatla RR., Ramirez LM., Zweckstetter M., Horn A., Mandelkow E., Sticht H., Funke SA.:
Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display
In: ChemBioChem (2021)
ISSN: 1439-4227
DOI: 10.1002/cbic.202100287
Peter AS., Roth E., Schulz S., Fraedrich K., Steinmetz T., Damm D., Hauke M., Richel E., Müller-Schmucker S., Habenicht K., Eberlein V., Issmail L., Uhlig N., Dolles S., Grüner E., Peterhoff D., Ciesek S., Hoffmann M., Pöhlmann S., McKay PF., Shattock RJ., Wölfel R., Socher E., Wagner R., Eichler J., Sticht H., Schuh W., Neipel F., Enßer A., Mielenz D., Tenbusch M., Winkler T., Grunwald T., Überla K., Jäck HM.:
A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model
In: European Journal of Immunology (2021), Article No.: eji.202149374
ISSN: 0014-2980
DOI: 10.1002/eji.202149374
Regensburger D., Tenkerian C., Pürzer V., Schmid B., Wohlfahrt T., Stolzer I., Lopez Posadas R., Günther C., Waldner M., Becker C., Sticht H., Petter K., Flierl C., Gass T., Thoenissen T., Geppert CI., Britzen-Laurent N., Meniel VS., Ramming A., Stürzl M., Naschberger E.:
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease
In: Inflammatory Bowel Diseases (2021)
ISSN: 1078-0998
DOI: 10.1093/ibd/izaa346
Richard EM., Bakhtiari S., Marsh AP., Kaiyrzhanov R., Wagner M., Shetty S., Pagnozzi A., Nordlie SM., Guida BS., Cornejo P., Magee H., Liu J., Norton BY., Webster RI., Worgan L., Hakonarson H., Li J., Guo Y., Jain M., Blesson A., Rodan LH., Abbott MA., Comi A., Cohen JS., Alhaddad B., Meitinger T., Lenz D., Ziegler A., Kotzaeridou U., Brunet T., Chassevent A., Smith-Hicks C., Ekstein J., Weiden T., Hahn A., Zharkinbekova N., Turnpenny P., Tucci A., Yelton M., Horvath R., Gungor S., Hiz S., Oktay Y., Lochmuller H., Zollino M., Morleo M., Marangi G., Nigro V., Torella A., Pinelli M., Amenta S., Husain RA., Grossmann B., Rapp M., Steen C., Marquardt I., Grimmel M., Grasshoff U., Korenke GC., Owczarek-Lipska M., Neidhardt J., Radio FC., Mancini C., Claps Sepulveda DJ., McWalter K., Begtrup A., Crunk A., Guillen Sacoto MJ., Person R., Schnur RE., Mancardi MM., Kreuder F., Striano P., Zara F., Chung WK., Marks WA., van Eyk CL., Webber DL., Corbett MA., Harper K., Berry JG., MacLennan AH., Gecz J., Tartaglia M., Salpietro V., Christodoulou J., Kaslin J., Padilla-Lopez S., Bilguvar K., Munchau A., Ahmed ZM., Hufnagel RB., Fahey MC., Maroofian R., Houlden H., Sticht H., Mane SM., Rad A., Vona B., Jin SC., Haack TB., Makowski C., Hirsch Y., Riazuddin S., Kruer MC.:
Bi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss
In: American Journal of Human Genetics 108 (2021), p. 2006-2016
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2021.08.003
Schuhmann S., Koller H., Sticht H., Kraus C., Krumbiegel M., Uebe S., Ekici AB., Reis A., Thiel C.:
Clinical and molecular delineation of spondylocostal dysostosis type 3
In: Clinical Genetics (2021)
ISSN: 0009-9163
DOI: 10.1111/cge.13952
Schütz M., Steingruber M., Socher E., Müller R., Wagner S., Kögel M., Sticht H., Marschall M.:
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
In: Viruses 13 (2021), p. 1248
ISSN: 1999-4915
DOI: 10.3390/v13071248
Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation
In: Journal of Cellular Biochemistry (2021)
ISSN: 0730-2312
DOI: 10.1002/jcb.30142
Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
In: Biomedicines 9 (2021)
ISSN: 2227-9059
DOI: 10.3390/biomedicines9050525
URL: https://www.mdpi.com/2227-9059/9/5/525/xml
Söldner C., Sticht H., Horn A.:
Molecular Simulations and Alzheimer׳s Disease
In: Olaf Wolkenhauer (ed.): Systems Medicine: Integrative, qualitative, and computational approaches, Amsterdam: Elsevier, 2021, p. 54-70
ISBN: 9780128160787
DOI: 10.1016/B978-0-12-801238-3.11541-7
Thomas M., Kropff B., Schneider A., Winkler T., Görzer I., Sticht H., Britt WJ., Mach M., Reuter N.:
A novel strain-specific neutralizing epitope on glycoprotein H of human cytomegalovirus
In: Journal of Virology 95 (2021), Article No.: e00657-21
ISSN: 0022-538X
DOI: 10.1128/JVI.00657-21
Zanoni P., Steindl K., Sengupta D., Joset P., Bahr A., Sticht H., Lang-Muritano M., Van Ravenswaaij-Arts CMA., Shinawi M., Andrews M., Attie-Bitach T., Maystadt I., Belnap N., Benoit V., Delplancq G., De Vries BBA., Grotto S., Lacombe D., Larson A., Mourmans J., Ounap K., Petrilli G., Pfundt R., Ramsey K., Blok LS., Tsatsaris V., Vitobello A., Faivre L., Wheeler PG., Wevers MR., Wojcik M., Zweier M., Gozani O., Rauch A.:
Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype
In: Genetics in Medicine (2021)
ISSN: 1098-3600
DOI: 10.1038/s41436-021-01158-1

Abdelfattah F., Kariminejad A., Kahlert AK., Morrison PJ., Gumus E., Mathews KD., Darbro BW., Amor DJ., Walsh M., Sznajer Y., Weiß L., Weidensee S., Chitayat D., Shannon P., Bermejo-Sánchez E., Riaño-Galán I., Hayes I., Poke G., Rooryck C., Pennamen P., Khung-Savatovsky S., Toutain A., Vuillaume ML., Ghaderi-Sohi S., Kariminejad MH., Weinert S., Sticht H., Zenker M., Schanze D.:
Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders
In: Human Mutation (2020)
ISSN: 1059-7794
DOI: 10.1002/humu.24067
Begemann A., Sticht H., Begtrup A., Vitobello A., Faivre L., Banka S., Alhaddad B., Asadollahi R., Becker J., Bierhals T., Brown KE., Bruel AL., Brunet T., Carneiro M., Cremer K., Day R., Denommé-Pichon AS., Dyment DA., Engels H., Fisher R., Goh ES., Hajianpour MJ., Haertel LRM., Hauer N., Hempel M., Herget T., Johannsen J., Kraus C., Le Guyader G., Lesca G., Mau-Them FT., McDermott JH., McWalter K., Meyer P., Õunap K., Popp B., Reimand T., Riedhammer KM., Russo M., Sadleir LG., Saenz M., Schiff M., Schuler E., Syrbe S., Van der Ven AT., Verloes A., Willems M., Zweier C., Steindl K., Zweier M., Rauch A.:
New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics
In: Genetics in Medicine (2020)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01011-x
Begemann A., Sticht H., Mcwalter K., Vitobello A., Faivre L., Alhaddad B., Banka S., Becker J., Bierhals T., Brown K., Bruel A., Brunet T., Carneiro M., Cremer K., Day R., Denomme-Pichon A., Dyment DA., Engels H., Fisher R., Glassford M., Goh ES., Hajianpour M., Haertel LRM., Hauer N., Hempel M., Herget T., Kraus C., Le Guyader G., Lesca G., Mau-Them FT., Mcdermott JH., Meyer P., Ounap K., Popp B., Reimand T., Riedhammer KM., Russo M., Sadleir L., Schuler E., Siegel G., Syrbe S., Van Der Ven AT., Verloes A., Willems M., Zweier C., Steindl K., Zweier M., Rauch A.:
Expanding the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and functional proof of aberrant WRC-mediated actin dynamics
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020
Breitinger U., Weinländer K., Pechmann Y., Langlhofer G., Enz R., Becker CM., Sticht H., Kneussel M., Villmann C., Breitinger HG.:
A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin
In: Journal of Advanced Research (2020)
ISSN: 2090-1232
DOI: 10.1016/j.jare.2020.09.009
Conrad M., Söldner C., Miao Y., Sticht H.:
Agonist binding and g protein coupling in histamine h2 receptor: A molecular dynamics study
In: International Journal of Molecular Sciences 21 (2020), p. 1-18
ISSN: 1422-0067
DOI: 10.3390/ijms21186693
Donhauser N., Socher E., Millen S., Heym S., Sticht H., Thoma-Kreß A.:
Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8
In: PLoS Pathogens 16 (2020), Article No.: e1008879
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1008879
Durmus H., Sticht H., Ceylaner S., Hashemolhosseini S., Deymeer F.:
Rare slow channel congenital myasthenic syndromes without repetitive compound muscle action potential and dramatic response to low dose fluoxetine
In: Acta Neurologica Belgica (2020)
ISSN: 0300-9009
DOI: 10.1007/s13760-020-01505-0
Durmus H., Sticht H., Ceylaner S., Hashemolhosseini S., Parmn Y.:
EPISODIC PSYCHOSIS, ATAXIA, MOTOR NEUROPATHY CAUSED BY A NOVEL MUTATION IN ADPRHL2
Annual Meeting of the American-Academy-of-Neurology (Toronto, CANADA, 25. April 2020 - 1. Mai 2020)
In: NEUROLOGY, PHILADELPHIA: 2020
Fliedner A., Gregor A., Ferrazzi F., Ekici AB., Sticht H., Zweier C.:
Loss of PHF6 leads to aberrant development of human neuron-like cells
In: Scientific Reports 10 (2020), Article No.: 19030
ISSN: 2045-2322
DOI: 10.1038/s41598-020-75999-2
Frey S., Sticht H., Wilsmann-Theis D., Gerschütz A., Wolf K., Löhr S., Haskamp S., Frey B., Hahn M., Ekici AB., Uebe S., Thiel C., Reis A., Burkhardt H., Behrens F., Köhm M., Rech J., Schett G., Assmann G., Kingo K., Kõks S., Mössner R., Prinz JC., Oji V., Schulz P., Munoz LE., Kremer A., Wenzel J., Hüffmeier U.:
Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis
In: Journal of Investigative Dermatology (2020)
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.11.024
Grosche L., Knippertz I., König C., Royzman D., Wild A., Zinser E., Sticht H., Muller Y., Steinkasserer A., Lechmann M.:
The CD83 Molecule – An Important Immune Checkpoint
In: Frontiers in Immunology 11 (2020), Article No.: 721
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00721
Haskamp S., Bruns H., Hahn M., Hoffmann M., Gregor A., Löhr S., Hahn J., Ringer M., Flamann C., Frey B., Lesner A., Thiel C., Ekici AB., von Hörsten S., Aßmann G., Riepe C., Euler M., Schäkel K., Philipp S., Prinz JC., Mößner R., Kersting F., Sticherling M., Sefiani A., Lyahyai J., Sondermann W., Oji V., Schulz P., Wilsmann-Theis D., Sticht H., Schett G., Reis A., Uebe S., Frey S., Hüffmeier U., Schauer C.:
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
In: American Journal of Human Genetics 107 (2020), p. 527-538
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2020.07.001
Hussein RA., Ahmed M., Sticht H., Breitinger HG., Breitinger U.:
Fine-Tuning of Neuronal Ion Channels-Mapping of Residues Involved in Glucose Sensitivity of Recombinant Human Glycine Receptors
In: Acs Chemical Neuroscience (2020)
ISSN: 1948-7193
DOI: 10.1021/acschemneuro.0c00566
Hüffmeier U., Löhr S., Uebe S., Popp B., Bowes J., Kirchner P., Giardina E., Korendowych E., Ekici AB., Ho P., Behrens F., Koehm M., Schett G., Rech J., Assmann G., Nimeh A., Padyukov L., Alenius G., Mchugh NJ., Sticht H., Burkhardt H., Barton A., Reis A.:
Common RUNX3 missense variant contributes to psoriatic arthritis by affecting splicing and modifying signaling, activation and differentiation of T-cells
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020
Kloeckner C., Sticht H., Zacher P., Popp B., Babcock HE., Bakker DP., Barwick K., Bonfert M., Bonnemann CG., Brilstra EH., Chung WK., Clarke AJ., Devine P., Donkervoort S., Fraser JL., Friedman J., Gates A., Ghoumid J., Hobson E., Horvath G., Keller-Ramey J., Keren B., Kurian MA., Lee V., Leppig KA., Lundgren J., Mcdonald MT., Mctague A., Mefford HC., Mignot C., Mikati MA., Nava C., Raymond FL., Sampson JR., Sanchis-Juan A., Shashi V., Shieh JTC., Shinawi M., Slavotinek A., Stodberg T., Stong N., Sullivan JA., Taylor AC., Toler TL., Van Den Boogaard MJ., Van Der Crabben SN., Van Gassen KL., Van Jaarsveld RH., Van Ziffle J., Wadley AF., Wagner M., Wigby K., Wortmann SB., Zarate YA., Moller RS., Lemke JR., Platzer K.:
De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy
In: Genetics in Medicine (2020)
ISSN: 1098-3600
DOI: 10.1038/s41436-020-01020-w
Marschall M., Häge S., Conrad M., Alkhashrom S., Kicuntod J., Schweininger J., Kriegel M., Loesing J., Tillmanns J., Neipel F., Eichler J., Muller Y., Sticht H.:
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties
In: Viruses 12 (2020)
ISSN: 1999-4915
DOI: 10.3390/v12060683
Muller Y., Häge S., Alkhashrom S., Höllriegl T., Weigert S., Dolles S., Hof K., Walzer S., Egerer-Sieber C., Conrad M., Holst S., Lösing J., Sonntag E., Sticht H., Eichler J., Marschall M., Marschall M.:
High-resolution crystal structures of two prototypical β- And γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity
In: Journal of Biological Chemistry 295 (2020), p. 3189-3201
ISSN: 0021-9258
DOI: 10.1074/jbc.RA119.011546
Schuhmann S., Koller H., Sticht H., Kraus C., Krumbiegel M., Uebe S., Ekici AB., Reis A., Thiel CT.:
Further clinical and molecular delineation of spondylocostal dysostosis type 3
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020
Schütz M., Thomas M., Wangen C., Wagner S., Rauschert L., Errerd T., Kießling M., Sticht H., Milbradt J., Marschall M.:
The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus
In: Virus Research 285 (2020), Article No.: 198023
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2020.198023
Sharafutdinov I., Soltan Esmaeili D., Harrer A., Tegtmeyer N., Sticht H., Backert S.:
Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8
In: Frontiers in Cellular and Infection Microbiology 10 (2020)
ISSN: 2235-2988
DOI: 10.3389/fcimb.2020.590186
Söldner C., Socher E., Jamali V., Wicke W., Ahmadzadeh A., Breitinger HG., Burkovski A., Castiglione K., Schober R., Sticht H.:
A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems
In: IEEE Communications Surveys & Tutorials 22 (2020), p. 2765-2800
ISSN: 1553-877X
DOI: 10.1109/COMST.2020.3008819
Tegtmeyer N., Neddermann M., Lind J., Suneesh Kumar P., Sharafutdinov I., Gutiérrez-Escobar AJ., Brönstrup M., Tegge W., Hong M., Rohde M., Delahay RM., Sticht H., Backert S., Vieth M.:
Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori
In: Cell Reports 32 (2020), Article No.: 108159
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.108159
Thiel CT., Hauer N., Vogl C., Uebe S., Sticht H., Ekici AB., Kraus C., Dörr HG., Reis A.:
Mono-allelic deleterious variants in autosomal recessive skeletal dysplasia genes are strongly associated with idiopathic short stature
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020
Zanoni P., Steindl K., Sengupta D., Sticht H., Joset P., Baar A., Van Ravenswaaij-Arts CMA., Shinawi M., Maystadt I., Belnap N., Benoit V., De Vries BBA., Lacombe D., Larson A., Pfundt R., Ramsey K., Blok LS., Wheeler PG., Wevers MR., Gozani O., Rauch A.:
Loss-of-function truncating and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct neurodevelopmental phenotype
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2020

Begemann A., Acuna M., Zweier M., Sticht H., Steindl K., Besnard M., Hackenberg A., Abela L., Plecko B., Yamakawa K., Inoue Y., Baumer A., Joset P., Asadollahi R., Zeilhofer H., Rauch A.:
The functional consequences of SCN2A mutations determine the phenotype
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Begemann A., Acuna MA., Zweier M., Vincent M., Steindl K., Bachmann-Gagescu R., Hackenberg A., Abela L., Plecko B., Kroell-Seger J., Baumer A., Yamakawa K., Inoue Y., Asadollahi R., Sticht H., Zeilhofer HU., Rauch A.:
Further corroboration of distinct functional features in SCN2A variants causing intellectual disability or epileptic phenotypes
In: Molecular Medicine 25 (2019)
ISSN: 1076-1551
DOI: 10.1186/s10020-019-0073-6
Boonsawat P., Asadollahi R., Niedrist D., Joset P., Wisser J., Budka H., Bode PK., Sticht H., Steindl K., Rauch A.:
Whole-exome sequencing identifies novel causative variants and expands the phenotypic spectrum of PLK4-related primary microcephaly
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Boonsawat P., Joset P., Steindl K., Oneda B., Gogoll L., Azzarello-Burri S., Sheth F., Datar C., Verma I., Puri RD., Zollino M., Bachmann-Gagescu R., Niedrist D., Papik M., Figueiro-Silva J., Masood R., Zweier M., Kraemer D., Lincoln S., Rodan L., Passemard S., Drunat S., Verloes A., Horn A., Sticht H., Steinfeld R., Plecko B., Latal B., Jenni O., Asadollahi R., Rauch A.:
Elucidation of the phenotypic spectrum and genetic landscape in primary and secondary microcephaly
In: European Journal of Human Genetics (2019), p. 1401-1402
ISSN: 1018-4813
DOI: 10.1038/s41436-019-0464-7
Boonsawat P., Joset P., Steindl K., Oneda B., Gogoll L., Azzarello-Burri S., Sheth F., Datar C., Verma IC., Puri RD., Zollino M., Bachmann-Gagescu R., Niedrist D., Papik M., Figueiro-Silva J., Masood R., Zweier M., Kraemer D., Lincoln S., Rodan L., Passemard S., Drunat S., Verloes A., Horn A., Sticht H., Steinfeld R., Plecko B., Latal B., Jenni O., Asadollahi R., Rauch A.:
Elucidation of the phenotypic spectrum and genetic landscape in primary and secondary microcephaly
In: Genetics in Medicine 21 (2019), p. 2043-2058
ISSN: 1098-3600
DOI: 10.1038/s41436-019-0464-7
Harrer A., Buecker R., Böhm M., Zarzecka U., Tegtmeyer N., Sticht H., Schulzke JD., Backert S.:
Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
In: Gut Pathogens 11 (2019)
ISSN: 1757-4749
DOI: 10.1186/s13099-019-0283-z
Hauer N., Popp B., Taher L., Vogl C., Dhandapany PS., Büttner C., Uebe S., Sticht H., Ferrazzi F., Ekici AB., De Luca A., Klinger P., Kraus C., Zweier C., Wiesener A., Jamra RA., Kunstmann E., Rauch A., Wieczorek D., Jung AM., Rohrer TR., Zenker M., Dörr HG., Reis A., Thiel C.:
Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature
In: European journal of human genetics (2019)
ISSN: 1018-4813
DOI: 10.1038/s41431-019-0362-0
Hauer N., Vogl C., Popp B., Buettner C., Uebe S., Sticht H., Ekici AB., Klinger P., Kraus C., Krumbiegel M., Wiesener A., Dörr HG., Wiesmann da Silva Reis A., Thiel C.:
Exploring the phenotypical spectrum of BRD4 defects
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Horn S., Au M., Basel-Salmon L., Bayrak-Toydemir P., Chapin A., Cohen L., Elting MW., Graham JM., Gonzaga-Jauregui C., Konen O., Holzer M., Lemke J., Miller CE., Rey LK., Wolf NI., Weiss MM., Waisfisz Q., Mirzaa GM., Wieczorek D., Sticht H., Abou Jamra R.:
De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures
In: Brain 142 (2019), p. 3351-3359
ISSN: 0006-8950
DOI: 10.1093/brain/awz264
Hüffmeier U., Sticht H., Wenzel J., Wilsmann-Theis D., Wolff K., Löhr S., Frey B., Hahn M., Ekici AB., Uebe S., Thiel C., Wiesmann da Silva Reis A., Prinz J., Oji V., Schulz P., Kingo K., Koks S., Moessner R., Munoz LE., Kremer A., Frey S.:
Rare frameshift mutation in SERPINA3 contributes to generalized pustular psoriasis
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Iqbal Z., Tawamie H., Ba W., Reis A., Halak BA., Sticht H., Uebe S., Kasri NN., Riazuddin S., van Bokhoven H., Abou Jamra R.:
Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia
In: Genetics in Medicine (2019)
ISSN: 1098-3600
DOI: 10.1038/s41436-018-0415-8
Konrad E., Nardini N., Caliebe A., Nagel I., Young D., Horvath G., Santoro SL., Shuss C., Ziegler A., Bonneau D., Kempers M., Pfundt R., Legius E., Bouman A., Stuurman KE., Õunap K., Pajusalu S., Wojcik MH., Vasileiou G., Le Guyader G., Schnelle HM., Berland S., Zonneveld-Huijssoon E., Kersten S., Gupta A., Blackburn PR., Ellingson MS., Ferber MJ., Dhamija R., Klee EW., McEntagart M., Lichtenbelt KD., Kenney A., Vergano SA., Abou Jamra R., Platzer K., Ella Pierpont M., Khattar D., Hopkin RJ., Martin RJ., Jongmans MC., Chang VY., Martinez-Agosto JA., Kuismin O., Kurki MI., Pietiläinen O., Palotie A., Maarup TJ., Johnson DS., Venborg Pedersen K., Laulund LW., Lynch SA., Blyth M., Prescott K., Canham N., Ibitoye R., Brilstra EH., Shinawi M., Fassi E., Sticht H., Gregor A., Van Esch H., Zweier C.:
CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum
In: Genetics in Medicine 21 (2019), p. 2723-2733
ISSN: 1098-3600
DOI: 10.1038/s41436-019-0585-z
Krichel C., Möckel C., Schillinger O., Huesgen PF., Sticht H., Strodel B., Weiergräber OH., Willbold D., Neudecker P.:
Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
In: Scientific Reports 9 (2019), p. 14167-
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48155-8
Le Duc D., Giulivi C., Hiatt SM., Napoli E., Panoutsopoulos A., De Crescenzo A., Kotzaeridou U., Syrbe S., Anagnostou E., Azage M., Bend R., Begtrup A., Brown NJ., Buettner B., Cho MT., Cooper GM., Doering JH., Dubourg C., Everman DB., Hildebrand MS., Santos FJR., Kellam B., Keller-Ramey J., Lemke JR., Liu S., Niyazov D., Payne K., Person R., Quelin C., Schnur RE., Smith BT., Strober J., Walker S., Wallis M., Walsh L., Yang S., Yuen R., Ziegler A., Sticht H., Pride MC., Martinez-Cerdeno V., Silverman J., Scherer SW., Zarbalis KS., Abou Jamra R.:
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1093/brain/awz198
Le Duc D., Giulivi C., Hiatt SM., Napoli E., Panoutsopoulos A., Harlan De Crescenzo A., Kotzaeridou U., Syrbe S., Anagnostou E., Azage M., Bend R., Begtrup A., Brown NJ., Büttner B., Cho MT., Cooper GM., Doering JH., Dubourg C., Everman DB., Hildebrand MS., Santos FJR., Kellam B., Keller-Ramey J., Lemke JR., Liu S., Niyazov D., Payne K., Person R., Quélin C., Schnur RE., Smith BT., Strober J., Walker S., Wallis M., Walsh L., Yang S., Yuen RK., Ziegler A., Sticht H., Pride MC., Orosco L., Martínez-Cerdeño V., Silverman JL., Crawley JN., Scherer SW., Zarbalis KS., Jamra R.:
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size
In: Brain 142 (2019), p. 2617-2630
ISSN: 0006-8950
DOI: 10.1093/brain/awz198
Müller T., Gierke K., Joachimsthaler A., Sticht H., Izsvak Z., Hamra FK., Fejtová A., Ackermann F., Garner CC., Kremers J., Brandstätter JH., Regus-Leidig H.:
A Multiple Piccolino-RIBEYE Interaction Supports Plate-Shaped Synaptic Ribbons in Retinal Neurons
In: Journal of Neuroscience 39 (2019), p. 2606-2619
ISSN: 0270-6474
DOI: 10.1523/JNEUROSCI.2038-18.2019
Papuc S., Abela L., Steindl K., Begemann A., Simmons T., Schmitt B., Zweier M., Oneda B., Socher E., Crowther L., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor M., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and high-resolution copy number study
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Papuc SM., Abela L., Steindl K., Begemann A., Simmons TL., Schmitt B., Zweier M., Oneda B., Socher E., Crowther LM., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor MC., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study
In: European journal of human genetics 27 (2019), p. 408-421
ISSN: 1018-4813
DOI: 10.1038/s41431-018-0299-8
Platzer K., Sticht H., Edwards SL., Allen W., Angione KM., Bonati MT., Brasington C., Cho MT., Demmer LA., Falik-Zaccai T., Gamble CN., Hellenbroich Y., Iascone M., Kok F., Mahida S., Mandel H., Marquardt T., Mcwalter K., Panis B., Pepler A., Pinz H., Ramos L., Shinde DN., Smith-Hicks C., Stegmann APA., Stoebe P., Stumpel CTRM., Wilson C., Lemke JR., Di Donato N., Miller KG., Abou Jamra R.:
De novo variants in MAPK8IP3 cause intellectual disability with variable brain anomalies
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1016/j.ajhg.2018.12.008
Platzer K., Sticht H., Edwards SL., Allen W., Angione KM., Bonati MT., Brasington C., Cho MT., Demmer LA., Falik-Zaccai T., Gamble CN., Hellenbroich Y., Iascone M., Kok F., Mahida S., Mandel H., Marquardt T., Mcwalter K., Panis B., Pepler A., Pinz H., Ramos L., Shinde DN., Smith-Hicks C., Stegmann APA., Stoebe P., Stumpel CTRM., Wilson C., Lemke JR., Di Donato N., Miller KG., Jamra R.:
De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies
In: American Journal of Human Genetics 104 (2019), p. 203-212
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2018.12.008
Reuter MS., Jobling R., Chaturvedi RR., Manshaei R., Costain G., Heung T., Curtis M., Hosseini SM., Liston E., Lowther C., Oechslin E., Sticht H., Thiruvahindrapuram B., Van Mil S., Wald RM., Walker S., Marshall CR., Silversides CK., Scherer SW., Kim RH., Bassett AS.:
Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot
In: Genetics in Medicine 21 (2019), p. 1001-1007
ISSN: 1098-3600
DOI: 10.1038/s41436-018-0260-9
Steindl K., Kraemer D., Gogoll L., Zanoni P., Sticht H., Rauch A.:
Phenotype of the first patient harboring a de novo in-frame deletion in the LisH (LIS1 homology) domain of the WDR26 gene
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Steingruber M., Keller L., Socher E., Ferre S., Hesse AM., Coute Y., Hahn F., Buescher N., Plachter B., Sticht H., Marschall M.:
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
In: Journal of Biological Chemistry 294 (2019), p. 6188-6203
ISSN: 0021-9258
DOI: 10.1074/jbc.RA118.007049
Straub J., Konrad E., Grüner J., Toutain A., Bok LA., Cho MT., Crawford HP., Dubbs H., Douglas G., Jobling R., Johnson D., Krock B., Mikati MA., Nesbitt A., Nicolai J., Phillips M., Poduri A., Ortiz-Gonzales XR., Powis Z., Santani A., Smith L., Stegmann APA., Stumpel C., Vreeburg M., Study DDD., Fliedner A., Gregor A., Sticht H., Zweier C.:
De novo missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Suneesh Kumar P., Tegtmeyer N., Arnold IC., Lind J., Neddermann M., Falkeis-Veits C., Chattopadhyay S., Brönstrup M., Tegge W., Hong M., Sticht H., Müller A., Backert S., Vieth M.:
T4SS-dependent TLR5 activation by Helicobacter pylori infection
In: Nature Communications 10 (2019), Article No.: 5717
ISSN: 2041-1723
DOI: 10.1038/s41467-019-13506-6
Söldner C., Horn A., Sticht H.:
A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes
In: International Journal of Molecular Sciences 20 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20081970
Tenkerian C., Regensburger D., Langer V., Klingler A., Borau A., Sticht H., Ramming A., Wohlfahrt T., Schmid B., Meniel V., Grützmann R., Britzen-Laurent N., Schellerer V., Stürzl M., Naschberger E.:
SPARCL1 is an angiocrine inhibitor of tumorigenesis in colorectal carcinoma
AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology (Atlanta, GA, 29. März 2019 - 3. April 2019)
In: CANCER RESEARCH, PHILADELPHIA: 2019
DOI: 10.1158/1538-7445.AM2019-195
Thiel C., Hauer N., Vogl C., Ahmadian R., Dhandapany PS., Popp B., Buettner C., Ube S., Sticht H., Ferrazzi F., Ekici AB., De Luca A., Schoeller E., Schuhmann S., Heath KE., Hisado-Oliva A., Klinger P., Boppudi S., Kelkel J., Jung AM., Kraus C., Trautmann U., Wiesener A., Kutsche K., Rauch A., Wieczorek D., Rohrer T., Zenker M., Dörr HG., Wiesmann da Silva Reis A.:
Identification of novel candidate genes for idiopathic short stature using whole exome sequencing
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Zweier M., Begemann A., Mcwalter K., Cho MT., Abela L., Banka S., Behring B., Berger A., Brown CW., Carneiro M., Chen J., Cooper GM., Finnila CR., Sacoto MJG., Henderson A., Hüffmeier U., Joset P., Kerr B., Lesca G., Leszinski GS., Mcdermott JH., Meltzer MR., Monaghan KG., Mostafavi R., Ounap K., Plecko B., Powis Z., Purcarin G., Reimand T., Riedhammer KM., Schreiber JM., Sirsi D., Wierenga KJ., Wojcik MH., Papuc SM., Steindl K., Sticht H., Rauch A.:
Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures
52nd Conference of the European-Society-of-Human-Genetics (ESHG) (Gothenburg, SWEDEN, 15. Juni 2019 - 18. Juni 2019)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
DOI: 10.1038/s41431-018-0331-z
Zweier M., Begemann A., Mcwalter K., Cho MT., Abela L., Banka S., Behring B., Berger A., Brown CW., Carneiro M., Chen J., Cooper GM., Finnila CR., Sacoto MJG., Henderson A., Hüffmeier U., Joset P., Kerr B., Lesca G., Leszinski GS., Mcdermott JH., Meltzer MR., Monaghan KG., Mostafavi R., Ounap K., Plecko B., Powis Z., Purcarin G., Reimand T., Riedhammer KM., Schreiber JM., Sirsi D., Wierenga KJ., Wojcik MH., Papuc SM., Steindl K., Sticht H., Rauch A.:
Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures
In: European journal of human genetics 27 (2019), p. 747-759
ISSN: 1018-4813
DOI: 10.1038/s41431-018-0331-z

Albrecht N., Tegtmeyer N., Sticht H., Skorko-Glonek J., Backert S.:
Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation
In: Frontiers in Microbiology 9 (2018)
ISSN: 1664-302X
DOI: 10.3389/fmicb.2018.00642
Diewald B., Socher E., Söldner C., Sticht H.:
Conformational Dynamics of Herpesviral NEC Proteins in Different Oligomerization States
In: International Journal of Molecular Sciences 19 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19102908
Gregor A., Sadleir LG., Asadollahi R., Azzarello-Burri S., Battaglia A., Ousager LB., Boonsawat P., Bruel AL., Buchert R., Calpena E., Cogne B., Dallapiccola B., Distelmaier F., Elmslie F., Faivre L., Haack TB., Harrison V., Henderson A., Hunt D., Isidor B., Joset P., Kumada S., Lachmeijer AMA., Lees M., Lynch SA., Martinez F., Matsumoto N., Mcdougall C., Mefford HC., Miyake N., Myers CT., Moutton S., Nesbitt A., Novelli A., Orellana C., Rauch A., Rosello M., Saida K., Santani AB., Sarkar A., Scheffer IE., Shinawi M., Steindl K., Symonds JD., Zackai EH., Univ WCMGDDD., Reis A., Sticht H., Zweier C.:
De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder
In: American Journal of Human Genetics 103 (2018), p. 305-316
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2018.07.003
Hauer N., Popp B., Schoeller E., Schuhmann S., Heath KE., Hisado-Oliva A., Klinger P., Kraus C., Trautmann U., Zenker M., Zweier C., Wiesener A., Abou Jamra R., Kunstmann E., Wieczorek D., Uebe S., Ferrazzi F., Büttner C., Ekici AB., Rauch A., Sticht H., Dörr HG., Reis A., Thiel C.:
Clinical relevance of systematic phenotyping and exome sequencing in patients with short stature
In: Genetics in Medicine 20 (2018), p. 630-638
ISSN: 1098-3600
DOI: 10.1038/gim.2017.159
Ilyaskin A., Kirsch S., Böckmann R., Sticht H., Korbmacher C., Härteis S., Diakov A.:
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids.
In: Pflügers Archiv: European Journal of Physiology (2018)
ISSN: 0031-6768
DOI: 10.1007/s00424-018-2142-z
Leal A., Bogantes-Ledezma S., Ekici AB., Uebe S., Thiel C., Sticht H., Berghoff M., Berghoff C., Morera B., Meisterernst M., Reis A.:
The polynucleotide kinase 3'-phosphatase gene (PNKP) is involved in Charcot-Marie-Tooth disease (CMT2B2) previously related to MED25
In: Neurogenetics 19 (2018), p. 215-225
ISSN: 1364-6745
DOI: 10.1007/s10048-018-0555-7
Milbradt J., Sonntag E., Wagner S., Strojan H., Wangen C., Rovis TL., Lisnic B., Jonjic S., Sticht H., Britt WJ., Schlötzer-Schrehardt U., Marschall M.:
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
In: Viruses 10 (2018)
ISSN: 1999-4915
DOI: 10.3390/v10010035
Namakchian M., Kaßler K., Sticht H., Hensel M., Deiwick J.:
Structure-based functional analysis of effector protein SifA in living cells reveals motifs important for Salmonella intracellular proliferation
In: International Journal of Medical Microbiology 308 (2018), p. 84-96
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2017.09.004
Sandmann A., Sticht H.:
Probing the role of intercalating protein sidechains for kink formation in DNA
In: PLoS ONE 13 (2018)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0192605
Selch S., Chafai A., Sticht H., Birkenfeld AL., Fromm M., König J.:
Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-29547-8
Straub J., Konrad E., Grüner J., Toutain A., Bok LA., Cho MT., Crawford HP., Dubbs H., Douglas G., Jobling R., Johnson D., Krock B., Mikati MA., Nesbitt A., Nicolai J., Phillips M., Poduri A., Ortiz-Gonzalez XR., Powis Z., Santani A., Smith L., Stegmann APA., Stumpel C., Vreeburg M., Fliedner A., Gregor A., Sticht H., Zweier C.:
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila
In: American Journal of Human Genetics 102 (2018), p. 44-57
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2017.11.008
Söldner C., Horn A., Sticht H.:
Binding of histamine to the H1 receptora molecular dynamics study
In: Journal of Molecular Modeling 24 (2018)
ISSN: 1610-2940
DOI: 10.1007/s00894-018-3873-7
Söldner C., Horn A., Sticht H.:
Interaction of Glycolipids with the Macrophage Surface Receptor Mincle - a Systematic Molecular Dynamics Study
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-23624-8
Unterer B., Wiesmann V., Gunasekaran M., Sticht H., Tenkerian C., Behrens J., Leone M., Engel F., Britzen-Laurent N., Naschberger E., Wittenberg T., Stürzl M.:
IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD
In: Biochemical Journal 475 (2018), p. 2955-2967
ISSN: 0264-6021
DOI: 10.1042/BCJ20180123
Weerasekera D., Stengel F., Sticht H., De Mattos Guaraldi AL., Burkovski A., Azevedo Antunes de Oliveira C.:
The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems
In: BMC Microbiology 18 (2018), p. 106
ISSN: 1471-2180
DOI: 10.1186/s12866-018-1247-z

Asadollahi R., Zweier M., Gogoll L., Schiffmann R., Sticht H., Steindl K., Rauch A.:
Genotype-phenotype evaluation of MED13L defects in the light of a novel truncating and a recurrent missense mutation
In: European Journal of Medical Genetics 60 (2017), p. 451-464
ISSN: 1769-7212
DOI: 10.1016/j.ejmg.2017.06.004
Bootz A., Karbach A., Spindler J., Kropff B., Reuter N., Sticht H., Winkler T., Britt WJ., Mach M.:
Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus
In: PLoS Pathogens 13 (2017)
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1006601
Brechet A., Buchert R., Schwenk J., Boudkkazi S., Zolles G., Siquier-Pernet K., Schaber I., Bildl W., Saadi A., Bole-Feysot C., Nitschke P., Reis A., Sticht H., Al-Sanna'A N., Rolfs A., Kulik A., Schulte U., Colleaux L., Abou Jamra R., Fakler B.:
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
In: Nature Communications 8 (2017), p. 15910
ISSN: 2041-1723
DOI: 10.1038/ncomms15910
Hauer N., Sticht H., Boppudi S., Büttner C., Kraus C., Trautmann U., Zenker M., Zweier C., Wiesener A., Abou Jamra R., Wieczorek D., Kelkel J., Jung AM., Uebe S., Ekici AB., Rohrer T., Reis A., Dörr HG., Thiel C.:
Genetic screening confirms heterozygous mutations in ACAN as a major cause of idiopathic short stature
In: Scientific Reports 7 (2017), p. 12225
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12465-6
Heilingloh C., Klingl S., Egerer-Sieber C., Schmid B., Weiler S., Mühl-Zürbes P., Hofmann J., Stump J., Sticht H., Kummer M., Steinkasserer A., Muller Y.:
Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83
In: Journal of Molecular Biology 429 (2017), p. 1227-1243
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2017.03.009
König P., Buescher N., Steingruber M., Socher E., Sticht H., Tenzer S., Plachter B., Marschall M.:
Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions
In: Journal of General Virology 98 (2017), p. 2850-2863
ISSN: 0022-1317
DOI: 10.1099/jgv.0.000939
Lobo-Prada T., Sticht H., Bogantes-Ledezma S., Ekici AB., Uebe S., Reis A., Leal A.:
A Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica
In: JIMD reports 36 (2017), p. 59-66
ISSN: 2192-8304
DOI: 10.1007/8904_2016_40
Marschall M., Muller Y., Diewald B., Sticht H., Milbradt J.:
The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids
In: Reviews in Medical Virology 27 (2017), Article No.: e1934
ISSN: 1099-1654
DOI: 10.1002/rmv.1934
Mössner R., Wilsmann-Theis D., Oji V., Gkogkolou P., Löhr S., Schulz P., Körber A., Prinz JC., Renner R., Schäkel K., Vogelsang L., Peters KP., Philipp S., Reich K., Ständer H., Jacobi A., Weyergraf A., Kingo K., Kõks S., Gerdes S., Steinz K., Schill T., Griewank KG., Müller M., Frey S., Ebertsch L., Uebe S., Sticherling M., Sticht H., Hüffmeier U.:
The genetic basis for most patients with pustular skin disease remains elusive
In: British Journal of Dermatology (2017)
ISSN: 0007-0963
DOI: 10.1111/bjd.15867
Peters B., Stein J., Klingl S., Sander N., Sandmann A., Taccardi N., Sticht H., Gerlach R., Muller Y., Hensel M.:
Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
In: PLoS Pathogens 13 (2017), Article No.: e1006418
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1006418
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006418
Peters B., Stein J., Klingl S., Sander N., Sandmann A., Taccardi N., Sticht H., Gerlach RG., Muller Y., Hensel M.:
Structural and functional dissection reveals distinct roles of Ca2+-binding sites in the giant adhesin SiiE of Salmonella enterica
In: PLoS Pathogens 13 (2017), Article No.: e1006418
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1006418
Plecko B., Zweier M., Begemann A., Mathis D., Schmitt B., Striano P., Baethmann M., Vari MS., Beccaria F., Zara F., Crowther LM., Joset P., Sticht H., Papuc SM., Rauch A.:
Confirmation of mutations inPROSCas a novel cause of vitamin B 6 -dependent epilepsy
In: Journal of Medical Genetics 54 (2017), p. 809-814
ISSN: 0022-2593
DOI: 10.1136/jmedgenet-2017-104521
Pröschel M., Kraner M., Horn A., Schäfer L., Sonnewald U., Sticht H.:
Probing the potential of CnaB-type domains for the design of tag/catcher systems
In: PLoS ONE 12 (2017)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0179740
Redler S., Strom TM., Wieland T., Cremer K., Engels H., Distelmaier F., Schaper J., Kuchler A., Lemke JR., Jeschke S., Schreyer N., Sticht H., Koch M., Luedecke HJ., Wieczorek D.:
Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID
In: European journal of human genetics 25 (2017), p. 889-893
ISSN: 1018-4813
DOI: 10.1038/ejhg.2017.52
Reuter M., Tawamie H., Buchert R., Gebril OH., Froukh T., Thiel C., Uebe S., Ekici AB., Krumbiegel M., Zweier C., Hoyer J., Eberlein K., Bauer J., Scheller U., Strom TM., Hoffjan S., Abdelraouf ER., Meguid NA., Abboud A., Al Khateeb MA., Fakher M., Hamdan S., Ismael A., Muhammad S., Abdallah E., Sticht H., Wieczorek D., Reis A., Abou Jamra R.:
Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders
In: JAMA Psychiatry 74 (2017), p. 293-299
ISSN: 2168-622X
DOI: 10.1001/jamapsychiatry.2016.3798
Sighart R., Rech J., Hueber A., Blank N., Löhr S., Reis A., Sticht H., Hüffmeier U.:
Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes
In: Rheumatology International (2017)
ISSN: 0172-8172
DOI: 10.1007/s00296-017-3885-0
Söldner C., Sticht H., Horn A.:
Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry
In: PLoS ONE 12 (2017)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0186347
Tawamie H., Martianov I., Wohlfahrt N., Buchert R., Mengus G., Uebe S., Janiri L., Hirsch FW., Schumacher J., Ferrazzi F., Sticht H., Reis A., Davidson I., Colombo R., Abou Jamral R.:
Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly
In: American Journal of Human Genetics 100 (2017), p. 555-561
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2017.01.032

Abela L., Simmons L., Steindl K., Schmitt B., Mastrangelo M., Joset P., Papuc M., Sticht H., Baumer A., Crowther LM., Mathis D., Rauch A., Plecko B.:
N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics
In: Journal of Inherited Metabolic Disease 39 (2016), p. 131-7
ISSN: 0141-8955
DOI: 10.1007/s10545-015-9876-y
Breitinger U., Sticht H., Breitinger HG.:
Modulation of Recombinant Human ?1 Glycine Receptors by Mono- and Disaccharides: A Kinetic Study
In: Acs Chemical Neuroscience 7 (2016), p. 1077-87
ISSN: 1948-7193
DOI: 10.1021/acschemneuro.6b00044
Breuss MW., Sultan T., James KN., Rosti RO., Scott E., Musaev D., Furia B., Reis A., Sticht H., Al-Owain M., Alkuraya FS., Reuter M., Abou Jamra R., Trotta CR., Gleeson JG.:
Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly
In: American Journal of Human Genetics 99 (2016), p. 228-35
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2016.05.023
Buchert R., Nesbitt AI., Tawamie H., Krantz ID., Medne L., Helbig I., Matalon DR., Reis A., Santani A., Sticht H., Abou Jamra R.:
SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss
In: Orphanet Journal of Rare Diseases 11 (2016), p. 130
ISSN: 1750-1172
DOI: 10.1186/s13023-016-0509-9
Dammers C., Yolcu D., Kukuk L., Willbold D., Pickhardt M., Mandelkow E., Horn A., Sticht H., Malhis MN., Will N., Schuster J., Funke SA.:
Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease
In: PLoS ONE 11 (2016)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0167432
Gruetz M., Sticht H., Gläser H., Fromm M., König J.:
Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1)
In: BBA - Biochimica et Biophysica Acta 1858 (2016), p. 2894-2902
ISSN: 0006-3002
DOI: 10.1016/j.bbamem.2016.08.018
Hutterer C., Hamilton S., Steingruber M., Zeitträger I., Bahsi H., Thuma N., Naing Z., Oerfi Z., Oerfi L., Socher E., Sticht H., Rawlinson W., Chou S., Haupt VJ., Marschall M.:
The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors
In: Antiviral Research 134 (2016), p. 130-143
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2016.08.005
Jamali Kooshkghazi V., Ahmadzadeh A., Jardin C., Sticht H., Schober R.:
Channel Estimation for Diffusive Molecular Communications
In: IEEE Transactions on Communications 64 (2016), p. 4238 - 4252
ISSN: 0090-6778
DOI: 10.1109/TCOMM.2016.2601098
Jamali Kooshkghazi V., Ahmadzadeh A., Jardin C., Sticht H., Schober R.:
Channel estimation techniques for diffusion-based molecular communications
2016 IEEE International Conference on Communications (ICC) (Kuala Lumpur, 22. Mai 2016 - 27. Mai 2016)
DOI: 10.1109/ICC.2016.7511496
Lind J., Backert S., Hoffmann R., Eichler J., Yamaoka Y., Perez-Perez GI., Torres J., Sticht H., Tegtmeyer N.:
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains
In: BMC Microbiology 16 (2016), p. 201
ISSN: 1471-2180
DOI: 10.1186/s12866-016-0820-6
Ludwig J., Ulm N., Pröschel M., Sticht H., Sonnewald U., Eichler J.:
CHARACTERIZATION OF THE SPYTAG - SPY-CATCHER INTERACTION
In: Journal of Peptide Science 22 (2016), p. S66-S66
ISSN: 1075-2617
Mauri L., Uebe S., Sticht H., Vossmerbaeumer U., Weisschuh N., Manfredini E., Maselli E., Patrosso M., Weinreb RN., Penco S., Reis A., Pasutto F.:
Expanding the clinical spectrum of COL1A1 mutations in different forms of glaucoma
In: Orphanet Journal of Rare Diseases 11 (2016), p. 108
ISSN: 1750-1172
DOI: 10.1186/s13023-016-0495-y
Milbradt J., Hutterer C., Bahsi H., Wagner S., Sonntag E., Horn A., Kaufer BB., Mori Y., Sticht H., Fossen T., Marschall M.:
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress
In: PLoS Pathogens 12 (2016), p. e1005825
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1005825
Mueller-Schiffmann A., Herring A., Abdel-Hafiz L., Chepkova AN., Schaeble S., Wedel D., Horn A., Sticht H., Silva MADS., Gottmann K., Sergeeva OA., Huston JP., Keyvani K., Korth C.:
Amyloid-? dimers in the absence of plaque pathology impair learning and synaptic plasticity
In: Brain 139 (2016), p. 509-25
ISSN: 0006-8950
DOI: 10.1093/brain/awv355
Oecal S., Socher E., Uthoff M., Ernst C., Zaucke F., Sticht H., Baumann U., Gebauer JM.:
The pH-dependent client release from the collagen-specific chaperone HSP47 is triggered by a tandem histidine pair
In: Journal of Biological Chemistry 291 (2016), p. 12612-12626
ISSN: 0021-9258
DOI: 10.1074/jbc.M115.706069
Socher E., Sticht H.:
Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
In: Scientific Reports 6 (2016), Article No.: 22523
ISSN: 2045-2322
DOI: 10.1038/srep22523
URL: http://www.nature.com/articles/srep22523
Socher E., Sticht H.:
Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations
In: Journal of Physical Chemistry B 120 (2016), p. 11845-11855
ISSN: 1520-6106
DOI: 10.1021/acs.jpcb.6b06091
Steingruber M., Kraut A., Socher E., Sticht H., Reichel A., Stamminger T., Amin B., Coute Y., Hutterer C., Marschall M.:
Proteomic interaction patterns between human cyclins, the cyclin-dependent kinase ortholog pUL97 and additional cytomegalovirus proteins
In: Viruses 8 (2016), Article No.: 219
ISSN: 1999-4915
DOI: 10.3390/v8080219
Stump J., Sticht H.:
Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states
In: Journal of Biomolecular Structure & Dynamics 34 (2016), p. 1029-41
ISSN: 0739-1102
DOI: 10.1080/07391102.2015.1065204

Ahmed I., Buchert R., Zhou M., Jiao X., Mittal K., Sheikh TI., Scheller U., Vasli N., Rafiq MA., Brohi MQ., Mikhailov A., Ayaz M., Bhatti A., Sticht H., Nasr T., Carter MT., Uebe S., Reis A., Ayub M., John P., Kiledjian M., Vincent JB., Jamra RA.:
Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment
In: Human Molecular Genetics 24 (2015), p. 3172-80
ISSN: 0964-6906
DOI: 10.1093/hmg/ddv069
Giarrana ML., Joset P., Sticht H., Robb S., Steindl K., Rauch A., Klein A.:
A severe congenital myasthenic syndrome with "dropped head" caused by novel MUSK mutations
In: Muscle & Nerve 52 (2015), p. 668-73
ISSN: 0148-639X
DOI: 10.1002/mus.24687
Groß A., Hashimoto C., Sticht H., Eichler J.:
Synthetic Peptides as Protein Mimics
In: Frontiers in Bioengineering and Biotechnology 3 (2015), p. 211
ISSN: 2296-4185
DOI: 10.3389/fbioe.2015.00211
Jardin C., Horn A., Sticht H.:
Binding properties of SUMO-interacting motifs (SIMs) in yeast
In: Journal of Molecular Modeling 21 (2015), p. 50
ISSN: 1610-2940
DOI: 10.1007/s00894-015-2597-1
Keßler K., Wunderlich I., Uebe S., Falk N., Gießl A., Brandstätter JH., Popp B., Klinger P., Ekici AB., Sticht H., Dörr HG., Reis A., Roepman R., Seemanova E., Thiel C.:
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects
In: Scientific Reports 5 (2015), p. 11649
ISSN: 2045-2322
DOI: 10.1038/srep11649
Moessner R., Frambach Y., Wilsmann-Theis D., Loehr S., Jacobi A., Weyergraf A., Mueller M., Philipp S., Renner R., Traupe H., Burkhardt H., Kingo K., Koks S., Uebe S., Sticherling M., Sticht H., Oji V., Hüffmeier U.:
Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European Patients
In: Journal of Investigative Dermatology 135 (2015), p. 2538-41
ISSN: 0022-202X
DOI: 10.1038/jid.2015.186
Pasutto F., Mauri L., Popp B., Sticht H., Ekici AB., Piozzi E., Bonfante A., Penco S., Schlötzer-Schrehardt U., Reis A.:
Whole exome sequencing reveals a novel de novo FOXC1 mutation in a patient with unrecognized Axenfeld-Rieger syndrome and glaucoma
In: Gene 568 (2015), p. 76-80
ISSN: 0378-1119
DOI: 10.1016/j.gene.2015.05.015
Popp B., Stove SI., Endele S., Myklebust LM., Hoyer J., Sticht H., Azzarello-Burri S., Rauch A., Arnesen T., Reis A.:
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females
In: European journal of human genetics 23 (2015), p. 602-9
ISSN: 1018-4813
DOI: 10.1038/ejhg.2014.150
Riecken LB., Tawamie H., Dornblut C., Buchert R., Ismayel A., Schulz A., Schumacher J., Sticht H., Pohl KJ., Cui Y., Reis A., Morrison H., Abou Jamra R.:
Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability
In: Human Mutation 36 (2015), p. 270-8
ISSN: 1059-7794
DOI: 10.1002/humu.22737
Scherer M., Otto V., Stump J., Klingl S., Müller R., Reuter N., Muller Y., Sticht H., Stamminger T.:
Characterization of recombinant human cytomegaloviruses encoding IE1 mutants L174P and 1-382 reveals that viral targeting of PML bodies perturbs both intrinsic and innate immune responses
In: Journal of Virology 90 (2015), p. 1190-1205
ISSN: 0022-538X
DOI: 10.1128/JVI.01973-15
Stein MF., Blume K., Heilingloh C., Kummer M., Biesinger B., Sticht H., Steinkasserer A.:
CD83 and GRASP55 interact in human dendritic cells
In: Biochemical and Biophysical Research Communications 459 (2015), p. 42-8
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2015.02.057
Steingruber M., Socher E., Hutterer C., Webel R., Bergbrede T., Lenac T., Sticht H., Marschall M.:
The interaction between cyclin B1 and cytomegalovirus protein kinase pUL97 is determined by an active kinase domain
In: Viruses 7 (2015), p. 4582-4601
ISSN: 1999-4915
DOI: 10.3390/v7082834
Uebelhart R., Hug E., Bach MP., Wossning T., Duehren-Von Minden M., Horn A., Tsiantoulas D., Kometani K., Kurosaki T., Binder CJ., Sticht H., Nitschke L., Reth M., Jumaa H.:
Responsiveness of B cells is regulated by the hinge region of IgD
In: Nature Immunology 16 (2015), p. 534-43
ISSN: 1529-2908
DOI: 10.1038/ni.3141
Walzer S., Egerer-Sieber C., Sticht H., Sevvana M., Hohl K., Milbradt J., Muller Y., Marschall M.:
Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions
In: Journal of Biological Chemistry 290 (2015), p. 27452-27458
ISSN: 0021-9258
DOI: 10.1074/jbc.C115.686527
Wiegers AK., Sticht H., Winkler T., Britt WJ., Mach M.:
Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus
In: Journal of Virology 89 (2015), p. 361-72
ISSN: 0022-538X
DOI: 10.1128/JVI.02393-14
Zahnleiter D., Hauer N., Keßler K., Uebe S., Sugano Y., Neuhauss SCF., Gießl A., Ekici AB., Blessing H., Sticht H., Dörr HG., Reis A., Thiel C.:
MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation
In: Human Mutation 36 (2015), p. 87-97
ISSN: 1059-7794
DOI: 10.1002/humu.22711
Zhang XS., Tegtmeyer N., Traube L., Jindal S., Perez-Perez G., Sticht H., Backert S., Blaser MJ.:
A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions
In: PLoS Pathogens 11 (2015), p. e1004621
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1004621

Asadollahi R., Oneda B., Joset P., Azzarello-Burri S., Bartholdi D., Steindl K., Vincent M., Cobilanschi J., Sticht H., Baldinger R., Reissmann R., Sudholt I., Thiel C., Ekici AB., Reis A., Bijlsma EK., Andrieux J., Dieux A., Fitzpatrick D., Ritter S., Baumer A., Latal B., Plecko B., Jenni OG., Rauch A.:
The clinical significance of small copy number variants in neurodevelopmental disorders
In: Journal of Medical Genetics 51 (2014), p. 677-88
ISSN: 0022-2593
DOI: 10.1136/jmedgenet-2014-102588
Basel-Vanagaite L., Yilmaz R., Tang S., Reuter M., Rahner N., Grange DK., Mortenson M., Koty P., Feenstra H., Gonzalez KDF., Sticht H., Boddaert N., Desir J., Anyane-Yeboa K., Zweier C., Reis A., Kubisch C., Jewett T., Zeng W., Borck G.:
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations
In: Human genetics 133 (2014), p. 939-49
ISSN: 0340-6717
DOI: 10.1007/s00439-014-1436-2
Benderska N., Ivanovska J., Rau T., Schulze-Luehrmann J., Mohan S., Chakilam S., Gandesiri M., Ziesche E., Fischer T., Söder S., Agaimy A., Distel L., Sticht H., Mahadevan V., Schneider-Stock R.:
DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells
In: Journal of Cell Science 127 (2014), p. 5273-87
ISSN: 0021-9533
DOI: 10.1242/jcs.157024
Buchert R., Tawamie H., Smith C., Uebe S., Innes AM., Al Hallak B., Ekici AB., Sticht H., Schwarze B., Lamont RE., Parboosingh JS., Bernier FP., Abou Jamra R.:
A Peroxisomal Disorder of Severe Intellectual Disability, Epilepsy, and Cataracts Due to Fatty Acyl-CoA Reductase 1 Deficiency
In: American Journal of Human Genetics 95 (2014), p. 602-10
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2014.10.003
Hackenberg A., Baumer A., Sticht H., Schmitt B., Kroell-Seger J., Wille D., Joset P., Papuc S., Rauch A., Plecko B.:
Infantile epileptic encephalopathy, transient choreoathetotic movements, and hypersomnia due to a De Novo missense mutation in the SCN2A gene
In: Neuropediatrics 45 (2014), p. 261-4
ISSN: 0174-304X
DOI: 10.1055/s-0034-1372302
Havlicek S., Kohl Z., Mishra HK., Prots I., Eberhardt E., Denguir N., Wend H., Ploetz S., Boyer L., Marchetto MCN., Aigner S., Sticht H., Groemer TW., Hehr U., Lampert A., Schlötzer-Schrehardt U., Winkler J., Gage FH., Winner B.:
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons
In: Human Molecular Genetics 23 (2014), p. 2527-41
ISSN: 0964-6906
DOI: 10.1093/hmg/ddt644
Jochmann R., Holz P., Sticht H., Stürzl M.:
Validation of the reliability of computational O-GlcNAc prediction
In: Biochimica Et Biophysica Acta-Proteins and Proteomics 1844 (2014), p. 416-21
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2013.12.002
Kaßler K., Sticht H.:
Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity
In: Journal of Biomolecular Structure & Dynamics 32 (2014), p. 52-64
ISSN: 0739-1102
DOI: 10.1080/07391102.2012.746946
Lind J., Backert S., Pfleiderer K., Berg DE., Yamaoka Y., Sticht H., Tegtmeyer N.:
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains
In: PLoS ONE 9 (2014), p. e96488
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0096488
Meiselbach H., Vogel N., Langlhofer G., Stangl S., Schleyer B., Bahnassawy L., Sticht H., Breitinger HG., Becker CM., Villmann C.:
Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior
In: Journal of Biological Chemistry 289 (2014), p. 29135-47
ISSN: 0021-9258
DOI: 10.1074/jbc.M114.559138
Milbradt J., Kraut A., Hutterer C., Sonntag E., Schmeiser C., Ferro M., Wagner S., Lenac T., Claus C., Pinkert S., Hamilton ST., Rawlinson WD., Sticht H., Coute Y., Marschall M.:
Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus
In: Molecular & Cellular Proteomics 13 (2014), p. 2132-46
ISSN: 1535-9476
DOI: 10.1074/mcp.M113.035782
Yoshiko Murakami, Hasan Tawamie, Yusuke Maeda, Christian Büttner, Rebecca Buchert, Farah Radwan, Stefanie Schaffer, Heinrich Sticht, Michael Aigner, André Reis, Taroh Kinoshita, Rami Abou Jamra:
Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy
In: PLoS Genetics 10 (2014), p. e1004320
ISSN: 1553-7390
DOI: 10.1371/journal.pgen.1004320
Scherer M., Klingl S., Sevvana M., Otto V., Schilling EM., Stump J., Müller R., Reuter N., Sticht H., Muller Y., Stamminger T.:
Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions
In: PLoS Pathogens 10 (2014), p. e1004512
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1004512
Socher E., Sticht H., Horn A.:
The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length
In: Acs Chemical Neuroscience 5 (2014), p. 161-167
ISSN: 1948-7193
DOI: 10.1021/cn400208r
Spindler N., Diestel U., Stump J., Wiegers AK., Winkler T., Sticht H., Mach M., Muller Y.:
Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody
In: PLoS Pathogens 10 (2014), p. e1004377
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1004377
Stump J., Sticht H.:
Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms
In: Journal of Molecular Modeling 20 (2014), p. 2192
ISSN: 1610-2940
DOI: 10.1007/s00894-014-2192-x

App C., Knop J., Huff T., Sticht H., Hannappel E.:
Thymosin ?4 and tissue transglutaminase. Molecular characterization of cyclic thymosin ?4
In: Protein Journal 32 (2013), p. 484-92
ISSN: 1572-3887
DOI: 10.1007/s10930-013-9507-0
Dornieden S., Mueller-Schiffmann A., Sticht H., Jiang N., Cinar Y., Woerdehoff M., Korth C., Funke SA., Willbold D.:
Characterization of a single-chain variable fragment recognizing a linear epitope of a?: a biotechnical tool for studies on Alzheimer's disease?
In: PLoS ONE 8 (2013), p. e59820
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0059820
Eißmann K., Müller S., Sticht H., Jung S., Zou P., Jiang S., Gross A., Eichler J., Fleckenstein B., Reil H.:
HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop
In: PLoS ONE 8 (2013), p. e54452
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0054452
Graf L., Webel R., Wagner S., Hamilton ST., Rawlinson WD., Sticht H., Marschall M.:
The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins
In: Viruses 5 (2013), p. 3213-30
ISSN: 1999-4915
DOI: 10.3390/v5123213
Gregor A., Oti M., Kouwenhoven EN., Hoyer J., Sticht H., Ekici AB., Kjaergaard S., Rauch A., Stunnenberg HG., Uebe S., Vasileiou G., Reis A., Zhou H., Zweier C.:
De novo mutations in the genome organizer CTCF cause intellectual disability
In: American Journal of Human Genetics 93 (2013), p. 124-31
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2013.05.007
Grießl M., Schmid B., Kaßler K., Braunsmann C., Ritter R., Barlag B., Stierhof YD., Sturm KU., Danzer CA., Wagner C., Schaeffer TE., Sticht H., Hensel M., Muller Y.:
Structural insight into the giant Ca²?-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells
In: Structure 21 (2013), p. 741-52
ISSN: 0969-2126
DOI: 10.1016/j.str.2013.02.020
Grosch M., Gruener B., Spranger S., Stuetz AM., Rausch T., Korbel JO., Seelow D., Nuernberg P., Sticht H., Lausch E., Zabel B., Winterpacht A., Tagariello A.:
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype
In: Matrix Biology 32 (2013), p. 387-92
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2013.05.001
Hofmann K., Zweier M., Sticht H., Zweier C., Wittmann W., Hoyer J., Uebe S., Van Haeringen A., Thiel C., Ekici AB., Reis A., Rauch A.:
Biallelic SEMA3A defects cause a novel type of syndromic short stature
In: American Journal of Medical Genetics Part A 161A (2013), p. 2880-9
ISSN: 1552-4825
DOI: 10.1002/ajmg.a.36250
Husar-Memmer E., Ekici AB., Al Kaissi A., Sticht H., Manger B., Schett G., Zwerina J.:
Premature Osteoarthritis as Presenting Sign of Type II Collagenopathy: A Case Report and Literature Review
In: Seminars in Arthritis and Rheumatism 42 (2013), p. 355-60
ISSN: 0049-0172
DOI: 10.1016/j.semarthrit.2012.05.002
Jardin C., Stefani A., Eberhardt M., Huber J., Sticht H.:
An information-theoretic classification of amino acids for the assessment of interfaces in protein-protein docking
In: Journal of Molecular Modeling 19 (2013), p. 3901-10
ISSN: 1610-2940
DOI: 10.1007/s00894-013-1916-7
Kahler A., Sticht H., Horn A.:
Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study
In: PLoS ONE 8 (2013), p. e70521
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0070521
Koerber A., Moessner R., Renner R., Sticht H., Wilsmann-Theis D., Schulz P., Sticherling M., Traupe H., Hüffmeier U.:
Mutations in IL36RN in patients with generalized pustular psoriasis
In: Journal of Investigative Dermatology 133 (2013), p. 2634-7
ISSN: 0022-202X
DOI: 10.1038/jid.2013.214
Rauh R., Söll D., Härteis S., Diakov A., Nesterov V., Krüger B., Sticht H., Korbmacher C.:
A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect
In: American Journal of Physiology-Lung Cellular and Molecular Physiology 304 (2013), p. L43-55
ISSN: 1040-0605
DOI: 10.1152/ajplung.00093.2012
Scherer M., Reuter N., Wagenknecht N., Otto V., Sticht H., Stamminger T.:
Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments
In: Journal of General Virology 94 (2013), p. 1373-84
ISSN: 0022-1317
DOI: 10.1099/vir.0.051078-0
Schmeiser C., Borst E., Sticht H., Marschall M., Milbradt J.:
The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import
In: Journal of General Virology 94 (2013), p. 2056-69
ISSN: 0022-1317
DOI: 10.1099/vir.0.052571-0
Seebahn A., Sticht H., Enz R.:
Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors
In: Methods in Enzymology 520 (2013), p. 257-79
ISSN: 0076-6879
DOI: 10.1016/B978-0-12-391861-1.00012-5
Spindler N., Ruecker P., Pötzsch S., Diestel U., Sticht H., Martin-Parras L., Winkler T., Mach M.:
Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus
In: Journal of Virology 87 (2013), p. 8927-39
ISSN: 0022-538X
DOI: 10.1128/JVI.00434-13
Xiang W., Weisbach VG., Sticht H., Seebahn A., Bussmann J., Zimmermann R., Becker CM.:
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes
In: Archives of Biochemistry and Biophysics 529 (2013), p. 34-44
ISSN: 0003-9861
DOI: 10.1016/j.abb.2012.11.002
de Jong SJ., Albrecht JC., Giehler F., Kieser A., Sticht H., Biesinger B.:
Noncanonical NF-?B activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif
In: Science Signaling 6 (2013), p. ra27
ISSN: 1937-9145
DOI: 10.1126/scisignal.2003309

Härteis S., Schaal D., Brauer F., Brueschke S., Schweimer K., Rauh R., Sticht H., Roesch P., Schwarzinger S., Korbmacher C.:
An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation
In: Cellular Physiology and Biochemistry 29 (2012), p. 761-74
ISSN: 1015-8987
DOI: 10.1159/000312590
Jardin C., Sticht H.:
Identification of the structural features that mediate binding specificity in the recognition of STAT proteins by dual-specificity phosphatases
In: Journal of Biomolecular Structure & Dynamics 29 (2012), p. 777-92
ISSN: 0739-1102
DOI: 10.1080/07391102.2012.10507413
Mazumder ED., Jardin C., Vogel B., Heck E., Scholz B., Lengenfelder D., Sticht H., Enßer A.:
A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip
In: PLoS ONE 7 (2012), p. e34306
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034306
Meier J., Kaßler K., Sticht H., Eichler J.:
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
In: Beilstein Journal of Organic Chemistry 8 (2012), p. 1858-66
ISSN: 1860-5397
DOI: 10.3762/bjoc.8.214
Milbradt J., Auerochs S., Sevvana M., Muller Y., Sticht H., Marschall M.:
Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53
In: Journal of Biological Chemistry 287 (2012), p. 24004-16
ISSN: 0021-9258
DOI: 10.1074/jbc.M111.331207
Mueller-Schiffmann A., Sticht H., Korth C.:
Hybrid compounds: from simple combinations to nanomachines
In: Biodrugs 26 (2012), p. 21-31
ISSN: 1173-8804
DOI: 10.2165/11597630-000000000-00000
Othersen O., Stefani A., Huber J., Sticht H.:
Application of information theory to feature selection in protein docking
In: Journal of Molecular Modeling 18 (2012), p. 1285-97
ISSN: 1610-2940
DOI: 10.1007/s00894-011-1157-6
Pasutto F., Keller KE., Weisschuh N., Sticht H., Samples JR., Yang YF., Zenkel M., Schlötzer-Schrehardt U., Mardin C., Frezzotti P., Edmunds B., Kramer PL., Gramer E., Reis A., Acott TS., Wirtz MK.:
Variants in ASB10 are associated with open-angle glaucoma
In: Human Molecular Genetics 21 (2012), p. 1336-49
ISSN: 0964-6906
DOI: 10.1093/hmg/ddr572
Tagariello A., Breuer C., Birkner Y., Schmidt S., Koch AM., Cesnjevar R., Rueffer A., Dittrich S., Schneider H., Winterpacht A., Sticht H., Doetsch J., Toka O.:
Functional null mutations in the gonosomal homologue gene TBL1Y are associated with non-syndromic coarctation of the aorta
In: Current Molecular Medicine 12 (2012), p. 199-205
ISSN: 1566-5240
DOI: 10.2174/156652412798889027
Webel R., Solbak SMO., Held C., Milbradt J., Groß A., Eichler J., Wittenberg T., Jardin C., Sticht H., Fossen T., Marschall M.:
Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-? binding
In: Journal of General Virology 93 (2012), p. 1756-68
ISSN: 0022-1317
DOI: 10.1099/vir.0.040592-0

Duetting E., Schroeder-Kress N., Sticht H., Enz R.:
Sumo E3 ligases are expressed in the retina and regulate sumoylation of the metabotropic glutamate receptor 8b.
In: Biochemical Journal (2011), p. 365-371
ISSN: 0264-6021
DOI: 10.1042/BJ20101854
Haberlova J., Mazanec R., Ridzon P., Barankova L., Nuernberg G., Nuernberg P., Sticht H., Hühne K., Seeman P., Rautenstrauss B.:
Phenotypic variability in a large Czech family with a Dynamin 2-associated Charcot-Marie-Tooth neuropathy
In: Journal of Neurogenetics 25 (2011), p. 182-8
ISSN: 0167-7063
DOI: 10.3109/01677063.2011.627484
Hochdoerffer K., Maerz-Berberich J., Nage-Steger L., Epple M., Meyer-Zaika W., Horn A., Sticht H., Sinha S., Bitan G., Schrader T.:
Rational design of ?-sheet ligands against A?42-induced toxicity
In: Journal of the American Chemical Society 133 (2011), p. 4348-58
ISSN: 0002-7863
DOI: 10.1021/ja107675n
Kaßler K., Meier J., Eichler J., Sticht H.:
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides
In: Advances in Bioinformatics 2011 (2011), p. 736593
ISSN: 1687-8027
DOI: 10.1155/2011/736593
Mandery K., Sticht H., Bujok K., Schmidt I., Fahrmayr C., Balk B., Fromm M., Gläser H.:
Functional and Structural Relevance of Conserved Positively Charged Lysine Residues in Organic Anion Transporting Polypeptide 1B3
In: Molecular Pharmacology 80 (2011), p. 400-6
ISSN: 0026-895X
DOI: 10.1124/mol.111.071282
Meiselbach H., Sticht H.:
Effect of the SH3-SH2 domain linker sequence on the structure of Hck kinase
In: Journal of Molecular Modeling 17 (2011), p. 1927-34
ISSN: 1610-2940
DOI: 10.1007/s00894-010-0897-z
Pötzsch S., Spindler N., Wiegers AK., Fisch T., Ruecker P., Sticht H., Grieb N., Baroti T., Weisel F., Stamminger T., Martin-Parras L., Mach M., Winkler T.:
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies
In: PLoS Pathogens 7 (2011), Article No.: e1002172
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1002172
Rotthier A., Penno A., Rautenstrauss B., Auer-Grumbach M., Stettner GM., Asselbergh B., Van Hoof K., Sticht H., Levy N., Timmerman V., Hornemann T., Janssens K.:
Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I
In: Human Mutation 32 (2011), p. E2211-25
ISSN: 1059-7794
DOI: 10.1002/humu.21481
Ruecker P., Horn A., Meiselbach H., Sticht H.:
A comparative study of HIV-1 and HTLV-I protease structure and dynamics reveals a conserved residue interaction network
In: Journal of Molecular Modeling 17 (2011), p. 2693-705
ISSN: 1610-2940
DOI: 10.1007/s00894-011-0971-1
Schulze C., Sticht H., Meyerhoff P., Dietrich P.:
Differential contribution of EF-hands to the Ca²?-dependent activation in the plant two-pore channel TPC1
In: Plant Journal 68 (2011), p. 424-32
ISSN: 0960-7412
DOI: 10.1111/j.1365-313X.2011.04697.x
Seebahn A., Dinkel H., Mohrlüder J., Hartmann R., Vogel N., Becker CM., Sticht H., Enz R.:
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors.
In: Febs Letters (2011), p. 511-516
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.12.042
Templin C., Ghadri JR., Rougier JS., Baumer A., Kaplan V., Albesa M., Sticht H., Rauch A., Puleo C., Hu D., Barajas-Martinez H., Antzelevitch C., Luescher TF., Abriel H., Duru F.:
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)
In: European Heart Journal 32 (2011), p. 1077-88
ISSN: 0195-668X
DOI: 10.1093/eurheartj/ehr076

Rauh R., Diakov A., Tzschoppe A., Korbmacher J., Azad AK., Cuppens H., Cassiman JJ., Dötsch J., Sticht H., Korbmacher C.:
A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition
In: The Journal of Physiology 588 (2010), p. 1211-1225
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2009.180224

Muhl D., Jeßberger N., Hasselt K., Jardin C., Sticht H., Burkovski A.:
DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR
In: Bmc Molecular Biology 10 (2009), p. 73
ISSN: 1471-2199
DOI: 10.1186/1471-2199-10-73

Rose M., Dütting E., Schröder N., Sticht H., Brandstätter JH., Enz R.:
PNUTS forms a trimeric protein complex with GABAC receptors and protein phosphatase 1.
In: Molecular and Cellular Neuroscience (2008), p. 808-819
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2008.01.004

Cheusova T., Khan MA., Schubert S., Gavin AC., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner HR., Hashemolhosseini S.:
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.
In: Genes & Development (2006), p. 1800-1816
ISSN: 0890-9369
DOI: 10.1101/gad.375206
Homeyer N., Horn A., Lanig H., Sticht H.:
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine.
In: Journal of Molecular Modeling 12 (2006), p. 281-9
ISSN: 0948-5023
DOI: 10.1007/s00894-005-0028-4
Meiselbach H., Sticht H., Enz R.:
Structural analysis of the protein phosphatase 1 docking motif: Molecular description of the binding specificity identifies new ligands.
In: Chemistry & Biology (2006), p. 49-59
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2005.10.009

Croci C., Sticht H., Brandstätter JH., Enz R.:
Group I metabotropic glutamate receptors bind to protein phosphatase 1C: Mapping and modeling of interacting sequences.
In: Journal of Biological Chemistry (2003), p. 50682-50690
ISSN: 0021-9258
DOI: 10.1074/jbc.M305764200

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