Publikationen

Publikationen AG Lie

Billmann C., Schäffner I., Heppt J., Lie DC.:
Analysis of β-Catenin Signalling Activity Suggests Differential Regulation of Ontogenetically Distinct Dentate Granule Neuron Populations
In: International Journal of Developmental Neuroscience 85 (2025), Art.Nr.: e70009
ISSN: 0736-5748
DOI: 10.1002/jdn.70009

Kochan SM., Malo MC., Jevtic M., Jahn-Kelleter HM., Wani GA., Ndoci K., Pérez-Revuelta L., Gaedke F., Schäffner I., Lie DC., Schauss A., Bergami M.:
Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons
In: Neuron (2024)
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2024.03.013
Rasetto NB., Giacomini D., Berardino AA., Waichman TV., Beckel MS., Di Bella DJ., Brown J., Davies-Sala MG., Gerhardinger C., Lie DC., Arlotta P., Chernomoretz A., Schinder AF.:
Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus
In: Science Advances 10 (2024), Art.Nr.: eadp6039
ISSN: 2375-2548
DOI: 10.1126/sciadv.adp6039

Akdas EY., Turan S., Guhathakurta D., Ekici AB., Salar S., Lie DC., Winner B., Fejtová A.:
CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome
In: Stem Cell Research 67 (2023), S. 103012
ISSN: 1873-5061
DOI: 10.1016/j.scr.2022.103012
URL: https://www.sciencedirect.com/science/article/pii/S1873506122003610?via=ihub
Bonzano S., Dallorto E., Molineris I., Michelon F., Crisci I., Gambarotta G., Neri F., Oliviero S., Beckervordersandforth R., Lie DC., Peretto P., Bovetti S., Studer M., De Marchis S.:
NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome.
In: Disease Models & Mechanisms 16 (2023)
ISSN: 1754-8403
DOI: 10.1242/dmm.049854

Schäffner I., Wittmann MT., Vogel T., Lie DC.:
Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1
In: Molecular Psychiatry (2022)
ISSN: 1359-4184
DOI: 10.1038/s41380-022-01497-8

Gonzalez Acera M., Bubeck M., Mascia F., Diemand L., Sturm G., Kuehl AA., Atreya R., Lie DC., Neurath M., Schumann M., Klose CSN., Trajanoski Z., Becker C., Patankar J.:
Dynamic, transient, and robust increase in the innervation of the inflamed mucosa in inflammatory bowel diseases
In: Cells 10 (2021), Art.Nr.: 2253
ISSN: 2073-4409
DOI: 10.3390/cells10092253
Wittmann MT., Katada S., Sock E., Kirchner P., Ekici AB., Wegner M., Nakashima K., Lie DC., Reis A.:
scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse
In: Development 148 (2021), Art.Nr.: dev196022
ISSN: 1477-9129
DOI: 10.1242/DEV.196022

Braun K., Häberle B., Wittmann MT., Lie DC.:
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice
In: BMC Neuroscience 21 (2020), Art.Nr.: 50
ISSN: 1471-2202
DOI: 10.1186/s12868-020-00602-3
Börstler T., Wend H., Krumbiegel M., Kavyanifar A., Reis A., Lie DC., Winner B., Turan S.:
CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome
In: Stem Cell Research 47 (2020), Art.Nr.: 101889
ISSN: 1873-5061
DOI: 10.1016/j.scr.2020.101889
Börstler T., Wend H., Krumbiegel M., Kavyanifar A., Wiesmann da Silva Reis A., Lie DC., Winner B., Turan S.:
CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome
In: Stem Cell Research 47 (2020), Art.Nr.: 101889
ISSN: 1873-5061
DOI: 10.1016/j.scr.2020.101889
Heppt J., Wittmann MT., Schäffner I., Billmann C., Zhang J., Vogt-Weisenhorn D., Prakash N., Wurst W., Taketo MM., Lie DC.:
β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons
In: EMBO Journal (2020)
ISSN: 0261-4189
DOI: 10.15252/embj.2020104472
Turan S., Winner B., Winner B., Krumbiegel M., Wiesmann da Silva Reis A., Lie DC., Börstler T., Wend H., Krumbiegel M., Kavyanifar A., Reis A., Lie DC.:
CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome.
In: Stem Cell Research 47 (2020), S. 101889
ISSN: 1873-5061
DOI: 10.1016/j.scr.2020.101889
Wedel M., Fröb F., Elsesser O., Wittmann MT., Lie DC., Reis A., Wegner M.:
Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation
In: Nucleic Acids Research 48 (2020), S. 4839-4857
ISSN: 0305-1048
DOI: 10.1093/nar/gkaa218
von Wittgenstein J., Zheng F., Wittmann MT., Balta EA., Ferrazzi F., Schäffner I., Häberle B., Valero Aracama MJ., Koehl M., Miranda CJ., Kaspar BK., Ekici AB., Reis A., Abrous DN., Alzheimer C., Lie DC.:
Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation
In: Cerebral Cortex 30 (2020), S. 3731-3743
ISSN: 1047-3211
DOI: 10.1093/cercor/bhz338

Fiebig C., Keiner S., Ebert B., Schäffner I., Jagasia R., Lie DC., Beckervordersandforth R.:
Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion
In: Frontiers in Molecular Neuroscience 12 (2019)
ISSN: 1662-5099
DOI: 10.3389/fnmol.2019.00040
Turan S., Börstler T., Kavyanifar A., Loskarn S., Reis A., Winner B., Lie DC.:
A novel human stem cell model for Coffin-Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival
In: Human Molecular Genetics 28 (2019), S. 2589-2599
ISSN: 0964-6906
DOI: 10.1093/hmg/ddz089
Wendler SMV., Wani G., Goebel J., Conzelmann KK., Lie DC., Bergami M.:
Role of mitochondrial fusion dynamics in adult hippocampal NSC lineage progression
14th European Meeting on Glial Cells in Health and Disease (GLIA) (Porto, 10. Juli 2019 - 13. Juli 2019)
In: GLIA, HOBOKEN: 2019

Armenteros T., Andreu Z., Hortiguela R., Lie DC., Mira H.:
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-27581-0
Balta EA., Schäffner I., Wittmann MT., Sock E., Von Zweydorf F., von Wittgenstein J., Steib K., Heim B., Kremmer E., Häberle B., Ueffing M., Lie DC., Gloeckner CJ.:
Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis
In: Scientific Reports 8 (2018)
ISSN: 2045-2322
DOI: 10.1038/s41598-018-34480-x
Balta EA., Wittmann MT., Jung M., Sock E., Häberle B., Heim B., Von Zweydorf F., Heppt J., von Wittgenstein J., Gloeckner CJ., Lie DC.:
Phosphorylation Modulates the Subcellular Localization of SOX11
In: Frontiers in Molecular Neuroscience 11 (2018)
ISSN: 1662-5099
DOI: 10.3389/fnmol.2018.00211
Jacob A., Wüst H., Thalhammer J., Fröb F., Küspert M., Reiprich S., Balta EA., Lie DC., Wegner M., Sock E.:
The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis
In: Journal of Neurochemistry 146 (2018), S. 251-268
ISSN: 0022-3042
DOI: 10.1111/jnc.14456
Jung M., Häberle B., Tschaikowsky T., Wittmann MT., Balta EA., Stadler VC., Zweier C., Dörfler A., Gloeckner CJ., Lie DC.:
Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons
In: Molecular Autism 9 (2018)
ISSN: 2040-2392
DOI: 10.1186/s13229-018-0200-1
Kavyanifar A., Turan S., Lie DC.:
SoxC transcription factors: multifunctional regulators of neurodevelopment
In: Cell and Tissue Research 371 (2018), S. 91-103
ISSN: 0302-766X
DOI: 10.1007/s00441-017-2708-7
Pozner T., Schray A., Regensburger M., Lie DC., Schlötzer-Schrehardt U., Winkler J., Turan S., Winner B.:
Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons.
In: Frontiers in Neuroscience 12 (2018), S. 914
ISSN: 1662-4548
DOI: 10.3389/fnins.2018.00914
Regensburger M., Prots I., Reimer D., Brachs S., Loskarn S., Lie DC., Mielenz D., Winner B.:
Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis
In: Stem Cell Reports 10 (2018), S. 347-355
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2017.12.010
Schäffner I., Minakaki G., Khan MA., Balta EA., Schlötzer-Schrehardt U., Schwarz TJ., Beckervordersandforth R., Winner B., Webb AE., Depinho RA., Paik J., Wurst W., Klucken J., Lie DC.:
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis
In: Neuron 99 (2018), S. 1188-1203.e6
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2018.08.017

Beckervordersandforth R., Ebert B., Schäffner I., Moss J., Fiebig C., Shin J., Moore DL., Ghosh L., Trinchero MF., Stockburger C., Friedland K., Steib K., von Wittgenstein J., Keiner S., Redecker C., Hoelter SM., Xiang W., Wurst W., Jagasia R., Schinder AF., Ming GL., Toni N., Jessberger S., Song H., Lie DC.:
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
In: Neuron 93 (2017), S. 1518
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.03.008
Hoerster H., Garthe A., Walker TL., Ichwan M., Steiner B., Khan MA., Lie DC., Nicola Z., Ramirez-Rodriguez G., Kempermann G.:
p27kip1 Is Required for Functionally Relevant Adult Hippocampal Neurogenesis in Mice
In: Stem Cells 35 (2017), S. 787-799
ISSN: 1066-5099
DOI: 10.1002/stem.2536
Minakaki G., Menges S., Kittel A., Emmanouilidou E., Schäffner I., Barkovits K., Bergmann A., Rockenstein E., Adame A., Marxreiter F., Mollenhauer B., Galasko D., Buzás EI., Schlötzer-Schrehardt U., Marcus K., Xiang W., Lie DC., Vekrellis K., Masliah E., Winkler J., Klucken J.:
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
In: Autophagy (2017), S. 1-61
ISSN: 1554-8627
DOI: 10.1080/15548627.2017.1395992

Gebara E., Bonaguidi MA., Beckervordersandforth R., Sultan S., Udry F., Gijs PJ., Lie DC., Ming GL., Song H., Toni N.:
Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus
In: Stem Cells 34 (2016), S. 997-1010
ISSN: 1066-5099
DOI: 10.1002/stem.2266

Andreu Z., Khan MA., Gonzalez-Gomez P., Negueruela S., Hortigueela R., Emeterio JS., Ferron SR., Martinez G., Vidal A., Farinas I., Lie DC., Mira H.:
The cyclin-dependent kinase inhibitor p27 kip1 regulates radial stem cell quiescence and neurogenesis in the adult hippocampus
In: Stem Cells 33 (2015), S. 219-29
ISSN: 1066-5099
DOI: 10.1002/stem.1832
Beckervordersandforth R., Zhang CL., Lie DC.:
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis
In: Cold Spring Harbor Perspectives in Biology 7 (2015)
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a018879
Cernilogar FM., Di Giaimo R., Rehfeld F., Cappello S., Lie DC.:
RNA interference machinery-mediated gene regulation in mouse adult neural stem cells
In: BMC Neuroscience 16 (2015), S. 60
ISSN: 1471-2202
DOI: 10.1186/s12868-015-0198-7
Marschallinger J., Schäffner I., Klein B., Gelfert R., Rivera FJ., Illes S., Grassner L., Janssen M., Rotheneichner P., Schmuckermair C., Coras R., Boccazzi M., Chishty M., Lagler FB., Renic M., Bauer HC., Singewald N., Blümcke I., Bogdahn U., Couillard-Despres S., Lie DC., Abbracchio MP., Aigner L.:
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
In: Nature Communications 6 (2015), S. 8466
ISSN: 2041-1723
DOI: 10.1038/ncomms9466

Beckervordersandforth R., Deshpande A., Schäffner I., Huttner H., Lepier A., Lie DC., Goetz M.:
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach
In: Stem Cell Reports 2 (2014), S. 153-62
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2014.01.004
Steib K., Schäffner I., Jagasia R., Ebert B., Lie DC.:
Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain
In: The Journal of Neuroscience 34 (2014), S. 6624-33
ISSN: 1529-2401
DOI: 10.1523/JNEUROSCI.4972-13.2014

Dimidschstein J., Passante L., Dufour A., Van Den Ameele J., Tiberi L., Hrechdakian T., Adams R., Klein R., Lie DC., Jossin Y., Vanderhaeghen P.:
Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration
In: Neuron 79 (2013), S. 1123-35
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2013.07.015
Merz K., Lie DC.:
Evidence that Doublecortin is dispensable for the development of adult born neurons in mice
In: PLoS ONE 8 (2013), S. e62693
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0062693
Ninkovic J., Steiner-Mezzadri A., Jawerka M., Akinci U., Messerdotti G., Petricca S., Fischer J., Von Holst A., Beckers J., Lie DC., Petrik D., Miller E., Tang J., Wu J., Lefebvre V., Demmers J., Eisch A., Metzger D., Crabtree G., Irmler M., Poot R., Goetz M.:
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network
In: Cell Stem Cell 13 (2013), S. 403-18
ISSN: 1934-5909
DOI: 10.1016/j.stem.2013.07.002
Ortega F., Gascon S., Masserdotti G., Deshpande A., Simon C., Fischer J., Dimou L., Lie DC., Schroeder T., Berninger B.:
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
In: Nature Cell Biology 15 (2013), S. 602-13
ISSN: 1465-7392
DOI: 10.1038/ncb2736
Sun M., Hoelter SM., Stepan J., Garrett L., Genius J., Kremmer E., De Angelis MH., Wurst W., Lie DC., Bally-Cuif L., Eder M., Rujescu D., Graw J.:
Crybb2 coding for ?B2-crystallin affects sensorimotor gating and hippocampal function
In: Mammalian Genome 24 (2013), S. 333-48
ISSN: 0938-8990
DOI: 10.1007/s00335-013-9478-7

Garrett L., Lie DC., De Angelis MH., Wurst W., Hoelter SM.:
Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests
In: BMC Neuroscience 13 (2012), S. 61
ISSN: 1471-2202
DOI: 10.1186/1471-2202-13-61
Karow M., Sanchez R., Schichor C., Masserdotti G., Ortega F., Heinrich C., Gascon S., Khan MA., Lie DC., Dellavalle A., Cossu G., Goldbrunner R., Goetz M., Berninger B.:
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells
In: Cell Stem Cell 11 (2012), S. 471-6
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.07.007
Schwarz TJ., Ebert B., Lie DC.:
Stem cell maintenance in the adult mammalian hippocampus: a matter of signal integration?
In: Developmental Neurobiology 72 (2012), S. 1006-15
ISSN: 1932-8451
DOI: 10.1002/dneu.22026
Mu L., Berti L., Masserdotti G., Covic M., Michaelidis T., Doberauer K., Merz K., Rehfeld F., Haslinger A., Wegner Michael, Sock Elisabeth, Lefebvre V., Couillard-Depres S., Aigner L., Berninger B., Lie Dieter Chichung:
SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.
In: Journal of Neuroscience (2012), S. 3067-3080
ISSN: 0270-6474
DOI: 10.1523/JNEUROSCI.4679-11.2012

Herold S., Jagasia R., Merz K., Wassmer K., Lie DC.:
CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis
In: Molecular and Cellular Neuroscience 46 (2011), S. 79-88
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2010.08.008
Karalay O., Doberauer K., Vadodaria KC., Knobloch M., Berti L., Miquelajauregui A., Schwark M., Jagasia R., Taketo MM., Tarabykin V., Lie DC., Jessberger S.:
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
In: Proceedings of the National Academy of Sciences of the United States of America 108 (2011), S. 5807-12
ISSN: 0027-8424
DOI: 10.1073/pnas.1013456108
Khan MA., Lie DC.:
MicroRNA - a contributor to age-associated neural stem cell dysfunction?
In: Aging-Us 3 (2011), S. 182-3
ISSN: 1945-4589
DOI: 10.18632/aging.100297
Merz K., Herold S., Lie DC.:
CREB in adult neurogenesis--master and partner in the development of adult-born neurons?
In: European Journal of Neuroscience 33 (2011), S. 1078-86
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2011.07606.x
Rolyan H., Scheffold A., Heinrich A., Begus-Nahrmann Y., Langkopf BH., Hoelter SM., Vogt-Weisenhorn DM., Liss B., Wurst W., Lie DC., Thal DR., Biber K., Rudolph KL.:
Telomere shortening reduces Alzheimer's disease amyloid pathology in mice
In: Brain 134 (2011), S. 2044-56
ISSN: 0006-8950
DOI: 10.1093/brain/awr133

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