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2019

Sock E, Wegner M.
Transcriptional control of myelination and remyelination.
Glia. 2019 Apr 30. doi: 10.1002/glia.23636. [Epub ahead of print] Review.

Cantone M, Küspert M, Reiprich S, Lai X, Eberhardt M, Göttle P, Beyer F, Azim K, Küry P, Wegner M, Vera J.
A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation.
Glia. 2019 May;67(5):825-843. doi: 10.1002/glia.23569. Epub 2019 Feb 7.

2018

Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J.
Oligodendroglial A-synucleinopathy driven neuroinflammation in multiple system atrophy.
Brain Pathol. 2018 Nov 16. doi: 10.1111/bpa.12678. [Epub ahead of print]

Kozlenkov A, Li J, Apontes P, Hurd YL, Byne WM, Koonin EV, Wegner M, Mukamel EA, Dracheva S.
A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.
Sci Adv. 2018;4(9):eaau6190

Rich CA, Perera SN, Andratschke J, Stolt CC, Buehler DP, Southard-Smith EM, Wegner M, Britsch S, Baker CVH.
Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting.
Glia. 2018 Sep 26. doi: 10.1002/glia.23515. [Epub ahead of print]

Prochnicki A, Amann K, Wegner M, Sock E, Pfister E, Shankland S, Pippin J, Daniel C.
Characterization of Glomerular Sox9(+) Cells in Anti-Glomerular Basement Membrane Nephritis in the Rat.
Am J Pathol. 2018;188(11): 2529-2541

Menzel-Severing J, Zenkel M, Polisetti N, Sock E, Wegner M, Kruse FE, Schlötzer-Schrehardt U.
Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells.
Sci Rep. 2018;8(1): 10268

Jacob A, Wüst HM, Thalhammer JM, Fröb F, Küspert M, Reiprich S, Balta EA, Lie DC, Wegner M, Sock E. The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis.
J Neurochem. 2018;146(3): 251-268

Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M.
Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.
Nat Commun. 2018;9(1): 1667

Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A.
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).
Kidney Int. 2018;93(5): 1142-1153

Truch K, Arter J, Turnescu T, Weider M, Hartwig AC, Tamm ER, Sock E, Wegner M.
Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease.
Hum Mol Genet. 2018;27(6): 1078-1092

Parfejevs V, Debbache J, Shakhova O, Schaefer SM, Glausch M, Wegner M, Suter U, Riekstina U, Werner S, Sommer L.
Injury-activated glial cells promote wound healing of the adult skin in mice.
Nat Commun. 2018;9(1): 236

Turnescu T, Arter J, Reiprich S, Tamm ER, Waisman A, Wegner M.
Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes.
Glia. 2018;66(2): 279-294

2017

Duncan GJ, Plemel JR, Assinck P, Manesh SB, Muir FGW, Hirata R, Berson M, Liu J, Wegner M, Emery B, Moore GRW, Tetzlaff W.
Myelin regulatory factor drives remyelination in multiple sclerosis.
Acta Neuropathol. 2017;134(3): 403-422

Marathe HG, Watkins-Chow DE, Weider M, Hoffmann A, Mehta G, Trivedi A, Aras S, Basuroy T, Mehrotra A, Bennett DC, Wegner M, Pavan WJ, de la Serna IL.
BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation.
Nucleic Acids Res. 2017;45(11): 6442-6458

Reiprich S, Cantone M, Weider M, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M.
Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs.
Glia. 2017;65(7): 1089-1102

Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M.
Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
J Neurochem. 2017;140(2): 245-256

Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB.
Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy.
Muscle Nerve. 2017;55(5): 761-765

Weider M, Wegner M.
SoxE factors: Transcriptional regulators of neural differentiation and nervous system development.
Semin Cell Dev Biol. 2017;63: 35-42

2016

Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage FH, Winkler J
?-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.
Acta Neuropathol (Berl). 2016;132(1): 59-75

Küspert M, Wegner M
SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors.
Brain Res. 2016;1638(Pt B): 167-82

Stolt CC, Wegner M
Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination.
Brain Res. 2016;1641(Pt A): 101-10

Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJM, Fan GP, Zhu J, Dupree JL, Casaccia P
Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage
Cell Rep. 2016;15(4): 748-760

Baroti T, Zimmermann Y, Schillinger A, Liu L, Lommes P, Wegner M, Stolt CC
Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.
Glia. 2016;64(1): 122-38

Muth KN, Piefke S, Weider M, Sock E, Hermans-Borgmeyer I, Wegner M, Küspert M
The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes.
Glia. 2016;64(12): 2120-2132

Baroti T, Schillinger A, Wegner M, Stolt CC
Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
J Neurochem. 2016;136(2): 316-28

Quintes S, Brinkmann BG, Ebert M, Fröb F, Kungl T, Arlt FA, Tarabykin V, Huylebroeck D, Meijer D, Suter U, Wegner M, Sereda MW, Nave KA
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nat Neurosci. 2016;19(8): 1050-9

Kozlenkov A, Wang M, Roussos P, Rudchenko S, Barbu M, Bibikova M, Klotzle B, Dwork AJ, Zhang B, Hurd YL, Koonin EV, Wegner M, Dracheva S
Substantial DNA methylation differences between two major neuronal subtypes in human brain.
Nucleic Acids Res. 2016;44(6): 2593-612

2015

Wegener A, Deboux C, Bachelin C, Frah M, Kerninon C, Seilhean D, Weider M, Wegner M, Nait-Oumesmar B
Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination.
Brain. 2015;138(Pt 1): 120-35

Reiprich S, Wegner M
From CNS stem cells to neurons and glia: Sox for everyone.
Cell Tissue Res. 2015;359(1): 111-24

Amaya DA, Wegner M, Stolt CC, Chehrehasa F, Ekberg JAK, St John JA
Axonal Debris From Degenerating Overextended Axons Are Phagocytosed by Radial Glia During Early Development of the Olfactory Bulb
Chem Senses. 2015;40(5): 359-360

Quiroga AC, Stolt CC, Del Corral RD, Dimitrov S, Pérez-Alcalá S, Sock E, Barbas JA, Wegner M, Morales AV
Sox5 controls dorsal progenitor and interneuron specification in the spinal cord.
Dev Neurobiol. 2015;75(5): 522-38

Knop J, App C, Huff T, Iavarone F, Castagnola M, Hannappel E
Identification of PDGF-BB binding to thymosin ?4 by chemical cross-linking.
Expert Opin Biol Ther. 2015;15 Suppl 1: S147-54

Cabras T, Iavarone F, Martelli C, Delfino D, Rossetti DV, Inserra I, Manconi B, Desiderio C, Messana I, Hannappel E, Faa G, Castagnola M
High-resolution mass spectrometry for thymosins detection and characterization.
Expert Opin Biol Ther. 2015;15 Suppl 1: S191-201

Ettle B, Reiprich S, Wegner M, Masliah E, Winkler J
Targeting myelin as potential interventional strategy for multiple system atrophy
Glia. 2015;63 1: E138-E138

Kuspert M, Wegner M
The role of zinc finger transcription factor Zfp276 during glial development
Glia. 2015;63 1: E191-E191

Reiprich S, Hoffmann SA, Hos D, Kuspert M, Lang RA, Lovell-Badge R, Wegner M
Sox2 beyond its stem cell role – New functions in oligodendroglial differentiation
Glia. 2015;63 1: E191-E192

Wegener A, Weider M, Schmitt C, Kuspert M, Hillgartner S, Bosl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M
Increased Sox10 levels directly convert satellite Glia into oligodendrocyte-like cells in vivo
Glia. 2015;63 1: E194-E194

Baroti T, Sock E, Wegner M, Stolt C
Impact of transcription factor Sox13 on oligodendrocyte development in the embryonic mouse spinal cord
Glia. 2015;63 1: E197-E198

Frob F, Kuspert M, Sock E, Tamm E, Fukunaga R, Wegner M
The influence of mDomino/p400 on Schwann cell development in mice
Glia. 2015;63 1: E268-E269

Muth KN, Kuspert M, Sock E, Wegner M
Characterization of DUSP15/VHY as a regulatory target of Sox10 and Myrf
Glia. 2015;63 1: E273-E274

Wegner M
The role of chromatin remodeling in myelinating glia
Glia. 2015;63 1: E31-E31

Herrmann D, Straubinger M, Hashemolhosseini S
Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3?, and Dok-7 proteins and phosphorylates the latter two.
J Biol Chem. 2015;290(37): 22370-84

Amaya DA, Wegner M, Stolt CC, Chehrehasa F, Ekberg JA, St John JA
Radial glia phagocytose axonal debris from degenerating overextending axons in the developing olfactory bulb.
J Comp Neurol. 2015;523(2): 183-96

Kim GJ, Sock E, Buchberger A, Just W, Denzer F, Hoepffner W, German J, Cole T, Mann J, Seguin JH, Zipf W, Costigan C, Schmiady H, Rostásy M, Kramer M, Kaltenbach S, Rösler B, Georg I, Troppmann E, Teichmann AC, Salfelder A, Widholz SA, Wieacker P, Hiort O, Camerino G, Radi O, Wegner M, Arnold HH, Scherer G
Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46,XY or 46,XX disorder of sex development.
J Med Genet. 2015;52(4): 240-7

Arter J, Wegner M
Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells.
J Neurochem. 2015;132(4): 384-93

Bischof M, Weider M, Küspert M, Nave KA, Wegner M
Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.
J Neurosci. 2015;35(1): 21-35

Chen C, Lee GA, Pourmorady A, Sock E, Donoghue MJ
Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes.
J Neurosci. 2015;35(29): 10629-42

Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.
Mamm Genome. 2015;26(1-2): 80-93

Buslei R, Strissel PL, Henke C, Schey R, Lang N, Ruebner M, Stolt CC, Fabry B, Buchfelder M, Strick R
Activation and regulation of endogenous retroviral genes in the human pituitary gland and related endocrine tumours.
Neuropathol Appl Neurobiol. 2015;41(2): 180-200

Shakhova O, Cheng P, Mishra PJ, Zingg D, Schaefer SM, Debbache J, Häusel J, Matter C, Guo T, Davis S, Meltzer P, Mihic-Probst D, Moch H, Wegner M, Merlino G, Levesque MP, Dummer R, Santoro R, Cinelli P, Sommer L
Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.
PLoS Genet. 2015;11(1): e1004877

Weider M, Wegener A, Schmitt C, Küspert M, Hillgärtner S, Bösl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M
Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells.
PLoS Genet. 2015;11(2): e1005008

Henke C, Strissel PL, Schubert MT, Mitchell M, Stolt CC, Faschingbauer F, Beckmann MW, Strick R
Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon–derived family during mouse placentogenesis.
Retrovirology. 2015;12: 9

Lang H, Xing Y, Brown LN, Samuvel DJ, Panganiban CH, Havens LT, Balasubramanian S, Wegner M, Krug EL, Barth JL
Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve.
Sci Rep. 2015;5: 13383

2014

App C, Knop J, Huff T, Seebahn A, Becker CM, Iavarone F, Castagnola M, Hannappel E
Peptide labeling with photoactivatable trifunctional cadaverine derivative and identification of interacting partners by biotin transfer.
Anal Biochem. 2014;456: 14-21

Paul MH, Harvey RP, Wegner M, Sock E
Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types.
Cell Mol Life Sci. 2014;71(15): 2931-45

Huelsbrink Robert, Hashemolhosseini Said
Lambert-Eaton myasthenic syndrome – Diagnosis, pathogenesis and therapy
Clin Neurophysiol. 2014;125(12): 2328-2336

Al Haj A, Mazur AJ, Buchmeier S, App C, Theiss C, Silvan U, Schoenenberger CA, Jockusch BM, Hannappel E, Weeds AG, Mannherz HG
Thymosin beta4 inhibits ADF/cofilin stimulated F-actin cycling and hela cell migration: Reversal by active Arp2/3 complex.
Cytoskeleton (Hoboken). 2014;71(2): 95-107

Hoffmann SA, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
Development. 2014;141(1): 39-50

Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.
Development. 2014;141(3): 548-55

Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-Schrehardt U, Winkler J, Winner B
Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia.
Hum Mol Genet. 2014;23(18): 4859-74

Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J
Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
Mol Cell Neurosci. 2014;62: 68-78

Ettle B, May VEL, Reiprich S, Xiang W, Winner B, Wegner M, Masliah E, Winkler J
Impaired maturation of oligodendrocyte precursors in multiple system atrophy
Mov Disord. 2014;29 1: S9-S10

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Nat Commun. 2014;5: 3970

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, App C, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease.
Nat Med. 2014;20(3): 313-8

Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila C, Deneen B
Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes.
Nat Neurosci. 2014;17(10): 1322-9

May VE, Ettle B, Poehler AM, Nuber S, Ubhi K, Rockenstein E, Winner B, Wegner M, Masliah E, Winkler J
?-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.
Neurobiol Aging. 2014;35(10): 2357-68

Mao YY, Reiprich S, Wegner M, Fritzsch B
Targeted Deletion of Sox10 by Wnt1-cre Defects Neuronal Migration and Projection in the Mouse Inner Ear
PLoS ONE. 2014;9(4): –

2013

Knop J, App C, Horn AH, Iavarone F, Castagnola M, Hannappel E
High-resolution HPLC-ESI-MS characterization of the contact sites of the actin-thymosin ?(4) complex by chemical and enzymatic cross-linking.
Biochemistry. 2013;52(33): 5553-62

Weider M, Reiprich S, Wegner M
Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia.
Biol Chem. 2013;394(12): 1583-93

Barraud P, St John JA, Stolt CC, Wegner M, Baker CV
Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons.
Biol Open. 2013;2(7): 750-9

Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB
Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.
Brain. 2013;136(Pt 2): 549-63

Wegner M
Mighty bugs: leprosy bacteria turn schwann cells into stem cells.
Cell. 2013;152(1-2): 15-6

Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
Development. 2013;140(4): 740-50

Henke C, Ruebner M, Faschingbauer F, Stolt CC, Schaefer N, Lang N, Beckmann MW, Strissel PL, Strick R
Regulation of murine placentogenesis by the retroviral genes Syncytin-A, Syncytin-B and Peg10.
Differentiation. 2013;85(4-5): 150-60

Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, Watanabe S
Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development.
FEBS Lett. 2013;587(4): 358-63

Trost A, Schroedl F, Lange S, Rivera FJ, Tempfer H, Korntner S, Stolt CC, Wegner M, Bogner B, Kaser-Eichberger A, Krefft K, Runge C, Aigner L, Reitsamer HA
Neural crest origin of retinal and choroidal pericytes.
Invest Ophthalmol Vis Sci. 2013;54(13): 7910-21

Vogl MR, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave KA, Wegner M
Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.
J Neurosci. 2013;33(15): 6679-90

Bujalka H, Koenning M, Jackson S, Perreau VM, Pope B, Hay CM, Mitew S, Hill AF, Lu QR, Wegner M, Srinivasan R, Svaren J, Willingham M, Barres BA, Emery B
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.
PLoS Biol. 2013;11(8): e1001625

Hornig J, Fröb F, Vogl MR, Hermans-Borgmeyer I, Tamm ER, Wegner M
The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.
PLoS Genet. 2013;9(10): e1003907

Harris ML, Buac K, Shakhova O, Hakami RM, Wegner M, Sommer L, Pavan WJ
A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors.
PLoS Genet. 2013;9(7): e1003644

App C, Knop J, Huff T, Sticht H, Hannappel E
Thymosin ?4 and tissue transglutaminase. Molecular characterization of cyclic thymosin ?4.
Protein J. 2013;32(6): 484-92