Publikationen

Al Haj A., Ćwikłowska K., Mazur AJ., Brand-Saberi B., Hannappel E., Mannherz HG.:
Concentration-Dependent Pleiotropic Effects of Thymosin Beta4 and Cofilin on the Migratory Activity of Carcinoma Cells
In: International Journal of Translational Medicine 5 (2025), Article No.: 16
ISSN: 2673-8937
DOI: 10.3390/ijtm5020016

Lachowicz JI., Pichiri G., Piludu M., Fais S., Orrù G., Congiu T., Piras M., Faa G., Fanni D., Torre GD., Lopez X., Chandra K., Szczepski K., Jaremko L., Ghosh M., Emwas AH., Castagnola M., Jaremko M., Hannappel E., Coni P.:
Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
In: International Journal of Molecular Sciences 23 (2022), Article No.: 551
ISSN: 1422-0067
DOI: 10.3390/ijms23010551

Kurolap A., Armbruster A., Hershkovitz T., Hauf K., Mory A., Paperna T., Hannappel E., Tal G., Nijem Y., Sella E., Mahajnah M., Ilivitzki A., Hershkovitz D., Ekhilevitch N., Mandel H., Eulenburg V., Baris HN.:
Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine
In: American Journal of Human Genetics 99 (2016), p. 1172-1180
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2016.09.004
Sasaki T., Hanisch FG., Deutzmann R., Sakai LY., Sakuma T., Miyamoto T., Yamamoto T., Hannappel E., Chu ML., Lanig H., Mark K.:
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa
In: Matrix Biology 56 (2016), p. 132-149
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2016.06.003

Cabras T., Iavarone F., Martelli C., Delfino D., Rossetti DV., Inserra I., Manconi B., Desiderio C., Messana I., Hannappel E., Faa G., Castagnola M.:
High-resolution mass spectrometry for thymosins detection and characterization
In: Expert Opinion on Biological Therapy 15 Suppl 1 (2015), p. S191-201
ISSN: 1471-2598
DOI: 10.1517/14712598.2015.1009887
Knop J., App C., Huff T., Iavarone F., Castagnola M., Hannappel E.:
Identification of PDGF-BB binding to thymosin ?4 by chemical cross-linking
In: Expert Opinion on Biological Therapy 15 Suppl 1 (2015), p. S147-54
ISSN: 1471-2598
DOI: 10.1517/14712598.2015.1014793

Al Haj A., Mazur AJ., Buchmeier S., App C., Theiss C., Silvan U., Schoenenberger CA., Jockusch BM., Hannappel E., Weeds AG., Mannherz HG.:
Thymosin beta4 inhibits ADF/cofilin stimulated F-actin cycling and hela cell migration: Reversal by active Arp2/3 complex
In: Cytoskeleton 71 (2014), p. 95-107
ISSN: 1949-3584
DOI: 10.1002/cm.21128
App C., Knop J., Huff T., Seebahn A., Becker CM., Iavarone F., Castagnola M., Hannappel E.:
Peptide labeling with photoactivatable trifunctional cadaverine derivative and identification of interacting partners by biotin transfer
In: Analytical Biochemistry 456 (2014), p. 14-21
ISSN: 0003-2697
DOI: 10.1016/j.ab.2014.04.003
Atreya R., Neumann H., Neufert C., Waldner M., Billmeier U., Zopf Y., Willma M., App C., Münster T., Kessler H., Maas S., Gebhardt B., Heimke-Brinck R., Reuter E., Dörje F., Rau T., Uter W., Wang TD., Kiesslich R., Hannappel E., Neurath M., Vieth M.:
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
In: Nature Medicine 20 (2014), p. 313-8
ISSN: 1078-8956
DOI: 10.1038/nm.3462
Hinkel R., Trenkwalder T., Petersen B., Husada W., Gesenhues F., Lee S., Hannappel E., Bock-Marquette I., Theisen D., Leitner L., Boekstegers P., Cierniewski C., Mueller OJ., Le Noble F., Adams RH., Weinl C., Nordheim A., Reichart B., Weber C., Olson E., Posern G., Deindl E., Niemann H., Kupatt C.:
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2
In: Nature Communications 5 (2014), p. 3970
ISSN: 2041-1723
DOI: 10.1038/ncomms4970

App C., Knop J., Huff T., Sticht H., Hannappel E.:
Thymosin ?4 and tissue transglutaminase. Molecular characterization of cyclic thymosin ?4
In: Protein Journal 32 (2013), p. 484-92
ISSN: 1572-3887
DOI: 10.1007/s10930-013-9507-0
Knop J., App C., Horn A., Iavarone F., Castagnola M., Hannappel E.:
High-resolution HPLC-ESI-MS characterization of the contact sites of the actin-thymosin ?(4) complex by chemical and enzymatic cross-linking
In: Biochemistry 52 (2013), p. 5553-62
ISSN: 0006-2960
DOI: 10.1021/bi400664k

App C., Knop J., Mannherz HG., Hannappel E.:
Identification of interaction partners of ?-thymosins: application of thymosin ?4 labeled by transglutaminase
In: Annals of the New York Academy of Sciences 1270 (2012), p. 98-104
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2012.06658.x
Goldstein AL., Hannappel E., Sosne G., Kleinman HK.:
Thymosin ?4: a multi-functional regenerative peptide. Basic properties and clinical applications
In: Expert Opinion on Biological Therapy 12 (2012), p. 37-51
ISSN: 1471-2598
DOI: 10.1517/14712598.2012.634793

2008

Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, M¸ller S, Willhauck M, Spitzweg C, Gildehaus FJ, M¸nzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.
Circulation. 2008;117(17): 2232-40

Mannherz HG, Dansranjavin T, Gremm D, Mazur A, Sokoll A, Hannappel E, Jockusch B
Thymosin beta 4 inhibits ADF/cofilin stimulated F-actin cycling and cell migration: reversal by the FH2-domain of mDia1
Eur J Cell Biol. 2008;87 Suppl. : 23-23

2007

Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M
Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells.
Ann N Y Acad Sci. 2007;1112: 154-60

Hannappel E
beta-Thymosins.
Ann N Y Acad Sci. 2007;1112: 21-37

Bodendorf S, Born G, Hannappel E
Determination of Thymosin beta4 and Protein in Human Wound Fluid after Abdominal Surgery.
Ann N Y Acad Sci. 2007;1112: 418-24

Zoubek RE, Hannappel E
Influence of the N terminus and the actin-binding motif of thymosin beta4 on its interaction with G-actin.
Ann N Y Acad Sci. 2007;1112: 435-41

Zoubek RE, Hannappel E
Subcellular distribution of thymosin beta4.
Ann N Y Acad Sci. 2007;1112: 442-50

Huff T, M¸ller CS, Hannappel E
Thymosin beta4 is not always the main beta-thymosin in mammalian platelets.
Ann N Y Acad Sci. 2007;1112: 451-7

Villmann C, Sandmeier B, Seeber S, Hannappel E, Pischetsrieder M, Becker CM
Myelin proteolipid protein (PLP) as a marker antigen of central nervous system contaminations for routine food control.
J Agric Food Chem. 2007;55(17): 7114-23

2005

Huff T, Philp D, Gho YS, Hannappel E, Kleinman HK
Beta-thymosins stimulate directional migration of human umbilical vein endothelial cells and promote angiogenesis.
Eur J Cell Biol. 2005;84 Suppl.: 55-55

Goldstein AL, Hannappel E, Kleinman HK
Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues.
Trends Mol Med. 2005;11(9): 421-9

2004

Leeanansaksiri W, DeSimone SK, Huff T, Hannappel E, Huff TF
Thymosin beta4 and its N-terminal tetrapeptide, AcSDKP, inhibit proliferation, and induce dysplastic, non-apoptotic nuclei and degranulation of mast cells.
Chem Biodivers. 2004;1(7): 1091-100

Huff T, Rosorius O, Otto AM, Muller CSG, Hannappel E, Ballweber E, Mannherz HG
Nuclear localization of the G-actin sequestering peptide thymosin beta4
Eur J Cell Biol. 2004;83 Suppl.: 41-41

Huff T, Rosorius O, Otto AM, M¸ller CS, Ballweber E, Hannappel E, Mannherz HG
Nuclear localisation of the G-actin sequestering peptide thymosin beta4.
J Cell Sci. 2004;117(Pt 22): 5333-41

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